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Professor Matthew Hardman

Chair in Wound Healing / HYMS Director of Research

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Summary

Professor Mat Hardman has more than 20 years' experience in the field of skin biology, with a specific focus on wound healing.

His research, which spans basic biology through to clinical studies, has been funded by the Medical Research Council, National Institutes of Health and a number of charities.

His wound healing group engage with a number of industry partners and the Hull University Teaching Hospitals NHS Trust, ensuring a clear route to patient benefit.

Before moving to Hull, Mat was Director of the EPSRC & MRC Centre for Doctoral Training in Regeneration Medicine at the University of Manchester.

Recent outputs

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Journal Article

Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury

Wilkinson, H. N., Reubinoff, B., Shveiky, D., Hardman, M. J., & Menachem-Zidon, O. B. (2022). Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury. Frontiers in endocrinology, 13, Article 927224. https://doi.org/10.3389/fendo.2022.927224

Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes

Fatima, I., Chen, G., Botchkareva, N. V., Sharov, A. A., Thornton, D., Wilkinson, H. N., …Botchkarev, V. A. (in press). Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes. Journal of Investigative Dermatology, https://doi.org/10.1016/j.jid.2022.04.028

Combined Metallomics/Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair

Wilkinson, H. N., Guinn, B. A., & Hardman, M. J. (2021). Combined Metallomics/Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair. Frontiers in Cell and Developmental Biology, 9, Article 788596. https://doi.org/10.3389/fcell.2021.788596

Human ex vivo wound model and whole-mount staining approach to accurately evaluate skin repair

Wilkinson, H. N., Kidd, A. S., Roberts, E. R., & Hardman, M. J. (2021). Human ex vivo wound model and whole-mount staining approach to accurately evaluate skin repair. Journal of visualized experiments : JoVE, 168, Article e62326. https://doi.org/10.3791/62326

Cellular benefits of single-use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model

Wilkinson, H. N., Longhorne, F. L., Roberts, E. R., Brownhill, V. R., & Hardman, M. J. (in press). Cellular benefits of single-use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model. Wound Repair and Regeneration, https://doi.org/10.1111/wrr.12888

Lead investigator

Project

Funder

Grant

Started

Status

Project

A novel, first-in-its-kind, aptamer-based LYTACs to address the unmet clinical need of diabetic wounds.

Funder

Innovate UK

Grant

£588,893.00

Started

1 December 2022

Status

Ongoing

Project

Development of fully humanised ex vivo human skin wound and infection model

Funder

Animal Free Research UK

Grant

£1,940.00

Started

1 July 2019

Status

Complete

Project

The role of bacteria in the skin: Cold atmospheric plasma for the treatment of pathological skin healing

Funder

British Skin Foundation

Grant

£85,000.00

Started

1 April 2017

Status

Complete

Project

MICA: The role of arginase in chronic delayed wound healing

Funder

MRC Medical Research Council

Grant

£29,842.00

Started

1 August 2016

Status

Complete

Project

Development and application of a new technology for the targeted management of biofilms in human chronic wounds

Funder

Innovate UK

Grant

£29,896.00

Started

1 November 2018

Status

Complete

Co-investigator

Project

Funder

Grant

Started

Status

Project

Re-Purposing Anti-Ageing Drugs to Heal Diabetic Foot Ulcers

Funder

Diabetes UK

Grant

£88,050.00

Started

30 September 2021

Status

Ongoing

Project

Bacterial Modulation of Cellular Senescence in Impaired Skin Healing

Funder

British Skin Foundation

Grant

£85,000.00

Started

1 April 2022

Status

Ongoing

Project

Using novel endolysins to selectively target antimicrobial resistant S. aureus in chronic wound biofilms

Funder

National Biofilms Innovation Centre

Grant

£105,984.00

Started

1 January 2023

Status

Ongoing

Project

A cell model for discovering biomarkers and druggable targets for pulmonary fibrosis

Funder

BLF British Lung Foundation

Grant

£79,958.00

Started

1 May 2023

Status

Ongoing

Project

First-in-man clinical trial investigating the effect of hair cycle modulation on wound healing

Funder

Academy of Medical Sciences

Grant

£30,000.00

Started

1 March 2023

Status

Ongoing

Project

Micreos Contribution to NBIC Studentship

Funder

Micreos Pharma BV

Grant

£20,885.00

Started

1 January 2023

Status

Ongoing

Project

Identification of Fungal Microbiome Signatures in Patients with Blood Cancers Treated in the BioDrive AFS study

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£39,000.00

Started

1 February 2023

Status

Ongoing

Project

HIKE: Generating a Pre-Clinical Data Package to Support Commercialisation and Clinical Translation of Novel Regenerative Scaffolds for Chronic Wounds

Funder

MRC Medical Research Council

Grant

£67,557.00

Started

30 July 2023

Status

Ongoing

Project

Patients and clinicians experiences of hair cycle modulation to facilitate wound healing: a qualitative study within a trial (SWAT)

Funder

BAPRAS

Grant

£19,247.00

Started

1 January 2024

Status

Ongoing

Project

Development of an immune-responsive 3D skin model

Funder

Queen Mary University of London

Grant

£2,900.00

Started

1 May 2019

Status

Complete

Project

Endolysin technology for selective management of MRSA biofilms on skin and wounds

Funder

National Biofilms Innovation Centre

Grant

£38,150.00

Started

1 September 2021

Status

Complete

Project

Depilation Feasibility PPI: The Impact of Depilation upon Wound Healing and Post-Surgical Complications: A Feasibility Study (The DEPILATION-Feasibility STUDY) - Patient and Public Involvement

Funder

NIHR National Institute for Health Research

Grant

£450.00

Started

1 July 2021

Status

Complete

Project

PreclinHUPET2: Enabling Enhanced Preclinical Nuclear Imaging For The North Of England

Funder

MRC Medical Research Council

Grant

£657,700.00

Started

1 February 2023

Status

Complete

Postgraduate supervision

Dr Hardman welcomes applications in microbiology, cell biology, wound healing, stem cells, hair follicles and clinical studies.

Completed PhDs

David Ansell, Hair Cycle and Wound Healing.

Elaine Emmerson, Hormonal Modulation of Wound Healing.

Stuart Mills, Photodynamic Therapy for Wound Repair.

Laura Campbell, Immune-modulation of the Wound Response.

Nichola Cooper, PKCalpha and Cell Adhesion in Wound Healing.

Clare Garcin, EDAR Signaling and Hair Follicles in the Wound Response.

Matt Smith, Estrogen Receptor Polymorphisms in Wound Healing.

Chris Saville, Skin Ageing and Hormone Deficiency: Synergistic Interaction in Wound Healing.

Holly Wilkinson, The Role of Metals in Wound Healing.

Current PhD supervisions

Sammi Iveson, Plasma for the Promotion of Wound Healing, 2017-2020.

Daniel Hardy, The Role of Hair Follicles in Wound Healing, 2017-2020.

Paul Weldrick, Novel Antimicrobials for Wound Healing, 2017-2020.

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