Dr David Allsup

Dr David Allsup

Senior Lecturer in Haematology and Honorary Consultant

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Qualifications

  • BSc (University of Leicester)
  • PhD (University of Liverpool)
  • BSc (University of Leicester)

Summary

Dr David Allsup is a Senior Lecturer in Haematology with an Honorary NHS appointment with Hull and East Yorkshire Hospitals NHS Trust, based in the Queens Centre for Oncology and Haematology at Castle Hill Hospital. He is the local haemophilia director and has additional clinical interests in inherited and acquired platelet disorders. He is also the local lead for chronic lymphocytic leukaemia (CLL), in which he has a longstanding research interest.

Dr Allsup is a member of the BRIDGE-BPD consortium investigating the aetiology of rare disorders of haemostasis and also an active member of the NCRI CLL clinical trials subgroup as well as being a co-investigator on the phase III clinical trial FLAIR.

Undergraduate

Dr Allsup is a keen educator and supporter of the generation of scientists and clinicians. His teaching roles include:-

Academic lead for the Hull York Medical School Phase II Scholarship and Special Interests Programme.

Undergraduate medical student teaching in phase II.

Haematology postgraduate teaching.

Module lead for Hull York Medical School MSc "Pharmacology and Drug Development."

Educational and clinical supervisor to medical and haeamtology trainees.

Recent outputs

View more outputs

Journal Article

Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology

Went, M., Sud, A., Speedy, H., Sunter, N. J., Försti, A., Law, P. J., …Houlston, R. S. (2019). Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology. Blood Cancer Journal, 9(1), https://doi.org/10.1038/s41408-018-0162-8

Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood

Das, A. A., Medlock, J., Liang, H., Nees, D., Allsup, D. J., Madden, L. A., & Paunov, V. N. (2019). Bioimprint aided cell recognition and depletion of human leukemic HL60 cells from peripheral blood. Journal of materials chemistry B, Materials for biology and medicine /, 7(22), 3497-3504. https://doi.org/10.1039/c9tb00679f

Next-generation sequencing for the diagnosis of MYH9-RD

Bury, L., Megy, K., Stephens, J. C., Grassi, L., Greene, D., Gleadall, N., …Simeoni, I. (in press). Next-generation sequencing for the diagnosis of MYH9-RD. Human Mutation, https://doi.org/10.1002/humu.23927

Targeted removal of blood cancer cells from mixed cell populations by cell recognition with matching particle imprints

Remaud, P., Medlock, J., Das, A. A. K., Allsup, D. J., Madden, L. A., Nees, D., …Paunov, V. N. (2019). Targeted removal of blood cancer cells from mixed cell populations by cell recognition with matching particle imprints. Materials Chemistry Frontiers, 4(1), 197-205. https://doi.org/10.1039/c9qm00531e

Removal of Human Leukemic Cells from Peripheral Blood Mononuclear Cells by Cell Recognition Chromatography with Size Matched Particle Imprints

Chester, R., Das, A. A. K., Medlock, J., Nees, D., Allsup, D. J., Madden, L. A., & Paunov, V. N. (2020). Removal of Human Leukemic Cells from Peripheral Blood Mononuclear Cells by Cell Recognition Chromatography with Size Matched Particle Imprints. ACS Applied Bio Materials, 3(2), 789-800. https://doi.org/10.1021/acsabm.9b00770

Research interests

His research interests include:-

Platelet disorders.

The biology of chronic lymphocytic leukaemia.

Novel therapeutic approaches for haematological malignancies.

Clinical trials.

Patient pathways.

Postgraduate supervision

Inherited and acquired platelet disorders.

Chronic lymphocytic leukaemia.

Novel treatments for leukaemia.

Clinical trials.

Patient experience of cancer.

Clinical role

Honorary Consultant

2018 - 2019

Honorary Consultant

Committee/Steering group role

NCRI CLL clinical studies subgroup member

2010 - 2019

NCRI CLL clinical studies subgroup member

Member of Trial Management Group FLAIR clinical trial

2013 - 2021

Member of Trial Management Group FLAIR clinical trial

Member of Trial Management Group for LIPS

2018 - 2019

Co-investigator, and member of trial management group, of a registry study of acute leukaemia and pregnancy.

Conference presentation

Multicenter Genome Wide Association Study Identifies Constitutional Risk Alleles for Progressive Chronic Lymphocytic Leukemia

2019 - 2019

David Allsup, Wei-Yu Lin, Sarah Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Timothy Barrow, Tryfonia Mainou-Fowler, Rachel Piddock, Helen Marr, Jonathan Wallis, Scott Marshall, Andrew Pettitt, Christopher Pepper, Christopher Fegan, Francesco Forconi, Martin JS Dyer, Sandrine Jayne, April Sellors, Anna Schuh, Pauline Robbe David Oscier, Richard S. Houlston, James Bailey, Syed Rais, Alison Bentley, Lynn Cawkwell, Peter Hillmen, Guy Pratt , James Allan. Conference presentation, American Society for Haematology, Orlando, December 2019.

Splenectomy in immune thrombocytopenia: do changing treatment patterns for ITP affect outcome? Data from the UK ITP registry

2020 - 2020

Co-author on above presentation at BSH 2020

Btk inhibitors Ibrutinib and Acalabrutinib impair Fc?RIIA-mediated responses of healthy donor platelets and Chronic Lymphocytic Leukaemia platelets to bacteria.

2020 - 2020

Co-author on above poster presentation at BSH 2020.

External examiner role

External Phd examiner.

2004 - 2019

Dr Allsup has acted as external examiner in six PhD vivas.

Membership/Fellowship of professional body

MRCP

1996 - 1996

MRCP

FRCPath

2004 - 2019

Fellow Royal College of Pathologist

BSH

2000 - 2019

Member of British Society for Hematology

UKHCDO

2005 - 2019

Member of United Kingdom Haemophilia Centre Directors Organisation.

Fellow Higher Education Academy

2019