My research interests focus around antigen identification reflecting my own background in genetics, immunology and cancer research. We use a range of techniques to identify and characterise antigens including SEREX, proto-arrays, cDNA expression arrays, qPCR and pMHC arrays.
I am particularly interested in identifying new biomarkers for difficult to diagnose diseases such as endometriosis, ovarian cancer and lung nodules that develop into cancer. These are often difficult to treat diseases because of their late diagnosis.
Dr Guinn welcomes applications from students who want to study postgraduate research degrees (MSc by Research and PhD). I am particularly interested in difficult to diagnose and/or treat diseases. To date this has included acute leukaemias, colon, ovarian and lung cancer, and endometriosis, and has led to the identification of biomarkers for survival, target for therapies and improved our understanding of the biological basis of disease.
For more information about possible PhD projects please contact email@example.com
Current PhD students
Eithar Mohamed 2020 - Present. First supervisor.
Janos Kovacs 2019-Present. Second supervisor
Leah Cooksey 2018-Present. First supervisor.
Kelly Grayson 2017- Present. First supervisor.
Completed PhD students
Holly Wilkinson (2019) Exploring the role of metals and senescence in cutaneous wound healing. University of Hull. Second supervisor.
Sarah Edge (2019) Investigating the role of miRNA-187 and the downstream PI3K signalling pathway in modulating radiation sensitivity in oesophageal adenocarcinoma. University of Hull. Second supervisor.
Fidelia Bature (2018) Patterns of signs and symptoms preceding Alzheimer’s Disease diagnosis: A cross sectional study. University of Bedfordshire. Second supervisor.
Ghazala Khan (2016) Characterisation of the expression of biomarkers and tumour antigens in ovarian cancer and myeloid leukaemia. University of Bedfordshire. First supervisor.
Emma Buick (2016) The loss of PI3K C2a is associated with a heightened immune response. University of Bedfordshire. Second supervisor.
Nicola Hardwick (2008) Pre-clinical evaluation of immunotherapy for acute myeloid leukaemia with PASD1 peptide vaccination and autologous whole cell vaccines. King's College London. First supervisor.
Adam T.C. Cheuk (2005) Immunogene therapy of murine and human acute myeloid leukaemia using costimulatory molecules: A comparison of the efficacy of B7-1, B7-2 and 4-1BBL. King's College London. First supervisor.