Dr Barbara Guinn

Dr Barbara Guinn

Reader in Biomedical Sciences

Faculty and Department

  • Faculty of Health Sciences
  • Department of Biomedical Sciences

Qualifications

  • BSc (Aberystwyth University)
  • PhD (Cardiff University)
  • PGCert (University of Hull)

Summary

I am a Reader in Biomedical Sciences at the University of Hull. I have a BSc Genetics from University of Aberyswyth (1991) and a PhD from the University of Wales College of Medicine Cardiff (1995). I then worked at the University of Toronto as a postdoctoral fellow and started my own research group at King's College London in 1999.

I am interested in identifying antigens as targets for immunotherapy (where the immune system is stimulated to kill diseased cells) but we have also realised that disease-specific proteins can provide insights into the biology of disease and biomarkers for disease stage and survival.

Currently we are looking for antigenic targets for the targeted therapy of adult B-cell acute lymphocytic leukaemia, colon and ovarian cancer, as well as endometriosis and incidental lung nodules. We have shown that antigens can act as biomarkers for disease (diagnosis, survival and subtype) as well as providing new insights into the biology underlying these difficult to treat diseases.

Undergraduate

Undergraduate - BSc Programmes

- Molecular and Cell Biology (L5)

- Professional and Research Skills for Biomedical Sciences (L5)

- Human Genetics (L6)

- Clinical Biochemistry (L6)

- Aging, Obesity and Health (L6)

- Final Year Independent Projects (L6)

Postgraduate - MSc Programmes

- Cell & Molecular Biology of Cancer

- Current Topics in Biomedical Sciences

- Research Projects and Dissertation for MSc Biomedical Sciences and MBiochem students

Recent outputs

View more outputs

Journal Article

Antigenic targets for the immunotherapy of acute myeloid leukaemia

Khan, G., Orchard, K., & Guinn, B. (2019). Antigenic targets for the immunotherapy of acute myeloid leukaemia. Journal of Clinical Medicine, 8(2), 134. https://doi.org/10.3390/jcm8020134

Urine biomarkers for the early detection of ovarian cancer – are we there yet"

Grayson, K., Gregory, E., Khan, G., & Guinn, B. (2019). Urine biomarkers for the early detection of ovarian cancer – are we there yet?. Biomarkers in Cancer, 11, https://doi.org/10.1177/1179299x19830977

Sero-profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia

Guinn, B., Jordaens, S., Cooksey, L., Coutinho, M., Van Tendeloo, V., Mills, K., & Orchard, K. (in press). Sero-profiling identifies ibrutinib as a treatment option for young adults with B-cell acute lymphoblastic leukaemia. British journal of haematology,

Retrospective Medical Record Research: Reflections of A Unsponsored Researcher

Bature, F., Guinn, B., Vseteckova, J., Pang, D., & Pappas, Y. (2019). Retrospective Medical Record Research: Reflections of A Unsponsored Researcher. Biomedical Journal of Scientific & Technical Research, 21(4), 16080-16086. https://doi.org/10.26717/BJSTR.2019.21.003642

New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia

Jordaens, S., Cooksey, L., Freire Boullosa, L., Van Tendeloo, V., Smits, E., Mills, K. I., …Guinn, B. (in press). New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia. Cancer Immunology, Immunotherapy, https://doi.org/10.1007/s00262-020-02484-0

Research interests

My research interests focus around antigen identification reflecting my own background in genetics, immunology and cancer research. We use a range of techniques to identify and characterise antigens including SEREX, proto-arrays, cDNA expression arrays, qPCR and pMHC arrays.

I am particularly interested in identifying new biomarkers for difficult to diagnose diseases such as endometriosis, ovarian cancer and lung nodules that develop into cancer. These are often difficult to treat diseases because of their late diagnosis.

Project

Funder

Grant

Started

Status

Project

Impact of CO2 on antigen expression: new ways to induce immune responses against cancer?’

