Dr Louis Allott

Dr Louis Allott

Lecturer in Translational Radiopharmaceutics

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Summary

Louis graduated from the University of Hull in 2011 with a Master of Chemistry (MChem) degree. He completed his PhD in PET Radiochemistry with Dr Graham Smith and Dr Chris Cawthorne at the University of Hull in 2014 where he developed novel fluorine-18 radioligands for positron emission tomography (PET) imaging of progesterone receptor expression in breast cancer. In 2014, Louis began three years of post-doctoral work in the Division of Radiotherapy and Imaging, Institute of Cancer Research, London with Dr Graham Smith; notable projects included development of radiolabelled Affibody molecules for imaging HER3 expression, new chelators for zirconium-89 radiochemistry and automation of the aluminium-[18F]fluoride radiolabelling method. In 2017 he moved to the Faculty of Medicine, Imperial College London to join the group of Prof Eric O. Aboagye as a Research Associate and Chemistry Team Leader. Louis and the team worked on numerous projects from radiolabelled small molecules to biomolecules, with a drive towards progressing molecules into clinical trials. In 2021, Louis re-joined the University of Hull as Lecturer in Translational Radiopharmaceutics to establish his independent research and help deliver the new Molecular Imaging Research Centre (MIRC) at Castle Hill Hospital. The MIRC a partnership between the University of Hull, the Daisy Appeal and the Hull University Teaching Hospital NHS Trust, and will bring cutting-edge translational PET research to Hull and the surrounding area.

Recent outputs

View more outputs

Journal Article

Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform

Yang, Z., Barnes, C., Domarkas, J., Koch-Paszkowski, J., Wright, J., Amgheib, A., …Allott, L. (2023). Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform. Reaction Chemistry and Engineering, 8(10), 2403-2407. https://doi.org/10.1039/d3re00307h

Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells

Brickute, D., Chen, C., Braga, M., Barnes, C., Wang, N., Allott, L., & Aboagye, E. O. (2022). Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells. RSC advances, 12(40), 26372-26381. https://doi.org/10.1039/d2ra04535d

A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms

Barnes, C., Nair, M., Aboagye, E. O., Archibald, S. J., & Allott, L. (2022). A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms. Reaction Chemistry and Engineering, https://doi.org/10.1039/d2re00219a

A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles

Teh, J., Costa-Braga, M., Allott, L., Barnes, C., Hernandez-Gil, J., Tang, M., …Long, N. J. (2021). A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles. Chemical communications : Chem comm / the Royal Society of Chemistry, https://doi.org/10.1039/d1cc04790f

The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

Archibald, S. J., & Allott, L. (2021). The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules. EJNMMI Radiopharmacy and Chemistry, 6(1), Article 30. https://doi.org/10.1186/s41181-021-00141-0

Research interests

PET Radiochemistry

Automated Radiochemistry

Radiopharmaceutical Development (small-molecules and biomolecules)

Clinical Translation

Co-investigator

Project

Funder

Grant

Started

Status

Project

Targeting ADAM10 as a novel strategy for radiotherapy enhancement in hypoxic colorectal cancer

Funder

Bowel and Cancer Research

Grant

£77,266.00

Started

19 September 2021

Status

Ongoing

Project

Radiopharmacy GMP radiotracer production

Funder

Daisy Appeal

Grant

£39,500.00

Started

1 February 2023

Status

Complete

Project

PreclinHUPET2: Enabling Enhanced Preclinical Nuclear Imaging For The North Of England

Funder

MRC Medical Research Council

Grant

£657,700.00

Started

1 February 2023

Status

Complete

Awards and prizes

Successful Research Bid - Faculty of Health Sciences KE Pump Prime Award

2022

Award of £5000 funds to pump prime research.

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