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Professor John Greenman

Professor John Greenman

Professor of Tumour Immunology

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Summary

John is a tumour immunologist with extensive experience of developing lab on a chip technology for analysing tumour biopsies.

He has published 180 peer-reviewed publications and his immunobiology group works closely with clinicians, chemists and engineers.

The majority of his research work has focused on tumours of the head and neck region, identifying novel markers of progression or treatment response.

1991-1995 Post-doctoral Research Fellow, Sir William Dunn School of Pathology, MRC Cellular Immunology Unit, University of Oxford

1995-1999 Lecturer in Immunology, Dept of Surgery, University of Hull

1999-2004 Senior Lecturer in Tumour Immunology, University of Hull

2004- 2009 Reader in Tumour Immunology, University of Hull

REF2014 - Appointed as Output Assessor for Panel UoA3 (2014)

REF2020 - UoA3 Panel member

BSc programmes

- Clinical Microbiology and Immunology

- Professional and Research skills for Biomedical Sciences

- Reviews in Biomedical Science

- Final Year Research Projects, 20 and 40 credit

MSc programmes

- Tumour Immunology and Microenvironment

- Organ-specific Cancers: From Bench to Bedside

- Research Project and Dissertation

Recent outputs

View more outputs

Journal Article

Can granulysin provide prognostic value in primary breast cancer?

Milovanovic, J., Todorovic-Rakovic, N., Vujasinovic, T., Greenman, J., Mandušic, V., & Radulovic, M. (2022). Can granulysin provide prognostic value in primary breast cancer?. Pathology - Research and Practice, 237, Article 154039. https://doi.org/10.1016/j.prp.2022.154039

The prognostic significance of serum interferon-gamma (IFN-?) in hormonally dependent breast cancer

Todorovic-Rakovic, N., Milovanovic, J., Greenman, J., & Radulovic, M. (2022). The prognostic significance of serum interferon-gamma (IFN-?) in hormonally dependent breast cancer. Cytokine, 152, Article 155836. https://doi.org/10.1016/j.cyto.2022.155836

Isolation and characterisation of graves' disease-specific extracellular vesicles from tissue maintained on a bespoke microfluidic device

Foster, H., Wade, M., England, J., Greenman, J., & Green, V. (2021). Isolation and characterisation of graves’ disease-specific extracellular vesicles from tissue maintained on a bespoke microfluidic device. Organs-on-a-Chip, 3, Article 100011. https://doi.org/10.1016/j.ooc.2021.100011

Identification of soluble tissue-derived biomarkers from human thyroid tissue explants maintained on a microfluidic device

Riley, A., Jones, H., England, J., Kuvshinov, D., Green, V., & Greenman, J. (2021). Identification of soluble tissue-derived biomarkers from human thyroid tissue explants maintained on a microfluidic device. Oncology Letters, 22(5), Article 780. https://doi.org/10.3892/ol.2021.13041

De-palmitoylation of tissue factor regulates its activity, phosphorylation and cellular functions

Ettelaie, C., Featherby, S., Rondon, A. M. R., Greenman, J., Versteeg, H. H., & Maraveyas, A. (2021). De-palmitoylation of tissue factor regulates its activity, phosphorylation and cellular functions. Cancers, 13(15), Article 3837. https://doi.org/10.3390/cancers13153837

Research interests

Coming from an immunology background, Professor Greenman is extremely interested in understanding how the immune system is often subverted during carcinogenesis, and more importantly how such knowledge can be used clinically (diagnostically, prognostically or therapeutically).

Current and recent grants

H2020-MSCA-RISE-2016, €976,000 (€153k to Hull) (Greenman). Blood test for clinical therapy guidance of non-small cell lung cancer patients.

Yorkshire Cancer Research, €99,198 (Lind and Greenman). Peripheral blood detection of EGFR status in lung cancer patients. 01/11/2016 - 31/10/2018

Innovate UK/EPSRC €496,000 (€193k to Hull) (Greenman, Green, Cawthorne). Development of a multi-purpose small animal phantom for pre-clinical radiotherapy studies. 01/03/2016 - 28/02/2018.

Yorkshire Cancer Research €123,312 (Archibald, Madden & Greenman). Chemokine receptor targeted therapies. 01/02/2014 - 31/01/2016.

British Lung Foundation €24,800 (Loveday, Lind, Haswell & Greenman). Development of microfluidic device for response to chemotherapy in malignant mesothelioma. 01/10/2013 - 30/09/2015.

Technology Strategy Board Sepsis I: Multi-pathogen detection and/or simple discrimination €399,000 (Greenman, Dyer, Haswell, BioGene Ltd). Rapid, on-chip, multiplexed detection of sepsis-causing organisms from blood samples. 01/09/2012 - 31/08/2015.

FP7-SME-2012. Point-of-care blood device for fast and reliable prediction of drug response in non-small cell lung carcinoma patients from blood samples (LungCARD 315586) University of Hull (Haswell & Greenman); Hull and East Riding NHS Trust (Lind & Greenman) (€306,000 to Hull; 1.2M Euro total) 01/01/2013 - 28/2/2014.

NC3R €450,000 (Greenman, Madden, Flynn, Haswell, Maraveyas). Replacement of animal models for tumour biology with a multifunctional microfluidic-based approach. 01/10/2011 - 30/09/2014.

NIHR (i4i programme). €667,542 (Elliott, Wadhawan, Singh, MacFie, Greenman). Development of a placement sensing nasogastric tube. 01/07/2011 - 30/06/2014.

