My research interests focus around antigen identification reflecting my own background in genetics, immunology and cancer research. We use a range of techniques to identify and characterise antigens including SEREX, proto-arrays, gene expression arrays, RNA-seq, qPCR and pMHC arrays.
I am particularly interested in identifying new biomarkers for difficult to diagnose diseases such as endometriosis, ovarian cancer and lung nodules that develop into cancer. These are often difficult to treat diseases because of their late diagnosis.
Dr Guinn welcomes applications from students who want to study postgraduate research degrees (MSc by Research, MD and PhD). My group is particularly interested in difficult to diagnose and/or treat diseases. Currently this includes acute leukaemias, ovarian and lung cancer, and endometriosis, and has led to the identification of biomarkers for survival, target for therapies and improved our understanding of the biological basis of disease.
For more information about possible PhD projects please contact firstname.lastname@example.org
Current MD/PhD students
Hannah Draper 2022 - Present.
Eithar Mohamed 2020 - Present.
Leah Cooksey 2018 - Present.
Kelly Grayson 2017 - Present.
Completed MD/PhD students
- Holly Wilkinson (2019) Exploring the role of metals and senescence in cutaneous wound healing. University of Hull.
- Sarah Edge (2019) Investigating the role of miRNA-187 and the downstream PI3K signalling pathway in modulating radiation sensitivity in oesophageal adenocarcinoma. University of Hull.
- Fidelia Bature (2017) Patterns of signs and symptoms preceding Alzheimer’s Disease diagnosis: A cross sectional study. University of Bedfordshire.
- Ghazala Khan (2016) Characterisation of the expression of biomarkers and tumour antigens in ovarian cancer and myeloid leukaemia. University of Bedfordshire.
- Emma Buick (2016) The loss of PI3K C2a is associated with a heightened immune response. University of Bedfordshire.
- Nicola Hardwick (2008) Pre-clinical evaluation of immunotherapy for acute myeloid leukaemia with PASD1 peptide vaccination and autologous whole cell vaccines. King's College London.
- Adam T.C. Cheuk (2005) Immunogene therapy of murine and human acute myeloid leukaemia using costimulatory molecules: A comparison of the efficacy of B7-1, B7-2 and 4-1BBL. King's College London.
Current MSc by Research Students
Alice Fearn, First supervisor.
Elliott Brown, First supervisor.
Daiga Spore, Second supervisor.
Completed Masters (MPhil and MSc by Research) Students
- Sara Goodman (2020) Identification of novel tumour antigens in adults with B-cell acute lymphocytic leukaemia. University of Hull.
- Chloe Warren (2019) Investigating the role of CBX2 in models of triple negative breast cancer. University of Hull.
- Stephanie Jordaens (2019) Analysis of the expression of antigens in adult B-cell acute lymphocytic leukaemia. Erasmus + between University of Hull and University of Antwerp.
- Leah Cooksey (2018) Identification of novel tumour antigens for the immunotherapy of B-cell acute lymphocytic leukaemia. University of Hull.
- Laurie Freire Boullosa (2017) Characterisation of the expression of novel antigens in adult B-acute lymphocytic leukaemia. Erasmus + between University of Hull and University of Antwerp.
- Viktoriya Boncheva, MPhil (2014) The identification of tumour antigens recognised by patients with Dukes’ B reactive colorectal cancers. University of Bedfordshire.
- Hans Vergauwen (2011) Optimisation of the pMHC array for the identification of leukaemia-associated antigen-specific T cells in leukaemia patients. Erasmus + between University of Southampton & University of Antwerp.
- Frances Denniss (2006) The protein expression of two leukaemia associated antigens in AML: PASD1 and SSX2IP and the potential as targets for immunotherapy. King’s College London.