Torch

Professor Steve Archibald

Professor in Molecular Imaging Chemistry

Faculty and Department

  • Faculty of Health Sciences
  • School of Life Sciences

Summary

Research areas in the Archibald group are PET probe development, chemokine receptor imaging and lab-on-a-chip/ microfluidic devices for radiosynthesis and quality control. Prof Archibald was awarded a first class BSc degree in Chemistry, Life Systems and Pharmaceuticals by the University of York in 1992 and a PhD in Chemistry by the University of Edinburgh in 1995. He carried out postdoctoral research at the Universities of Paris-Sud (France), Kansas (USA) and York (UK), before being appointed as a lecturer at the University of Hull in 2000. Prof Archibald was promoted to Senior Lecturer in 2008, Reader in 2011, Director of the Positron Emission Tomography Research Centre in 2013 and Professor in 2014.

Journal Article

Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis

Aliyu, S. A., Avery, G., Cawthorne, C., Archibald, S. J., Kadir, T., Willaime, J. M., …Crooks, M. G. (2018). Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis. The European respiratory journal, 52(5), 1801138. https://doi.org/10.1183/13993003.01138-2018

Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion

Burke, B. P., Grantham, W., Burke, M. J., Nichol, G. S., Roberts, D., Renard, I., …Lusby, P. J. (2018). Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion. Journal of the American Chemical Society, 140(49), 16877-16881. https://doi.org/10.1021/jacs.8b09582

Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles

Cain, A. N., Carder Freeman, T. N., Roewe, K. D., Cockriel, D. L., Hasley, T. R., Maples, R. D., …Hubin, T. J. (2019). Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles. Dalton transactions : an international journal of inorganic chemistry / RSoC, 48(8), 2785-2801. https://doi.org/10.1039/c8dt04728f

Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads

Hubin, T. J., Walker, A. N., Davilla, D. J., Carder Freeman, T. R. N., Epley, B. M., Hasley, T. R., …Khan, M. O. F. (2019). Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads. Polyhedron, 163, 42-53. https://doi.org/10.1016/j.poly.2019.02.027

Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research

Soultanidis, G., Subiel, A., Renard, I., Reinhart, A. M., Green, V. L., Oelfke, U., …Cawthorne, C. J. (2019). Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research. Physics in Medicine and Biology, 64(12), https://doi.org/10.1088/1361-6560/ab215b

Synthesis, structure, and cytotoxicity studies of oxidovanadium(IV and V) complexes bearing chelating phenolates

Miller-Shakesby, D. M., Nigam, S., Brookfield, A., McInnes, E. J., Prior, T. J., Archibald, S. J., & Redshaw, C. (2019). Synthesis, structure, and cytotoxicity studies of oxidovanadium(IV and V) complexes bearing chelating phenolates. Polyhedron, 171, 1-9. https://doi.org/10.1016/j.poly.2019.06.051

Copper-64 PET imaging of the CXCR4 chemokine receptor using a cross-bridged cyclam bis-tetraazamacrocyclic antagonist

Burke, B., Miranda, C., Lee, R., Renard, I., Nigam, S., Clemente, G., …Archibald, S. (2019). Copper-64 PET imaging of the CXCR4 chemokine receptor using a cross-bridged cyclam bis-tetraazamacrocyclic antagonist. The Journal of nuclear medicine : JNM, jnumed.118.218008. https://doi.org/10.2967/jnumed.118.218008

Side-bridged cyclam transition metal complexes bearing a phenolic ether or a phenolate pendent arm

Mewis, R. E., & Archibald, S. J. (2019). Side-bridged cyclam transition metal complexes bearing a phenolic ether or a phenolate pendent arm. Polyhedron, https://doi.org/10.1016/j.poly.2019.08.003

Project

Funder

Grant

Started

Status

Project

Medical Imaging Alliance: Siberia and Hull

Funder

British Council

Grant

£37,600.00

Started

3 September 2018

Status

Ongoing

Postgraduate supervision

Prof Archibald welcomes applications in all aspects of medical imaging science and positron emission tomography, particularly - nuclear imaging (PET and SPECT) - molecular imaging probe development - radiochemistry - use of radiometals - development of receptor protein targeting (small molecules, peptides and antibodies) - targeted radionuclides for therapy - radiopharmacy and translational research Completed PhDs - Cheryll Allan (2005) - Christopher Fisher (2005) - Gary Nicholson (2006) - Jon Silversides (2006) - Amanda Sparke (2008) - Christopher Welch (2009) (2nd Supervisor) - Graeme McRobbie (2009) - Ryan Mewis (2009) - Abid Khan (2010) - Rachel Smith (2013) - Benjamin Burke (2013) - Naomi Jones (2015) (2nd Supervisor) - Kati Nicholson (2015) - Ali Al-Zirgani (2016) - Neazar Baghdadi (2016) - Seraj Omar Al-Zahrani (2016) - Mustafa Al-Yassiry (2016) - Bassim Wahaab (2016) - David Millar (2016) (2nd supervisor) - Shubhanchi Nigam (2017) - Alicja Kownacka (2017) Current PhD supervisions - Zainab Abdallah Al-Ali - Boon-Uma Jowanarhidi - Hayley Bignell - Tahani Alresheedi - Fada Jabber - Rhiannon Lee - Isaline Renard - Rebecca Ullah (2nd supervisor) - James Thompson (2nd supervisor) - Noemi Perujo Holland (2nd supervisor)