Dr Dan Hampshire

Dr Dan Hampshire

Lecturer in Genetics

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Qualifications

  • BSc (University of Leeds)
  • PhD / DPhil (University of Leeds)
  • PCAP (University of Hull)

Summary

Post-PhD, I worked within the Haemostasis Research Group (University of Sheffield) with Prof. Anne Goodeve and Prof. Ian Peake for 12 years funded by a USA National Institutes of Health Program Project Grant (NIH-PPG) in collaboration with colleagues based at the BloodCenter of Wisconsin, Milwaukee WI, USA (Prof. Robert Montgomery) and Queen’s University, Kingston ON, Canada (Prof. David Lillicrap). My initial research associated with this NIH-PPG as a postdoctoral researcher revealed a range of genetic mechanisms involved in the pathogenesis of the bleeding disorder von Willebrand disease that result in quantitative deficiency or functional defects of the plasma glycoprotein von Willebrand factor (VWF). My role in this NIH-PPG subsequently developed into a Senior Scientist as I began to design and supervise (in addition to conduct) my own research focused specifically on identifying genetic factors that may contribute to the unusually wide variation in VWF plasma levels observed in the general population.

As part of the BSc in Biomedical Science degree programme, I currently teach on the following modules: Blood Sciences (level 5), Clinical Haematology (level 6) and Human Genetics (level 6). I also deliver material for MBBS Phase I and teach on the MSc in Biomedical Sciences modules Diseases in Biomedicine and Biomedical Sciences Research Project (module lead). I supervise both undergraduate and taught postgraduate research projects.

Recent outputs

View more outputs

Journal Article

Factor VII deficiency: a cause of (or risk factor for) bleeding?

Hampshire, D. J. (2023). Factor VII deficiency: a cause of (or risk factor for) bleeding?. British journal of haematology, 202(3), 457-458. https://doi.org/10.1111/bjh.18806

Characterization of large in-frame von Willebrand factor deletions highlights differing pathogenic mechanisms

Cartwright, A., Webster, S. J., de Jong, A., Dirven, R. J., Bloomer, L. D. S., Al-Buhairan, A. M., …Hampshire, D. J. (2020). Characterization of large in-frame von Willebrand factor deletions highlights differing pathogenic mechanisms. Blood Advances, 4(13), 2979-2990. https://doi.org/10.1182/bloodadvances.2018027813

The EAHAD blood coagulation factor VII variant database

Kemball-Cook, G., Giansily-Blaizot, M., Giansily‐Blaizot, M., Rallapalli, P. M., Perkins, S. J., Kemball‐Cook, G., …McVey, J. H. (2020). The EAHAD blood coagulation factor VII variant database. Human Mutation, 41(7), 1209-1219. https://doi.org/10.1002/humu.24025

The European Association for Haemophilia and Allied Disorders (EAHAD) Coagulation Factor Variant Databases: Important resources for haemostasis clinicians and researchers

McVey, J. H., Rallapalli, P. M., Kemball‐Cook, G., Hampshire, D. J., Giansily‐Blaizot, M., Gomez, K., …Ludlam, C. A. (2020). The European Association for Haemophilia and Allied Disorders (EAHAD) Coagulation Factor Variant Databases: Important resources for haemostasis clinicians and researchers. Haemophilia, 26(2), 306-313. https://doi.org/10.1111/hae.13947

A bioinformatics toolkit: in silico tools and online resources for investigating genetic variation

Webster, S. J., Aldossary, M. A., & Hampshire, D. J. (2019). A bioinformatics toolkit: in silico tools and online resources for investigating genetic variation. Seminars in Thrombosis and Hemostasis, 45(7), 674-684. https://doi.org/10.1055/s-0039-1692978

Research interests

My research focuses specifically on identifying genetic factors that may contribute to the unusually wide variation in von Willebrand factor (VWF) plasma levels observed in the general population. An increased understanding of the factors influencing VWF levels has important implications given that variation in VWF levels is associated with susceptibility to both bleeding (reduced VWF levels) and thrombosis (elevated levels). My research in this area has investigated the transcriptional regulation of the VWF gene and other genetic modifiers of VWF level including single nucleotide variants within the VWF locus previously thought to be ‘neutral’ common polymorphisms. Applying the knowledge and experience I have gained to date, I now aim to ascertain the role that natural variation in plasma VWF levels has in determining clinical outcomes following treatment in patients with acute coronary syndromes.

Lead investigator

Project

Funder

Grant

Started

Status

Project

Understanding the association of von Willebrand factor genetic variation and levels with cardiovascular disease outcomes

Funder

Academy of Medical Sciences

Grant

£99,999.00

Started

1 August 2023

Status

Ongoing

Postgraduate supervision

Enquiries from prospective students interested in undertaking a postgraduate research degree (MSc by Thesis or PhD) are welcome.

Awards and prizes

International Society on Thrombosis and Haemostasis Young Investigator Award

2011

International Society on Thrombosis and Haemostasis Young Investigator Award

2009

Committee/Steering group role

Committee Member: Human Genome Organisation Gene / Disease Specific Database Advisory Council

2021

Co-chair: ClinGen von Willebrand Disease Variant Curation Expert Panel

2019

Committee Member: ClinGen Hemostasis/Thrombosis Clinical Domain Working Group

2019

Committee Member: Human Variome Project Gene / Disease Specific Database Advisory Council

2011 - 2019

Member: European Association for Haemophilia and Allied Disorders Coagulation Factor Variant Databases Steering Group

2011

Honorary position

Honorary Research Fellow, University of Sheffield

2018 - 2020

Journal editorial role

Blood Coagulation and Fibrinolysis

2020

Membership/Fellowship of professional body

Advance HE Fellow (FHEA)

2021

National/International learned society/body role

Committee Member: British Society for Haemostasis and Thrombosis

2023

Co-chair: International Society of Thrombosis and Haemostasis Scientific and Standardization Committee on von Willebrand factor

2012 - 2015

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