Dr Louis Allott

Dr Louis Allott

Lecturer in Translational Radiopharmaceutics

Faculty and Department

  • Faculty of Health Sciences
  • Department of Biomedical Sciences

Summary

Louis graduated from the University of Hull in 2011 with a Master of Chemistry (MChem) degree. He completed his PhD in PET Radiochemistry with Dr Graham Smith and Dr Chris Cawthorne at the University of Hull in 2014 where he developed novel fluorine-18 radioligands for positron emission tomography (PET) imaging of progesterone receptor expression in breast cancer. In 2014, Louis began three years of post-doctoral work in the Division of Radiotherapy and Imaging, Institute of Cancer Research, London with Dr Graham Smith; notable projects included development of radiolabelled Affibody molecules for imaging HER3 expression, new chelators for zirconium-89 radiochemistry and automation of the aluminium-[18F]fluoride radiolabelling method. In 2017 he moved to the Faculty of Medicine, Imperial College London to join the group of Prof Eric O. Aboagye as a Research Associate and Chemistry Team Leader. Louis and the team worked on numerous projects from radiolabelled small molecules to biomolecules, with a drive towards progressing molecules into clinical trials. In 2021, Louis re-joined the University of Hull as Lecturer in Translational Radiopharmaceutics to establish his independent research and help deliver the new Molecular Imaging Research Centre (MIRC) at Castle Hill Hospital. The MIRC a partnership between the University of Hull, the Daisy Appeal and the Hull University Teaching Hospital NHS Trust, and will bring cutting-edge translational PET research to Hull and the surrounding area.

Recent outputs

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Journal Article

The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

Archibald, S., & Allott, L. (2021). The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules. EJNMMI Radiopharmacy and Chemistry, 6, https://doi.org/10.1186/s41181-021-00141-0

Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019

Wang, N., Brickute, D., Braga, M., Barnes, C., Lu, H., Allott, L., & Aboagye, E. O. (2021). Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019. Pharmaceutics, 13(7), https://doi.org/10.3390/pharmaceutics13071078

Detecting hypoxia in vitro using 18F-pretargeted IEDDA "click" chemistry in live cells

Allott, L., Chen, C., Braga, M., Leung, S. F. J., Wang, N., Barnes, C., …Aboagye, E. O. (in press). Detecting hypoxia in vitro using 18F-pretargeted IEDDA “click” chemistry in live cells. RSC advances, 11(33), 20335-20341. https://doi.org/10.1039/d1ra02482e

Radiolabelling an 18F biologic via facile IEDDA "click" chemistry on the GE FASTLab™ platform

Allott, L., Amgheib, A., Barnes, C., Braga, M., Brickute, D., Wang, N., …Aboagye, E. O. (in press). Radiolabelling an 18F biologic via facile IEDDA “click” chemistry on the GE FASTLab™ platform. Reaction Chemistry and Engineering, https://doi.org/10.1039/d1re00117e

Research interests

PET Radiochemistry

Automated Radiochemistry

Radiopharmaceutical Development (small-molecules and biomolecules)

Clinical Translation