Professor Thozhukat Sathyapalan

Professor Thozhukat Sathyapalan

Professor of Diabetes, Endocrinology and Metabolism

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Summary

Sathya obtained his undergraduate degree in Medicine from University of Kerala, India in 1996 and his MD (General Medicine) from JIPMER, India. He subsequently did his clinical training in Diabetes and Endocrinology as a Specialist Registrar in Yorkshire Deanery. Sathya was a Clinical Research Fellow in University of Hull and obtained his MD (Diabetes and Endocrinology) in 2009. He was appointed as Senior Lecturer in Hull York Medical School in October 2009, Reader in 2012 and was made Chair in Academic Endocrinology and Metabolism in 2016.

MBBS, Trivandrum Medical College, India 1990-1996

MD (General Medicine), JIPMER, India 1997-2000

Postgraduate Clinical Training (Grampian University Hospitals and Yorkshire Deanery) 2001-2009

Clinical Research Fellow, University of Hull 2006-2008

Senior Lecturer, Hull York Medical School 2009-2012

Reader, Academic Diabetes, Endocrinology and Metabolism 2013-2016

Chair, Academic Diabetes, Endocrinology and Metabolism 2016 -

Postgraduate (clinical)

Organise and lead the Continuing Medical Education programme for endocrine trainees and Consultants in Diabetes and Endocrinology for Health Education Yorkshire and the Humber. RCP-accredited. Delivered by national and international speakers.

Educational and Clinical Supervisor for Foundation year trainees, Core Medical trainees and Specialty Trainees in Endocrinology and diabetes

Undergraduate

Delivering plenary lectures for Hull York Medical School students

Phase II Student Selected Components (SSCs) on ‘patient pathway through research’

Critically appraised topic (CAT) assessment for Phase II students

Thyroid teaching clinics and diabetes teaching clinics for Hull York Medical School Year 4 students

Multi-disciplinary clinical teaching for Year 3 students: type 1 and type 2 diabetes, dedicated sessions with diabetes specialist nurses, podiatrists, and dieticians

OSLER and OSCE examiner for Hull York Medical School Year 4 and 5 medical students

Recent outputs

View more outputs

Journal Article

The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial

Deshmukh, H., Papageorgiou, M., Wells, L., Akbar, S., Strudwick, T., Deshmukh, K., …Sathyapalan, T. (2023). The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial. Nutrients, 15(18), Article 3872. https://doi.org/10.3390/nu15183872

Phytochemicals as substances that affect astrogliosis and their implications for the management of neurodegenerative diseases

Sahebkar, A., Forouzanfar, F., Pourbagher-Shahri, A. M., Vafaee, F., & Sathyapalan, T. (in press). Phytochemicals as substances that affect astrogliosis and their implications for the management of neurodegenerative diseases. Current medicinal chemistry, 30, https://doi.org/10.2174/0929867330666230504121523

An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review

Golpour-Hamedani, S., Pourmasoumi, M., Askari, G., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (in press). An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review. Current medicinal chemistry, 30, https://doi.org/10.2174/0929867330666230413093409

Association between Organochlorine Pesticides and Vitamin D in Female Subjects

Brennan, E., Nandakumar, M., Butler, A. E., Drage, D. S., Sathyapalan, T., & Atkin, S. L. (2023). Association between Organochlorine Pesticides and Vitamin D in Female Subjects. Biomedicines, 11(5), Article 1451. https://doi.org/10.3390/biomedicines11051451

High density lipoprotein-associated proteins in non-obese women with and without polycystic ovary syndrome

Butler, A. E., Moin, A. S. M., Reiner, Ž., Sathyapalan, T., Jamialahmadi, T., Sahebkar, A., & Atkin, S. L. (2023). High density lipoprotein-associated proteins in non-obese women with and without polycystic ovary syndrome. Frontiers in endocrinology, 14, Article 1117761. https://doi.org/10.3389/fendo.2023.1117761

Research interests

His main area of interest is on modulation of cardiometabolic risk through pharmacological and lifestyle interventions in insulin resistant states such as obesity, polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus. He is interested in traditional as well as novel risk factors, specifically endocrine disruptors.

Lead investigator

Project

Funder

Grant

Started

Status

Project

ABCD FSL Audit

Funder

Association of British Clinical Diabetologists (Ltd)

Grant

£30,000.00

Started

1 September 2022

Status

Ongoing

Project

Freeman Fellowship in Diabetes and Endocrinology

Funder

Freeman 1st Foundation

Grant

£350,000.00

Started

1 April 2023

Status

Ongoing

Project

Development and pilot of the “Living with Polycystic Ovary Syndrome (PCOS)” structured education programme

Funder

BDA British Dietetic Association

Grant

£16,090.00

Started

1 April 2019

Status

Complete

Project

Esperion ETC 1002 Study

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£3,977.00

Started

1 November 2016

Status

Complete

Project

PIONEER5: Efficacy and safety of oral semaglutide versus placebo in subjects with type 2 diabetes and moderate renal impairment

