Summary
Research areas in the Archibald group are PET probe development, chemokine receptor imaging and lab-on-a-chip/ microfluidic devices for radiosynthesis and quality control.
Prof Archibald was awarded a first class BSc degree in Chemistry, Life Systems and Pharmaceuticals by the University of York in 1992 and a PhD in Chemistry by the University of Edinburgh in 1995.
He carried out postdoctoral research at the Universities of Paris-Sud (France), Kansas (USA) and York (UK), before being appointed as a lecturer at the University of Hull in 2000.
Prof Archibald was promoted to Senior Lecturer in 2008, Reader in 2011, Director of the Positron Emission Tomography Research Centre in 2013 and Professor in 2014.
Journal Article
Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform
Yang, Z., Barnes, C., Domarkas, J., Koch-Paszkowski, J., Wright, J., Amgheib, A., Renard, I., Fu, R., Archibald, S., Aboagye, E. O., & Allott, L. (2023). Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform. Reaction Chemistry and Engineering, 8(10), 2403-2407. https://doi.org/10.1039/d3re00307h
Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−
Price, T. W., Renard, I., Prior, T. J., Kubíček, V., Benoit, D. M., Archibald, S. J., Seymour, A. M., Hermann, P., & Stasiuk, G. J. (2022). Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−. Inorganic chemistry, 61(43), 17059–17067. https://doi.org/10.1021/acs.inorgchem.2c01992
Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release
Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., Harris, K., Kruusmägi, M., Walther, T., Booth, J., Boa, A. N., Archibald, S. J., Thompson, C., Atkin, S. L., & Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017
A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms
Barnes, C., Nair, M., Aboagye, E. O., Archibald, S. J., & Allott, L. (2022). A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms. Reaction Chemistry and Engineering, https://doi.org/10.1039/d2re00219a
Lead investigator
Project
Funder
Grant
Started
Status
Project
Novel dual CXCR4/CXCR7 receptor drugs: targeting secondary disease progression and resistance to immunotherapy in breast cancer
Funder
Breast Cancer Now
Grant
£31,500.00
Started
1 August 2019
Status
Complete
Project
Translational Research in the Molecular Imaging Research Centre
Funder
Daisy Appeal
Grant
£45,560.00
Started
1 August 2016
Status
Complete
Project
CXCR7/CXCR4 dual receptor cancer theranostics with copper 64 PET imaging
Funder
MRC Medical Research Council
Grant
£63,995.00
Started
1 July 2020
Status
Complete
Project
New technology to improve capability for clinical radiopharmaceutical production
Funder
MRC Medical Research Council
Grant
£564,548.00
Started
1 January 2019
Status
Complete
Project
Positron Emission Tomography research
Funder
Daisy Appeal
Grant
£59,999.00
Started
1 March 2016
Status
Complete
Project
Training scientists to develop and Image materials for Tissue Engineering and Regenerative Medicine (iTERM)
Funder
EC European Commission
Grant
£235,084.00
Started
1 October 2013
Status
Complete
Project
Development of novel acyclic chelates for gallium-68 and scandium-44 radiometals used in PET
Funder
EPSRC Engineering & Physical Sciences Research Council
Grant
£136,858.00
Started
14 June 2021
Status
Complete
Project
CageTag: Caged Theranostics as a Universal Platform for Nuclear Medicine
Funder
EPSRC Engineering & Physical Sciences Research Council
Grant
£481,520.00
Started
1 April 2022
Status
Complete
Project
Radiopharmacy GMP radiotracer production
Funder
Daisy Appeal
Grant
£39,500.00
Started
1 February 2023
Status
Complete
Project
PreclinHUPET2: Enabling Enhanced Preclinical Nuclear Imaging For The North Of England
Funder
MRC Medical Research Council
Grant
£657,700.00
Started
1 February 2023
Status
Complete
Co-investigator
Project
Funder
Grant
Started
Status
Project
TRANSFORM: Reducing Inequalities in Cancer Outcomes in Yorkshire: Realising our potential for innovation in Diagnosis, Patient Management, Survivorship and Palliative Care Research
Funder
YCR Yorkshire Cancer Research
Grant
£1,806,650.00
Started
1 September 2017
Status
Ongoing
Project
Translational nanoconstructs for targeted tissue accumulation and guided surgery in cancer
Funder
EPSRC Engineering & Physical Sciences Research Council
Grant
£572,613.00
Started
1 May 2023
Status
Ongoing
Project
TARGETING THE MYOSIN LIGHT CHAIN PHOSPHATASE WITH PEPTIDE DISRUPTORS: A NOVEL ANTIPLATELET THERAPEUTIC APPROACH
Funder
British Heart Foundation
Grant
£110,680.00
Started
3 July 2023
Status
Ongoing
Project
Medical Imaging Alliance: Siberia and Hull
Funder
British Council
Grant
£37,600.00
Started
3 September 2018
Status
Complete
Project
HPLC purification of GMP PET radiopharmaceuticals in the Molecular Imaging Research Centre (MIRC)
Funder
Sir James Reckitt Charity
Grant
£50,000.00
Started
1 March 2022
Status
Complete
Postgraduate supervision
Prof Archibald welcomes applications in all aspects of medical imaging science and positron emission tomography, particularly
- nuclear imaging (PET and SPECT)
- molecular imaging probe development
- radiochemistry
- use of radiometals
- development of receptor protein targeting (small molecules, peptides and antibodies)
- targeted radionuclides for therapy
- radiopharmacy and translational research
Completed PhDs
- Cheryll Allan (2005)
- Christopher Fisher (2005)
- Gary Nicholson (2006)
- Jon Silversides (2006)
- Amanda Sparke (2008)
- Christopher Welch (2009) (2nd Supervisor)
- Graeme McRobbie (2009)
- Ryan Mewis (2009)
- Abid Khan (2010)
- Rachel Smith (2013)
- Benjamin Burke (2013)
- Naomi Jones (2015) (2nd Supervisor)
- Kati Nicholson (2015)
- Ali Al-Zirgani (2016)
- Neazar Baghdadi (2016)
- Seraj Omar Al-Zahrani (2016)
- Mustafa Al-Yassiry (2016)
- Bassim Wahaab (2016)
- David Millar (2016) (2nd supervisor)
- Shubhanchi Nigam (2017)
- Alicja Kownacka (2017)
Current PhD supervisions
- Zainab Abdallah Al-Ali
- Boon-Uma Jowanarhidi
- Hayley Bignell
- Tahani Alresheedi
- Fada Jabber
- Rhiannon Lee
- Isaline Renard
- Rebecca Ullah (2nd supervisor)
- James Thompson (2nd supervisor)
- Noemi Perujo Holland (2nd supervisor)