Dr Francisco Rivero Crespo

Dr Francisco Rivero Crespo

Reader in Biomedical Science

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Qualifications

  • MBBS (No Partners)
  • PhD / DPhil (Partner to be confirmed)

I contribute to various aspects of the Hull York Medical School MBBS (lectures, biopracticals, scholarship and special interest programme), to the BSc Biomedical Sciences (lectures, projects) and to the MSc in Pharmacology and Drug Development and the MSc Biomedical Sciences.

I'm also the postgreaduate training academic lead of HYMS.

Recent outputs

View more outputs

Journal Article

Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR

Saldanha, P. A., Bolanle, I. O., Palmer, T. M., Nikitenko, L. L., & Rivero, F. (2022). Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR. Cells, 11(15), Article 2315. https://doi.org/10.3390/cells11152315

Bruton's tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia

Naylor-Adamson, L., Chacko, A., Booth, Z., Caserta, S., Jarvis, J., Khan, S., …Arman, M. (2021). Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia. Frontiers in immunology, 12, Article 766272. https://doi.org/10.3389/fimmu.2021.766272

Interactome and evolutionary conservation of dictyostelid small GTPases and their direct regulators

Forbes, G., Schilde, C., Lawal, H., Kin, K., Du, Q., Chen, Z., …Schaap, P. (in press). Interactome and evolutionary conservation of dictyostelid small GTPases and their direct regulators. Small GTPases, https://doi.org/10.1080/21541248.2021.1984829

Inhibition of arginine methylation impairs platelet function

Marsden, A. J., Riley, D. R. J., Barry, A., Khalil, J. S., Guinn, B. A., Kemp, N. T., …Beltran-Alvarez, P. (in press). Inhibition of arginine methylation impairs platelet function. ACS Pharmacology & Translational Science, https://doi.org/10.1021/acsptsci.1c00135

Editorial of Special Issue "Frontiers in the Actin Cytoskeleton"

Rivero, F. (2020). Editorial of Special Issue “Frontiers in the Actin Cytoskeleton”. International Journal of Molecular Sciences, 21(11), Article 3945. https://doi.org/10.3390/ijms21113945

Research interests

Dr Rivero's lab specialises in research into the cytoskeleton, a key player in almost all cellular processes, including motility, cytokinesis, cell-to-cell and cell-susbstrate interactions and intracellular transport. Dr. Rivero is currently pursuing lines of research that explore aspects of the actin cytoskeleton and the signalling pathways that regulate its remodelling in blood platelets. Platelet activation is the result of multiple exquisitely integrated signalling cascades that drive the morphological changes required for adhesion, spreading, aggregation and secretion at the sites of vascular damage. Those signalling pathways ultimately drive remodelling of the platelet cytoskeleton. Platelet physiology is of particular medical relevance because of the role of thrombosis in common cardiovascular conditions such as heart attack and stroke.

The ultimate goals of Dr Rivero's research are a better understanding of platelet function (basic science aspect) and the development of improved diagnostic/therapeutical strategies for the management of states of platelet hyperactivation and other conditions involving platelet/endothelial cell function (translational aspect).

Lead investigator

Project

Funder

Grant

Started

Status

Project

TARGETING THE MYOSIN LIGHT CHAIN PHOSPHATASE WITH PEPTIDE DISRUPTORS: A NOVEL ANTIPLATELET THERAPEUTIC APPROACH

Funder

British Heart Foundation

Grant

£110,680.00

Started

3 July 2023

Status

Ongoing

Project

Coronin is a negative regulator of platelet spreading and thrombus formation

Funder

British Heart Foundation

Grant

£106,915.00

Started

1 July 2016

Status

Complete

Postgraduate supervision

Platelet Biology, Cell Signalling, Cytoskeleton

Journal editorial role

Section editor-in-chief for Cells

2020

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