Funder

Novo Nordisk

Grant

£27,085.00

Started

1 November 2016

Status

Complete

Project

A Double-blind, Randomized, Parallel-group, Placebo-controlled Study of MLE4901 for the Treatment of Polycystic Ovary Syndrome (PCOS)

Funder

Millendo Therapeutics Inc

Grant

£29,429.00

Started

11 January 2017

Status

Complete

Project

Liberates: Improving glucose control in patients with diabetes following myocardial infarction: The role of a novel glycaemic monitoring strategy

Funder

NIHR National Institute for Health Research

Grant

£11,308.00

Started

1 August 2017

Status

Complete

Project

IVF Study 1: Does Insulin or Endocrine Disruptor levels affect fertility?

Funder

Hull IVF Trust Fund

Grant

£40,000.00

Started

1 January 2014

Status

Complete

Project

IVF Study 2: Does Insulin or Endocrine Disruptor levels affect fertility?

Funder

Hull IVF Trust Fund

Grant

£10,067.00

Started

1 January 2014

Status

Complete

Project

Trial net CRN funding

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£10,117.00

Started

1 January 2016

Status

Complete

Project

The MID (Multi-Modal Intervention Diabetes) - Frail Study

Funder

Fundacion Para La Investigacion Biomedica Del Hospital

Grant

£4,917.00

Started

1 June 2015

Status

Complete

Project

Soy and testosterone: T01057 - Double placebo controlled parallel trial of soy phytoestrogens in patients with compensated hypogonadism

Funder

Food Standards Agency

Grant

£576,336.00

Started

1 October 2009

Status

Complete

Project

TSB Costs (Study 1, 2, 3 & 4): In vitro and in vivo assessment of polyphenol extracts on cardiovascular indices

Funder

BBSRC Biotechnology & Biological Sciences Research Counc

Grant

£163,501.00

Started

1 January 2012

Status

Complete

Project

Sandoz Ltd unfettered donation

Funder

Sandoz UK

Grant

£11,999.00

Started

1 May 2013

Status

Complete

Project

Albiglutide + Insulin Glargine Versus Insulin Lispro + Insulin Glargine in the Treatment of Subjects with Type 2 Diabetes Mellitus: The switch Study

Funder

GlaxoSmithKline UK Limited

Grant

£4,322.00

Started

1 June 2015

Status

Complete

Project

DUAL 8: A 104 week clinical trial comparing long term glycaemic control of insulin degludec/liraglutide (IDegLira) versus insulin glargine therapy in subjects with type 2 diabetes mellitus

Funder

Novo Nordisk UK

Grant

£43,500.00

Started

1 December 2015

Status

Complete

Project

A double-blind, randomized control trial to evaluate the effect of high protein high fibre yogurts on weight loss in overweight and obese women

Funder

General Mills Inc

Grant

£187,096.00

Started

1 June 2015

Status

Complete

Project

Service Users perspectives to accessing Type 2 Diabetes Services within East Riding of Yorkshire

Funder

NHS East Riding of Yorkshire Clinical Commissioning Group

Grant

£20,725.00

Started

1 January 2016

Status

Complete

Project

CRN funding

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£23,238.00

Started

1 September 2021

Status

Complete

Project

CRN funding - HYPER AID

Funder

NIHR National Institute for Health Research

Grant

£6,933.00

Started

1 August 2022

Status

Complete

Project

HHIPP: Hull Hip fracture Intervention and Prevention Programme

Funder

Osprey

Grant

£50,000.00

Started

1 November 2019

Status

Complete

Project

Transition in Type 1 Diabetes: Service Users’ Perspectives on the Transition from Children to Adult Type 1 Diabetes Mellitus Services within Hull and East Riding of Yorkshire

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£18,400.00

Started

1 June 2018

Status

Complete

Postgraduate supervision

Diabetes, Endocrinology and Metabolism

Lifestyle interventions and pharmacological interventions in cardio metabolic conditions

Polycystic ovary syndrome

https://www.hyms.ac.uk/about/news/2023/hull-york-medical-school-launch-freeman-phd-fellowship-in-endocrinology

Completed postdoctoral students (16 students successfully supervised since 2010)

Mohammed Abdalla - Pharmacotherapy of PCOS (Principal Supervisor) (PhD 2022)

Youssra HZ Dakroury - Vitamin D effects in Qatari population (MSc 2022), Weill Cornell at Qatar (Principal Supervisor)

Alexandra Butler - Life, Death and Regenration fo the Beta Cell (Principal Supervisor) (MD 2020)

James England - Parameters for parathyroid surgery in hyperparathyroidism (Principal Supervisor) ( MD - 2018)

Zeeshan Javed – The effect of vitamin D in women with PCOS (PhD 2018) Diabetes and Endocrinology research fund (Principal Supervisor)

Keith Cunningham –The impact of insulin resistance and polycystic ovary syndrome on IVF outcomes. MD (2016) (Principal Supervisor)

Alasdair O Doherty – Effect of exercise of post-prandial hyperlipidaemia. (PhD 2016) (Co-supervisor).

