Dr Mark Wade

I am a Senior Lecturer in Molecular Genetics in the Hull York Medical School Centre for Biomedicine (Hull) l where I lead the Cancer Epigenetics Team.

I was awarded my Ph.D. in 2012 having worked in the lab of Professor James Allan at Newcastle University studying the molecular genetics of radiation-induced breast cancer.

Prior to my current role I was a post-doctoral research associate in the lab of Dr Luke Gaughan from 2012-2017 studying the role of histone demethylase (HDMs) enzymes in breast cancer. In particular the function of the HDMs KDM4B and KDM3A and their role in estrogen receptor signalling.

My current research continues to investigate the role of epigenetic regulatory enzymes in cancer development and progression, particularly in breast cancer and glioblastoma, in an aim to identify novel therapeutic targets. My current interests lie in 'epi-reader' proteins which recognise and interpret histone modifications in order to control gene expression.