Funder

FRAME

Grant

£1,950.00

Started

1 July 2019

Status

Complete

Postgraduate supervision

Dr Guinn welcomes applications from students who want to study postgraduate research degrees (MSc by Research and PhD). My group is particularly interested in difficult to diagnose and/or treat diseases. To date this has included acute leukaemias, colon, ovarian and lung cancer, and endometriosis, and has led to the identification of biomarkers for survival, target for therapies and improved our understanding of the biological basis of disease.

For more information about possible PhD projects please contact b.guinn@hull.ac.uk

Current PhD students

Eithar Mohamed 2020 - Present. First supervisor.

Janos Kovacs 2019-Present. Second supervisor

Leah Cooksey 2018-Present. First supervisor.

Kelly Grayson 2017- Present. First supervisor.

Completed PhD students

- Holly Wilkinson (2019) Exploring the role of metals and senescence in cutaneous wound healing. University of Hull. Second supervisor.

- Sarah Edge (2019) Investigating the role of miRNA-187 and the downstream PI3K signalling pathway in modulating radiation sensitivity in oesophageal adenocarcinoma. University of Hull. Second supervisor.

- Fidelia Bature (2018) Patterns of signs and symptoms preceding Alzheimer’s Disease diagnosis: A cross sectional study. University of Bedfordshire. Second supervisor.

- Ghazala Khan (2016) Characterisation of the expression of biomarkers and tumour antigens in ovarian cancer and myeloid leukaemia. University of Bedfordshire. First supervisor.

- Emma Buick (2016) The loss of PI3K C2a is associated with a heightened immune response. University of Bedfordshire. Second supervisor.

- Nicola Hardwick (2008) Pre-clinical evaluation of immunotherapy for acute myeloid leukaemia with PASD1 peptide vaccination and autologous whole cell vaccines. King's College London. First supervisor.

- Adam T.C. Cheuk (2005) Immunogene therapy of murine and human acute myeloid leukaemia using costimulatory molecules: A comparison of the efficacy of B7-1, B7-2 and 4-1BBL. King's College London. First supervisor.

Current MSc by Research Students

Jodie Manton, First supervisor.

Sara Goodman, First supervisor.

Daiga Spore, Second supervisor.

Completed MSc by Research Students

- Chloe Warren (2020) Investigating the role of CBX2 in models of triple negative breast cancer. University of Hull. Second supervisor.

- Stephanie Jordaens (2019) Analysis of the expression of antigens in adult B-cell acute lymphocytic leukaemia. University of Hull and University of Antwerp. First supervisor.

- Leah Cooksey (2018) Identification of novel tumour antigens for the immunotherapy of B-cell acute lymphocytic leukaemia. University of Hull. First supervisor.

- Laurie Freire Boullosa (2017) Characterisation of the expression of novel antigens in adult B-acute lymphocytic leukaemia. University of Hull. First supervisor.

- Viktoriya Boncheva, MPhil (2015) The identification of tumour antigens recognised by patients with Dukes’ B reactive colorectal cancers. University of Bedfordshire. First supervisor.

- Hans Vergauwen (2011) Optimisation of the pMHC array for the identification of leukaemia-associated antigen-specific T cells in leukaemia patients. University of Southampton & University of Antwerp. First supervisor.

- Frances Denniss (2006) The protein expression of two leukaemia associated antigens in AML: PASD1 and SSX2IP and the potential as targets for immunotherapy. King’s College London. First supervisor.

Charity role

Cancer Research U.K. Ambassador

2007

External examiner role

External Examiner to BSc Biomedical Sciences at Newcastle

2017

External Assessor for BSc Biomedical Sciences - Aberystwyth University

2019 - 2019

Journal editorial role

Editor-in-Chief Biomarkers in Cancer

2008 - 2019

Associate Editor, Journal of Translational Medicine

2000

Associate Editor for the ‘Translational Hematology’ section of Journal of Translational Medicine. Role includes assessing manuscripts in the field of Translational Hematology, guiding them through the peer review process and ensuring they adhere to the ethos, editorial standards, policies and scope of the journal. Associate Editors’ are encouraged to take an active interest in journal development and advocacy.

Membership/Fellowship of professional body

Fellow of the Royal Society of Biology (FRSB)

2014

Genetics Society

1990