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Dr Laura Sadofsky

Lecturer in Respiratory Medicine/ Academic lead for postgraduate training in HYMS

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Summary

Laura Sadofsky is interested in ion channels and their role in cough and airways inflammation. Her laboratory is currently using human cells and tissue to develop models of the human airways. Using these models, she hopes to better understand the changes which occur in the airways in response to viruses as well as environmental stimuli and pharmaceuticals.

MSc Physician Associate Studies - Pharmacology, Prescribing and Therapeutics MBBS Medicine - Phase 1 plenary lectures BSc/MSc Biomedical Science - Research projects

Recent outputs

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Journal Article

Detection of microplastics in human lung tissue using µFTIR spectroscopy

Jenner, L. C., Rotchell, J. M., Bennett, R. T., Cowen, M., Tentzeris, V., & Sadofsky, L. (2022). Detection of microplastics in human lung tissue using µFTIR spectroscopy. The Science of the total environment, 831, Article 154907. https://doi.org/10.1016/j.scitotenv.2022.154907

Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present

Jenner, L., Sadofsky, L., Danopoulos, E., Chapman, E., White, D., Jenkins, R., & Rotchell, J. M. (2022). Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present. Atmosphere, 13(2), Article 265. https://doi.org/10.3390/atmos13020265

Household indoor microplastics within the Humber region (United Kingdom): quantification and chemical characterisation of particles present

Jenner, L., Sadofsky, L., Danopoulos, E., & Rotchell, J. M. (2021). Household indoor microplastics within the Humber region (United Kingdom): quantification and chemical characterisation of particles present. Atmospheric Environment, 259, https://doi.org/10.1016/j.atmosenv.2021.118512

Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production

Atkinson, S. K., Morice, A. H., & Sadofsky, L. R. (2020). Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production. ERJ Open Research, 6(4), Article 00159-2020. https://doi.org/10.1183/23120541.00159-2020

Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy)

Sadofsky, L. R., Hayman, Y. A., Vance, J., Cervantes, J. L., Fraser, S. D., Wilkinson, H. N., …Morice, A. H. (2019). Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy). Lung, 197(6), 687-698. https://doi.org/10.1007/s00408-019-00288-3

Postgraduate supervision

Ion channels including the thermo-Transient Receptor Potential (TRP) cation channels TRPA1, TRPV1, TRPV4 and TRPM8 (TRP ankyrin-1, vanilloid-1, vanilloid-4 and melastatin-8) and purinergic receptors P2X2 and P2X3 - Biomedical Microfluidics - Precision Cut Lung Slices (PCLS) - Human rhinovirus - Cough and airways inflammation Completed PhDs Knaggs J D, The Modulation of Transient Receptor Potential A1 Channel by Natural and Novel Semi-synthetic Compounds via Non-covalent Modification (2016). Fraser S D, Peripheral Blood Leukocyte Immune Responses in Sarcoidosis (2016) Current PhDs - Samantha Atkinson - Arundhasa Chandrabalan - Rebecca Stinson