Dr Laura Sadofsky Lecturer in Respiratory Medicine/ Academic lead for postgraduate training in HYMS +44 (0)1482 462184 | L.R.Sadofsky@hull.ac.uk Faculty and Department Faculty of Health Sciences Hull York Medical School Related groups Centre for Atherothrombosis and Metabolic Disease Biography Teaching Outputs Research/PhD Summary Laura Sadofsky is interested in ion channels and their role in cough and airways inflammation. Her laboratory is currently using human cells and tissue to develop models of the human airways. Using these models, she hopes to better understand the changes which occur in the airways in response to viruses as well as environmental stimuli and pharmaceuticals. Undergraduate MSc Physician Associate Studies - Pharmacology, Prescribing and Therapeutics MBBS Medicine - Phase 1 plenary lectures BSc/MSc Biomedical Science - Research projects Recent outputs View more outputs Journal Article Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production Atkinson, S. K., Morice, A. H., & Sadofsky, L. R. (2020). Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production. ERJ Open Research, 6(4), https://doi.org/10.1183/23120541.00159-2020 Alyn Morice Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy) Sadofsky, L. R., Hayman, Y. A., Vance, J., Cervantes, J. L., Fraser, S. D., Wilkinson, H. N., …Morice, A. H. (2019). Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy). Lung, 197(6), 687-698. https://doi.org/10.1007/s00408-019-00288-3 Holly Wilkinson Simon Hart Alyn Morice N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites Chandrabalan, A., McPhillie, M. J., Morice, A. H., Boa, A. N., & Sadofsky, L. R. (2019). N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites. European Journal of Medicinal Chemistry, 170, 141-156. https://doi.org/10.1016/j.ejmech.2019.02.074 Alyn Morice Andrew Boa Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria Vance, J., Santos, A., Sadofsky, L., Morice, A., & Cervantes, J. (2019). Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria. Lung, 197(1), 89–94. https://doi.org/10.1007/s00408-018-0181-z Alyn Morice Lipid laden macrophages in respiratory disease Sadofsky, L. R., Hayman, Y. A., Hart, S. P., & Morice, A. H. (2017). Lipid laden macrophages in respiratory disease. Journal of Neurogastroenterology and Motility, 23(3), 477-478. https://doi.org/10.5056/jnm17036 Simon Hart Alyn Morice Postgraduate supervision Ion channels including the thermo-Transient Receptor Potential (TRP) cation channels TRPA1, TRPV1, TRPV4 and TRPM8 (TRP ankyrin-1, vanilloid-1, vanilloid-4 and melastatin-8) and purinergic receptors P2X2 and P2X3 - Biomedical Microfluidics - Precision Cut Lung Slices (PCLS) - Human rhinovirus - Cough and airways inflammation Completed PhDs Knaggs J D, The Modulation of Transient Receptor Potential A1 Channel by Natural and Novel Semi-synthetic Compounds via Non-covalent Modification (2016). Fraser S D, Peripheral Blood Leukocyte Immune Responses in Sarcoidosis (2016) Current PhDs - Samantha Atkinson - Arundhasa Chandrabalan - Rebecca Stinson Similar profiles Professor Tim Palmer Centre for Atherothrombosis and Metabolic Disease Matthew Hardman Centre for Atherothrombosis and Metabolic Disease Dr Holly Wilkinson Centre for Atherothrombosis and Metabolic Disease Roger Sturmey Centre for Atherothrombosis and Metabolic Disease