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Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Summary

Dr Shang-Zhong (Sam) Xu is a reader in the Centre for Cardiovascular and Metabolic Research. He obtained his BM in clinical medicine from Shandong Medical University (1986), MSc in Pharmacology from Shanghai Medical University (1989, Shanghai) and MD in Cardiology (1996, Shanghai). He worked as a resident physician, specialist and then associate professor and consultant cardiologist (1989-1998). He was enthusiastic for medical research and moved to Leeds for PhD study (PhD, 2001, Leeds) and then postdoctoral research fellow (2001-2005, Leeds). Sam joined the Postgraduate Medical Institute and Hull York Medical School as a Lecturer in 2005 and became Senior Lecturer, and then Reader in Hull York Medical School. His research focused on ion channels, drug discovery and new target identification for cardiovascular diseases and diabetic complications.

Recent outputs

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Journal Article

Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells

Zaibi, N., Li, P., & Xu, S. (in press). Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells. PLoS ONE, 16(2), Article e0247234. https://doi.org/10.1371/journal.pone.0247234

Evaluating trastuzumab in the treatment of HER2 positive breast cancer

Jaques, R., Xu, S., & Matsakas, A. (2020). Evaluating trastuzumab in the treatment of HER2 positive breast cancer. Histology and Histopathology, 35(10), 1059-1075. https://doi.org/10.14670/HH-18-221

Mesenchymal stem cell-based Smad7 gene therapy for experimental liver cirrhosis

Su, D., Wu, S., & Xu, S. (2020). Mesenchymal stem cell-based Smad7 gene therapy for experimental liver cirrhosis. Stem Cell Research and Therapy, 11(1), Article 395. https://doi.org/10.1186/s13287-020-01911-4

TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility

Farmer, L., Rollason, R., Whitcomb, D., Ni, L., Goodlif, A., Lay, A., …Welsh, G. (2019). TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility. Journal of the American Society of Nephrology : JASN, 30(10), 1910-1924. https://doi.org/10.1681/ASN.2018070729

T-type Ca 2+ channel blocker mibefradil blocks ORAI channels via acting on extracellular surface

Li, P., Rubaiy, H. N., Chen, G., Hallett, T., Zaibi, N., Zeng, B., …Xu, S. (in press). T-type Ca 2+ channel blocker mibefradil blocks ORAI channels via acting on extracellular surface. British Journal of Pharmacology, https://doi.org/10.1111/bph.14788

Research interests

Ca2+ signalling; ion channels; vascular diseases; diabetic complications; drug discovery

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