I am a Fellow of the Higher Education Academy. I take part in teaching and assessment activities in the Biomedical Science Subject Group at the University of Hull. My teaching interests mostly include Immunology and Cellular and Molecular Biology. I take part in lectures, tutorials and one-to-one teaching activities.
I supervised a number of students in the lab in my past career, including many successful researchers and scientists who are now progressing well in their career. If you are a recent biomedical/biological science / infection and immunity / medicine graduate and would like to join my lab to study any of the above areas, either as a Master or PhD/MD student, please do get in contact: stefano.caserta@hyms.ac.uk
Journal Article
Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia
Tantoush, F., Allsup, D., Naylor-Adamson, L., Voncken, F., & Caserta, S. (2025). Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia. Frontiers in immunology, 16, Article 1531059. https://doi.org/10.3389/fimmu.2025.1531059
Bruton's tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia
Naylor-Adamson, L., Chacko, A., Booth, Z., Caserta, S., Jarvis, J., Khan, S., Hart, S. P., Rivero, F., Allsup, D. J., & Arman, M. (2021). Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia. Frontiers in immunology, 12, Article 766272. https://doi.org/10.3389/fimmu.2021.766272
In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences
Reus, B., Caserta, S., Larsen, M., Morrow, G., Bano, A., Hallensleben, M., Rajkumar, C., Pera, A., & Kern, F. (2021). In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences. Frontiers in immunology, 12, Article 707830. https://doi.org/10.3389/fimmu.2021.707830
Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells
Kirkham, F., Pera, A., Simanek, A. M., Bano, A., Morrow, G., Reus, B., Caserta, S., Smith, H. E., Davies, K. A., Rajkumar, C., & Kern, F. (in press). Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells. Theranostics, 11(12), 5728-5741. https://doi.org/10.7150/thno.58356
Research interests
As an academic, I have research interests in the areas of infection and tumour immunology, inflammation and ageing. My Immunology Lab at Hull York Medical School (University of Hull Campus) is particularly interested on how infection complicates chronic conditions, within a multimorbidity context. On the other hand, we are also interested in understanding how chronic conditions predispose to infection.
For instance, we have active research looking at how pathogens breach/compromise the barrier function of the immune system in patients with diabetic foot ulcers. Other research in my lab is dissecting microbial interactions in cancer (particularly leukemia), with an emphasis on immunological function and tumour-cell behaviour. When pathogens spread beyond the original site of infection (for example, a skin ulcer/wound), they can give rise to a severe systemic illness, known as sepsis. This is a condition currently killing more people than the top three cancers (lung, breast and prostate) combined, in the US/Europe. So additionally, my lab is interested in understanding if specific conditions predispose for sepsis risk; how pathogens involved in sepsis hijack the immune system; and whether this can have an impact even after recovery. Molecular pathways of intercellular communication between immune cells relevant in infection, critical inflammatory conditions and ageing are currently under investigation in any of the above areas.
Co-investigator
Project
Funder
Grant
Started
Status
Project
PD-L1 promotes platelet activation and enhances thrombus formation.
Funder
British Heart Foundation
Grant
£110,207.00
Started
1 October 2022
Status
Ongoing
Project
Using novel endolysins to selectively target antimicrobial resistant S. aureus in chronic wound biofilms
Funder
National Biofilms Innovation Centre
Grant
£114,526.00
Started
1 January 2023
Status
Ongoing
Project
Micreos Contribution to NBIC Studentship
Funder
Micreos Pharma B.V.
Grant
£20,885.00
Started
1 January 2023
Status
Ongoing
Project
Help 4 Health MSc studentships (2nd tranche)
Funder
Humber Teaching NHS Foundation Trust
Grant
£75,000.00
Started
15 February 2025
Status
Ongoing
Project
PreclinHUPET2: Enabling Enhanced Preclinical Nuclear Imaging For The North Of England
Funder
MRC Medical Research Council
Grant
£657,700.00
Started
1 February 2023
Status
Complete
Project
Help 4 Health MSc studentships
Funder
Humber Teaching NHS Foundation Trust
Grant
£72,842.00
Started
1 November 2022
Status
Complete
Postgraduate supervision
Infection and Immunity
T cell biology
Cancer Immunology