Dr Simon Hart Reader in Respiratory Medicine S.Hart@hull.ac.uk Faculty and Department Faculty of Health Sciences Hull York Medical School Related groups Centre for Clinical Sciences Biography Outputs Research/PhD Summary Clinical academic; Research focus on the immunobiology of pulmonary fibrosis and sarcoidosis; Lead clinician for the Hull Interstitial Lung Disease service; PI for ILD clinical trials Recent outputs View more outputs Journal Article Bruton's tyrosine kinase inhibitors impair Fc?RIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia Naylor-Adamson, L., Chacko, A., Booth, Z., Caserta, S., Jarvis, J., Khan, S., …Arman, M. (2021). Bruton’s tyrosine kinase inhibitors impair Fc?RIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia. Frontiers in immunology, 12, Article 766272. https://doi.org/10.3389/fimmu.2021.766272 Francisco Rivero Crespo Stefano Caserta David Allsup A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study protocol Northgraves, M., Cohen, J., Allgar, V., Currow, D., Hart, S., Hird, K., …Hutchinson, A. (2021). A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study protocol. ERJ Open Research, https://doi.org/10.1183/23120541.00955-2020 Matthew Northgraves Miriam Johnson Flavia Swan Ann Hutchinson Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis Fraser, S. D., Crooks, M. G., Kaye, P. M., & Hart, S. P. (2021). Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis. ERJ Open Research, 7(1), https://doi.org/10.1183/23120541.00804-2020 Simon Fraser Michael Crooks Other A Patient's Guide to Pulmonary Fibrosis, Second Edition Jagielka, K., Hockin, E., Faulkner, E. C., Hart, S., & Nikitenko, L. L. (2022). A Patient's Guide to Pulmonary Fibrosis, Second Edition. [print] Leonid Nikitenko Working Paper Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis Faulkner, E. C., Moverley, A. A., Hart, S. P., & Nikitenko, L. L. Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis Leonid Nikitenko Research interests pulmonary fibrosis; sarcoidosis; macrophage biology Project Funder Grant Started Status Project ISABELA1: A Phase 3, randomized, double-blind, parallel-group, placebocontrolled multicenter study to evaluate the efficacy and safety of two doses of GLPG1690 in addition to local standard of care for minimum 52 weeks in subjects with idiopathic pulmonary fibrosis. Funder Hull University Teaching Hospitals NHS Trust Grant £38,885.00 Started 1 August 2019 Status Ongoing Project TR12: A Phase 2, Double-blind, Randomized, Placebo-controlled, Two-Treatment, Two-Period Crossover Efficacy and Safety Study in Idiopathic Pulmonary Fibrosis with Nalbuphine ER Tablets for the Treatment of Cough Funder Hull University Teaching Hospitals NHS Trust Grant £20,357.00 Started 1 October 2019 Status Ongoing Project A single arm, open-label exploratory clinical trial of azithromycin in pulmonary sarcoidosis Funder SarcoidosisUK Grant £59,992.00 Started 1 March 2019 Status Complete Project Development and application of a multi-scale computational model of sarcoidosis to predict therapeutic approaches for non-self-resolving disease Funder Foundation for Sarcoidosis Research Grant £117,415.00 Started 30 June 2017 Status Complete Project Sir Jules Thorn PhD Scholarship Programme 2016 Funder Jules Thorn Charity Grant £83,999.00 Started 1 September 2016 Status Complete Project Characterisation of monocyte CD200R in pulmonary sarcoidosis Funder BLF British Lung Foundation Grant £116,317.00 Started 1 March 2016 Status Complete Project SCENIC: Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Efficacy and Safety Study with Inhaled RVT-1601 for the Treatment of Persistent Cough in Patients with Idiopathic Pulmonary Fibrosis (IPF) Funder Hull University Teaching Hospitals NHS Trust Grant £17,918.00 Started 1 May 2019 Status Complete Project ATLAS: A Randomized Open-Label, Phase 1b Study of the Safety of Pirfenidone Solution for Inhalation (AP01) in Patients with Idiopathic Pulmonary Fibrosis Funder Hull University Teaching Hospitals NHS Trust Grant £5,937.00 Started 1 June 2019 Status Complete Project An exploratory sub-study to protocol GLPG1690-CL-303 to assess lung function in patients with idiopathic pulmonary fibrosis, using hyperpolarized xenon magnetic resonance imaging Funder Hull University Teaching Hospitals NHS Trust Grant £3,228.00 Started 1 November 2019 Status Complete Similar profiles Josh Totty Centre for Clinical Sciences Professor Alyn Morice Centre for Clinical Sciences Joe Cuthbert Centre for Clinical Sciences Professor Michael Lind Centre for Clinical Sciences