Torch

Dr Simon Hart

Reader in Respiratory Medicine

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Summary

Clinical academic; Research focus on the immunobiology of pulmonary fibrosis and sarcoidosis; Lead clinician for the Hull Interstitial Lung Disease service; PI for ILD clinical trials

Recent outputs

View more outputs

Journal Article

Bruton's tyrosine kinase inhibitors impair Fc?RIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia

Naylor-Adamson, L., Chacko, A., Booth, Z., Caserta, S., Jarvis, J., Khan, S., …Arman, M. (2021). Bruton’s tyrosine kinase inhibitors impair Fc?RIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia. Frontiers in immunology, 12, Article 766272. https://doi.org/10.3389/fimmu.2021.766272

A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study protocol

Northgraves, M., Cohen, J., Allgar, V., Currow, D., Hart, S., Hird, K., …Hutchinson, A. (2021). A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study protocol. ERJ Open Research, https://doi.org/10.1183/23120541.00955-2020

Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis

Fraser, S. D., Crooks, M. G., Kaye, P. M., & Hart, S. P. (2021). Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis. ERJ Open Research, 7(1), https://doi.org/10.1183/23120541.00804-2020

Other

A Patient's Guide to Pulmonary Fibrosis, Second Edition

Jagielka, K., Hockin, E., Faulkner, E. C., Hart, S., & Nikitenko, L. L. (2022). A Patient's Guide to Pulmonary Fibrosis, Second Edition. [print]

Working Paper

Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis

Faulkner, E. C., Moverley, A. A., Hart, S. P., & Nikitenko, L. L. Integrated single-cell RNA sequencing analysis reveals alterations of ageing human lung endothelium heterogeneity in idiopathic pulmonary fibrosis

Research interests

pulmonary fibrosis; sarcoidosis; macrophage biology

Project

Funder

Grant

Started

Status

Project

ISABELA1: A Phase 3, randomized, double-blind, parallel-group, placebocontrolled multicenter study to evaluate the efficacy and safety of two doses of GLPG1690 in addition to local standard of care for minimum 52 weeks in subjects with idiopathic pulmonary fibrosis.

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£38,885.00

Started

1 August 2019

Status

Ongoing

Project

TR12: A Phase 2, Double-blind, Randomized, Placebo-controlled, Two-Treatment, Two-Period Crossover Efficacy and Safety Study in Idiopathic Pulmonary Fibrosis with Nalbuphine ER Tablets for the Treatment of Cough

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£20,357.00

Started

1 October 2019

Status

Ongoing

Project

A single arm, open-label exploratory clinical trial of azithromycin in pulmonary sarcoidosis

Funder

SarcoidosisUK

Grant

£59,992.00

Started

1 March 2019

Status

Complete

Project

Development and application of a multi-scale computational model of sarcoidosis to predict therapeutic approaches for non-self-resolving disease

Funder

Foundation for Sarcoidosis Research

Grant

£117,415.00

Started

30 June 2017

Status

Complete

Project

Sir Jules Thorn PhD Scholarship Programme 2016

Funder

Jules Thorn Charity

Grant

£83,999.00

Started

1 September 2016

Status

Complete

Project

Characterisation of monocyte CD200R in pulmonary sarcoidosis

Funder

BLF British Lung Foundation

Grant

£116,317.00

Started

1 March 2016

Status

Complete

Project

SCENIC: Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Efficacy and Safety Study with Inhaled RVT-1601 for the Treatment of Persistent Cough in Patients with Idiopathic Pulmonary Fibrosis (IPF)

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£17,918.00

Started

1 May 2019

Status

Complete

Project

ATLAS: A Randomized Open-Label, Phase 1b Study of the Safety of Pirfenidone Solution for Inhalation (AP01) in Patients with Idiopathic Pulmonary Fibrosis

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£5,937.00

Started

1 June 2019

Status

Complete

Project

An exploratory sub-study to protocol GLPG1690-CL-303 to assess lung function in patients with idiopathic pulmonary fibrosis, using hyperpolarized xenon magnetic resonance imaging

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£3,228.00

Started

1 November 2019

Status

Complete