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Dr Laura Sadofsky

Dr Laura Sadofsky

Senior Lecturer in Respiratory Medicine

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Summary

Laura Sadofsky is interested in ion channels and their role in cough and airways inflammation. Her laboratory is currently using human cells and tissue to develop models of the human airways.

Using these models, she hopes to better understand the changes which occur in the airways in response to viruses as well as environmental stimuli, pollutants and pharmaceuticals.

MBBS Medicine

- Phase 1 plenary lectures

- Pharmacology workshops

- Phase 1 and phase 2 SSIPs

BSc/MSc Biomedical Science

- Research projects

Non-medical prescribing

MSc Pharmacology and Drug Development

MSc Pharmacology and Education (programme director)

MSc Physician Associate Studies

Health Professions Education

Recent outputs

View more outputs

Journal Article

Microplastics in the surgical environment

Field, D. T., Green, J. L., Bennett, R., Jenner, L. C., Sadofsky, L., Chapman, E., …Rotchell, J. M. (2022). Microplastics in the surgical environment. Environment International, Article 107630. https://doi.org/10.1016/j.envint.2022.107630

Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening

Jahanfar, F., Sadofsky, L., Morice, A., & D’Amico, M. (2022). Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening. Membranes, 12(10), Article 954. https://doi.org/10.3390/membranes12100954

ATP, an attractive target for the treatment of refractory chronic cough

Zhang, M., Sykes, D. L., Sadofsky, L. R., & Morice, A. H. (2022). ATP, an attractive target for the treatment of refractory chronic cough. Purinergic Signalling, 18, 289-305. https://doi.org/10.1007/s11302-022-09877-z

Detection of microplastics in human lung tissue using µFTIR spectroscopy

Jenner, L. C., Rotchell, J. M., Bennett, R. T., Cowen, M., Tentzeris, V., & Sadofsky, L. (2022). Detection of microplastics in human lung tissue using µFTIR spectroscopy. The Science of the total environment, 831, Article 154907. https://doi.org/10.1016/j.scitotenv.2022.154907

Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present

Jenner, L., Sadofsky, L., Danopoulos, E., Chapman, E., White, D., Jenkins, R., & Rotchell, J. M. (2022). Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present. Atmosphere, 13(2), Article 265. https://doi.org/10.3390/atmos13020265

Postgraduate supervision

Ion channels including the thermo-Transient Receptor Potential (TRP) cation channels TRPA1, TRPV1, TRPV4 and TRPM8 (TRP ankyrin-1, vanilloid-1, vanilloid-4 and melastatin-8) and purinergic receptors P2X2 and P2X3

- Precision Cut Lung Slices (PCLS)

- Human rhinovirus

- Cough and airways inflammation

- The effect of microplastics on respiratory health

Completed PhDs

Stinson R, The use of Precision Cut Lung Slices and Co-culture Modelling to Investigate the Effect of Human Rhinovirus on Cough and Airway Inflammation (2020)

Atkinson S, The Effect of Human Rhinovirus-16 on Thermo-TRP Channels, Hypotonic Activation and ATP Release (2019)

Chandrabalan A, The Mechanism of TRPA1 Activation (2017)

Knaggs J D, The Modulation of Transient Receptor Potential A1 Channel by Natural and Novel Semi-synthetic Compounds via Non-covalent Modification (2016).

Fraser S D, Peripheral Blood Leukocyte Immune Responses in Sarcoidosis (2016)

Current PhDs

- Basir Ahmad

-Nathan Hayes

-Lauren Jenner

-Ekanayake Ekanayake

- Bwalya Chakulya

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