Professor Alyn Morice Foundation Chair and Professor of Respiratory Medicine A.H.Morice@hull.ac.uk Faculty and Department Faculty of Health Sciences Hull York Medical School Related groups Centre for Clinical Sciences Biography Outputs Research/PhD Summary Professor Morice is Head of Respiratory Medicine at HYMS, based at the University of Hull. He is also an Honorary Consultant Physician at Hull & East Yorkshire Hospitals NHS Trust. Professor Morice specialises in the diagnosis and treatment of cough, and runs the Hull Cough Clinic. He also runs the Hull Respiratory Clinical Trials Unit, specialising in the treatment of asthma and COPD. The Hull Cough Clinic is one of the largest centres within Europe, with an international pattern of referral. Unique investigational strategies provide diagnosis and treatment advances, which are incorporated into national and international guideline documents. Professor Morice has led the European Respiratory Society and British Thoracic Society Taskforces on Cough. Recent outputs View more outputs Journal Article Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS) Cotton, S., Devereux, G., Abbas, H., Briggs, A., Campbell, K., Chaudhuri, R., …Lipworth, B. J. (2022). Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS). Trials, 23(1), Article 307. https://doi.org/10.1186/s13063-022-06226-8 Chronic Cough in Idiopathic Pulmonary Fibrosis: The Same Difference? Morice, A. H. (2022). Chronic Cough in Idiopathic Pulmonary Fibrosis: The Same Difference?. American Journal of Respiratory and Critical Care Medicine, 205(9), 985-986. https://doi.org/10.1164/rccm.202201-0083ED Chronic cough: new insights and future prospects Morice, A., Dicpinigaitis, P., McGarvey, L., & Birring, S. S. (2021). Chronic cough: new insights and future prospects. European Respiratory Review, 30(162), Article 210127. https://doi.org/10.1183/16000617.0127-2021 Objective cough frequency monitoring in real-world practice Lee, J. H., Song, W. J., Millqvist, E., & Morice, A. H. (2021). Objective cough frequency monitoring in real-world practice. ERJ Open Research, 7(4), Article 00545-2021. https://doi.org/10.1183/23120541.00545-2021 The Cough Reflex: The Janus of Respiratory Medicine Sykes, D. L., & Morice, A. H. (2021). The Cough Reflex: The Janus of Respiratory Medicine. Frontiers in Physiology, 12, Article 684080. https://doi.org/10.3389/fphys.2021.684080 Research interests Professor Morice specialises in the diagnosis and treatment of cough, and runs the Hull Cough Clinic. He also runs the Hull Respiratory Clinical Trials Unit, specialising in the treatment of asthma and COPD. The Hull Cough Clinic is one of the largest centres within Europe, with an international pattern of referral. Unique investigational strategies provide diagnosis and treatment advances, which are incorporated into national and international guideline documents. Professor Morice has led the European Respiratory Society and British Thoracic Society Taskforces on Cough. Project Funder Grant Started Status Project Two-part, double-blind, placebo-controlled, randomized, parallel-group study - (Part 1) in healthy male volunteers to assess safety and tolerability of ascending repeated oral doses of BAY 1817080 followed (Part 2), two-way crossover administration with four-step dose titration in patients with refractory chronic cough to assess safety, tolerability and efficacy for proof of concept and dose-finding Funder Bayer Pharma AG Grant £61,101.00 Started 18 July 2018 Status Complete Project AX-8 Clinical Research Collaboration Funder Hull University Teaching Hospitals NHS Trust Grant £21,285.00 Started 1 June 2016 Status Complete Project BICS: A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease Funder NIHR National Institute for Health Research Grant £27,108.00 Started 1 June 2017 Status Complete Project VOLCANO-2: A double-blind, placebo controlled study of the efficacy and safety of three doses of Orvepitant in subjects with chronic refractory cough Funder Hull University Teaching Hospitals NHS Trust Grant £42,493.00 Started 1 August 2017 Status Complete Project Lavolta - A phase III, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of Funder Hull University Teaching Hospitals NHS Trust Grant £19,047.00 Started 18 May 2014 Status Complete Project OSPREY: An Observational Study of the Phenotype and pRescribing in East Yorkshire and its relevance to the introduction of new prescribing guidelines for airways disease. Funder AstraZeneca UK Limited Grant £163,413.00 Started 1 October 2016 Status Complete Project Orbit-4: A multi-centre, randomised, double-blind, placebo-controlled study to evaluate the safety and efficacy of Pulmaquin in the management of chronic lung infections with pseudomonas aeruginosa in subjects with non-cystic fibrosis bronchiectasis, including 28 Funder Aradigm Corporation Grant £30,144.00 Started 31 October 2014 Status Complete Project TUF: The Utility of FeNo in the differential diagnosis of chronic cough Funder Aerocrine AB Grant £30,000.00 Started 2 November 2015 Status Complete Project Development Costs: A Study to Assess the Effect of AF-219 on Cough Reflex Sensitivity in Both Healthy and Chronic Cough Subjects Funder Afferent Pharmaceuticals Inc Grant £62,207.00 Started 5 October 2015 Status Complete Project AFFERENT14: A Study to Assess the Effect of AF-219 on Cough Reflex Sensitivity in Both Healthy and Chronic Cough Subjects Funder Afferent Pharmaceuticals Inc Grant £140,667.00 Started 5 October 2015 Status Complete Project AFFERENT12: AF219-012: A 12 week Study to assess the Efficacy and tolerability of AF 219 in subjects with treatm Funder Afferent Pharmaceuticals Inc Grant £22,020.00 Started 1 March 2016 Status Complete Project Proof of Concept study (POC) to investigate the effect of ambroxol hydrochloride (20mg lozenges) on the cough reflex in patients with acute upper respiratory tract infection Funder Sanofi Aventis Grant £27,342.00 Started 1 October 2017 Status Complete Project RELIEF: A Randomised, Double-blind, Placebo-Controlled, Crossover, Dose Escalation Study of BLU-5937 in subjects with Unexplained or Refractory Chronic Cough Funder Hull University Teaching Hospitals NHS Trust Grant £22,286.00 Started 1 June 2020 Status Complete Project TUSSIX: MTI-110 - A randomized, double-blind, placebo-controlled study of the efficacy, safety, and tolerability of Serlopitant for the treatment of refractory chronic cough Funder Hull University Teaching Hospitals NHS Trust Grant £16,546.00 Started 1 December 2017 Status Complete Project Randomised, double-blind, parallel group. Phase 2b dose-finding, efficacy and safety study of 12-week twice daily oral administration of BAY 1817080 compared to placebo in the treatment of refractory and/or unexplained chronic cough (RUCC) Funder Hull University Teaching Hospitals NHS Trust Grant £26,613.00 Started 1 January 2021 Status Complete Similar profiles Josh Totty Centre for Clinical Sciences Professor Michael Lind Centre for Clinical Sciences Azeem Saleem Centre for Clinical Sciences