Ahmed Al-Qaissi - The studies on the physiology of insulin action in patients with diabetes mellitus. (MD 2018) (Principal Supervisor)

Ehtesham Ehtesham – Effects of dietary polyphenols on vascular endothelium and cardiovascular health. PhD (2015) (Principal Supervisor).

Anish George – Effect of dysglycaemia on cardiovascular outcome following acute coronary syndrome. MD (2015) (Principal Supervisor).

Constantine Simintiras – The in vitro modelling of the oviduct: Investigating the role of maternal metabolic and endocrine parameters on early embryonic stem cell development – PhD (2014) (Co-supervisor).

Judit Konya –Effect of polyphenols in cardiovascular risk factors. MD (2014) (Principal Supervisor)

Hassan Kahal – (2010-13) The effect of liraglutide on platelet function and atherothormbotic risk in women with polycystic ovary syndrome – PhD (2013) (Principal Supervisor)

Simon Adams – Identification of factors predictive of outcome following bariatric surgery - MD (Surgery) (2011) (Principal supervisor)

Current students

Emmanuel Ssemmondo - Cardiometabolic risk reduction in PCOS (MD)(Principal Supervisor)

Savannah Sygrove - Effect of exercise and lifestyle intervention in PCOS (PhD) (Principal Supervisor) - Freeman Fellowship

Moose Sheikh - (MD) Effect of diabetes on cardiovascular outcomes MD (Principal Supervisor)

Najeeb Shah - (MD) Interventions on metabolic fluctuations on type 2 diabetes (Principal Supervisor)

Sebastian Spencer - (MSc) - Intravenous iron for the treatment of anaemia in peritoneal dialysis patients (Principal Supervisor)

Alexandra Macnamara - (MD) Evaluation of pharmacology teaching for undergraudate medical students (Principal Supervisor)

Haidee Gonzalez - (MD) To evaluate the link between obesity, metabolic syndrome, hyperlipidaemia, NAFLD in inflammatory bowel disease (Principal Supervisor)

Saeed Alqarni - Endoparticle profile in patients with type 2 diabetes (PhD) (Co-supervisor)

Clinical role

Honorary Consultant Endocrinologist

2009

https://www.hull.nhs.uk/research/research-teams/academic-diabetes-endocrinology-and-metabolism-research-team/

Other

External Roles

2009

Administrative roles · Chair of Hull York Medical School Ethics committee (2016 – to date) · Lead the Academic Endocrinology, Diabetes and Metabolism Group at HYMS · Lead the Endocrinology Comprehensive Research Network for Yorkshire and Humber · Member of NIHR CRN national committee for metabolic and endocrine disorders. National Committees · Association of British Clinical Diabetologists (ABCD) National Committee: 2013 – to date · National UK lead for Freestyle Libre audit: 2018 – to date · British Society for Endocrinology, National Clinical Committee: 2014 – 2018; 2020 – to date · UKI NETS Clinical Practice Committee: 2015 – to date · Member of European Neuroendocrine Tumour Society 2017 – to date · Steering Committee for the UK Acromegaly Register: 2016 – 2020 · National Institute of Health Research, Health Technology Assessment, Diagnostic Technologies & Screening Programmes (DTSP) Panel member: 2013-15 · Member of Steering Group – ABCD Nationwide Exenatide/Liraglutide Audit: 2013-18 · Member of Strategic Clinical Network Board (Diabetes), Yorkshire and Humber Group · Member and key stakeholder in the Acne Priority Setting Partnership, James Lind Alliance. · Chairman of Pit Pat, Hull (local branch of Pituitary Foundation, patient support group, UK) Membership of professional bodies · American College of Physicians · British Endocrine Society · American Endocrine Society · Royal College of Physicians (Edinburgh) · Royal College of Physicians (London · Association of British Clinical Diabetologists · European neuroendocrine tumour society · Senior Fellow of Higher Education Academy Editorial board · Scientific Reports (Nature Publishing Group) · Clinical Endocrinology · British Journal of Diabetes (Associate Editor) · Frontiers in Diabetes (Associate Editor) · Therapeutic Advances in Endocrinology and Metabolism External examiner roles · PhD/MD external examiner for University of Warwick; Imperial College, London; University of Cardiff; JIPMER, India; Nottingham Trent University; University of Leicester; Macquarie University, Sidney, Australia · Royal Colleges of Physicians PACES examiner: (2012 – to date) · External examiner for Diploma and MSc courses in Diabetes and Endocrinology, University of South Wales, UK (2013-16) · External examiner for Diabetes MSc, PGDip, PGCert – University of Leicester – distant learning module (2017 – to date ) · External examiner for Diabetes MSc, PGDip, PGCert – University of Leicester – campus module (2019 – to date)

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