Hull and East Riding Cardiac Trust. €76,128 (Greenman, Jones, Dyer, Wadhawan, Haswell, Griffin, Seymour) Integrated microfluidic devices for real-time measurement of biochemical changes in heart tissue. 01/03/2011 - 30/11/2012.

Heart Research UK €199,728 (Greenman, Haswell and Seymour). Development of microfluidic devices for analysis of function in normal and diseased cardiac tissue. 10/2007 - 09/2011.

EPSRC EP/H007385 €210,949 (Haswell & Greenman). Commercialisation of lab-on-a-chip technology for DNA profiling. 08/2009 - 07/2010.

Project

Funder

Grant

Started

Status

Project

Development of point-of-care and wearable sensors for Hepatitis C diagnostics

Funder

British Council

Grant

£75,000.00

Started

1 September 2020

Status

Ongoing

Project

Investigation of immunological response to chemoradiation, using checkpoint inhibitors, in rectal tumours

Funder

Castle Hill Hospital Cancer Trust Fund

Grant

£75,000.00

Started

1 January 2019

Status

Ongoing

Project

Development of an immune-responsive 3D skin model

Funder

Queen Mary University of London

Grant

£2,900.00

Started

1 May 2019

Status

Complete

Project

Utilising tissue-on-a-chip technology as an ex vivo model of breast cancer metastatic colonisation

Funder

NC3Rs NC3Rs

Grant

£8,771.00

Started

1 July 2019

Status

Complete

Project

Blood test for clinical therapy guidance of non-small cell lung cancer patients

Funder

EC European Commission

Grant

£144,000.00

Started

1 January 2017

Status

Complete

Project

Global analysis of molecular changes in head and neck squamous cell carcinoma (HNSCC) tissue maintained and treated on microfluidic devices

Funder

MRC Medical Research Council

Grant

£44,480.00

Started

1 February 2020

Status

Complete

Project

The effect of corticosteroids on the release of immune modulating factors from Graves’ disease tissue maintained using microfluidic culture.

Funder

British Association of Endocrine & Thyroid Surgeons

Grant

£5,000.00

Started

1 June 2017

Status

Complete

Project

Development of a multipurpose small animal phantom for pre-clinical radiotherapy studies

Funder

Innovate UK

Grant

£193,197.00

Started

1 April 2016

Status

Complete

Project

The Hull-Norwich Gut-Brian Study

Funder

Institute of Food Research

Grant

£33,001.00

Started

31 May 2016

Status

Complete

Project

Lab on a Chip NC3Rs Engagement Award

Funder

NC3Rs NC3Rs

Grant

£1,000.00

Started

15 August 2016

Status

Complete

Project

In vitro analysis of thyroid cancer and it's response to radiotherapy

Funder

Donate for Research Initiative

Grant

£2,500.00

Started

22 May 2015

Status

Complete

Project

Development of an in-vitro model for Parkinson's disease

Funder

University of Essex

Grant

£1,000.00

Started

1 January 2020

Status

Complete

Project

Identification of exosomal miRNA biomarkers in thyroid disease using microfluidics

Funder

ENT UK

Grant

£750.00

Started

1 September 2021

Status

Complete

Project

UKRI Covid 19 Extension Pot - Global analysis of molecular changes in head and neck squamous cell carcinoma (HNSCC) tissue maintained and treated on microfluidic devices

Funder

MRC Medical Research Council

Grant

£13,771.00

Started

1 July 2020

Status

Complete

Project

Understanding cardiac failure in patients with chronic kidney disease

Funder

Hull & East Riding Cardiac Trust Fund

Grant

£19,652.00

Started

1 August 2018

Status

Complete

Postgraduate supervision

I welcome applications to work with me in either the biomedical applications of microfluidic devices or head and neck immunobiology. These can come from basic scientists or medically trained individuals.

Completed PhDs

90 postgraduate (PhD, MD and MSc (Research)) students successfully supervised since 1999.

PhD

Cheah, R. (2016), Monitoring the Response of Head and Neck Tumour Tissue to Irradiation Using a Microfluidic-Based Approach

Smith, J. (2016), The Effect of HNSCC-derived Soluble Factors on the Proliferation and Function of Immune Cells

Chandrabalan, K. (2016), A Microfluidic Approach to the Study of Cellular Responses to Oxidative Stress

Williamson, J. (2016), The Role of Endothelial Adhesins in Leukocyte Adhesion in Response to Pharmaceutical Agents that Induce Pulmonary Fibrosis

Todd, A. (2016), Role of Hypoxia-Induced Adam 10 in Colorectal Cancer Progression

Pacelli, A. (2015), Development of a Pet Probe for the Imaging of Cox-2 Expression in Cancers

MD

Patel, R. (2016), An Observational Pilot Study to Assess the Potential of a Microfluidic Tissue Culture Model to Predict Rectal Cancer Response to Neo-Adjuvant Therapy

Zahoor, T. (2016), Does HPV-16 Seropositivity Correlate with T-cell Distribution Providing Additional Prognostic Information in Infected HNSCC Patients?

Carr, S. (2013), Assessing the Effects of Radiotherapy on Head and Neck Squamous Cell Carcinoma using Microfluidic Techniques

Current PhD supervisors

Currently acting as primary and secondary supervisor to 6 postgraduate students covering all aspects of my research interests.

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