Pedro Beltran Alvarez

Dr Pedro Beltran-Alvarez

Lecturer in Biomedical Sciences

Faculty and Department

  • Faculty of Health Sciences
  • Department of Biomedical Sciences

Qualifications

  • PhD (University of Bristol)

Summary

Pedro did his PhD at the University of Bristol (2004-2007) funded by a Marie Curie grant from the EU. After a short stage in the European Molecular Biology Laboratory (EMBL, Heidelberg, 2007-2009), he joined the Cardiovascular Research Centre at the University of Girona (2009), where he gained a Sara Borrell Postdoctoral Fellowship from the Spanish Government (2011-2014). Pedro then joined the University of Hull in 2015 as a Lecturer in Biomedical Sciences.

Laboratory website: https://sites.google.com/view/beltran-alvarez-lab/home

Undergraduate

Pedro coordinates Biomedical Sciences modules on Biological Basis of Disease (Level 5) and Clinical Biochemistry (Level 6) and additionally teaches on a variety of modules including Biochemistry (L4), Nutrition (L5), Muscle Fitness and Failure (L6), Current Topics in Biomedicine (L7) and Diseases in Biomedicine (L7).

Pedro also contributes to teaching of UG and PG students in modules including Skills for Biomedical Scientists and supervises UG and PG students during their final research projects.

Journal Article

Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity

Sfyri, P. P., Yuldasheva, N. Y., Tzimou, A., Giallourou, N., Crispi, V., Aburima, A., …Matsakas, A. (2018). Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity. Free radical biology & medicine, 129, 504-519. https://doi.org/10.1016/j.freeradbiomed.2018.10.422

Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line

Samuel, S. F., Marsden, A. J., Deepak, S., Rivero, F., Greenman, J., & Beltran-Alvarez, P. (2018). Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line. Proteomes, 6(4), https://doi.org/10.3390/proteomes6040044

The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart

Onwuli, D. O., Samuel, S., Sfyri, P., Welham, K., Goddard, M., Abu-Omar, Y., …Beltran-Alvarez, P. (2019). The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart. International journal of cardiology, 282, 76-80. https://doi.org/10.1016/j.ijcard.2019.01.102

Mapping arginine methylation in the human body and cardiac disease

Onwuli, D. O., Rigau-Roca, L., Cawthorne, C., & Beltran-Alvarez, P. (2017). Mapping arginine methylation in the human body and cardiac disease. Proteomics. Clinical applications, 11(1-2), 1600106. https://doi.org/10.1002/prca.201600106

Do sodium channel proteolytic fragments regulate sodium channel expression"

Onwuli, D. O., Yañez-Bisbe, L., Pinsach-Abuin, M., Tarradas, A., Brugada, R., Greenman, J., …Beltran-Alvarez, P. (2017). Do sodium channel proteolytic fragments regulate sodium channel expression?. Channels, 11(5), 476-481. https://doi.org/10.1080/19336950.2017.1355663

Research interests

Research Mission: to investigate protein post-translational arginine methylation as a biomarker and possible therapeutic target in cardiovascular disease and brain tumours.

Research Vision: to develop ideas and biochemical tools that enable the early diagnosis and targeting of disease.

Currently funded projects: Role of arginine methylation of cardiac troponin I in cardiovascular disease, funded by The Hull and East Riding Cardiac Trust, £29,875. January-December 2019

Postgraduate supervision

Pedro proudly supervises students interested in biochemistry and post-translational modifications, in particular arginine methylation. Current PG students include:

- Sabrina Samuel (2nd year PhD student), who is interested in brain tumours

- Alistair Marsden (1st year PhD student), who is interested in cardiovascular biomarkers

- Lauric Feugere (1st year PhD student second supervisor)

- Srihari Deepak (MD student, second supervisor)

Past supervision: Dr Donatus Onwuli (graduated 2018)

Awards and prizes

Fellow of HEA

2016

Honorary position

Honorary Consultant Endocrinologist

2019