Dr Leigh Madden

Dr Leigh Madden

Post-Doctoral Research Assistant

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Summary

Leigh came to the University of Hull to study Applied Biology in 1991. He specialised in biotechnology in the final year of his degree and then proceeded to continue into a research career starting with PhD and postdoctoral positions fully funded through industry (Monsanto Inc, USA). Following this he switched fields into medical research in 2000 and has been at Hull ever since. Leigh is an author on over 100 peer-reviewed papers which have been cited over 3500 times (h-index 36), covering a wide range of interests and has worked closely with clinical leads, colleagues in HYMS, Chemistry and Sport Health and Exercise Science as well as commercial partners from City Healthcare Partnership, North of England Medical Hyperbaric Services, Mimir Marine and QinetiQ.

Leigh has helped supervise many students across a wide range of research fields including cancer associated coagulation, diabetes, polycystic ovary syndrome, bioimprinting, tissue engineering, decompression sickness, exercise in clinical populations to clinical trials of investigative medicinal products (CTIMPs) and App development.

Recent outputs

View more outputs

Journal Article

Early Human Pathophysiological Responses to Exertional Hypobaric Decompression Stress

Connolly, D., Madden, L., Edwards, V., D'Oyly, T., Harridge, S., Smith, T., & Lee, V. (2023). Early Human Pathophysiological Responses to Exertional Hypobaric Decompression Stress. Aerospace Medicine and Human Performance, 94(10), 738-749. https://doi.org/10.3357/AMHP.6247.2023

Coagulation Profiles in Humans Exposed to Exertional Hypobaric Decompression Stress Determined by Calibrated Automated Thrombogram

Madden, L. A., Vince, R. V., Edwards, V. C., Lee, V. M., & Connolly, D. M. (2023). Coagulation Profiles in Humans Exposed to Exertional Hypobaric Decompression Stress Determined by Calibrated Automated Thrombogram. Hemato, 4(4), 301-310. https://doi.org/10.3390/hemato4040024

Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites

Doyle, B., Madden, L. A., Pamme, N., & Jones, H. (2023). Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites. RSC advances, 13(40), 27696-27704. https://doi.org/10.1039/d3ra03742h

Digital Health Solutions for Weight Loss and Obesity: A Narrative Review

Irvin, L., Madden, L. A., Marshall, P., & Vince, R. V. (2023). Digital Health Solutions for Weight Loss and Obesity: A Narrative Review. Nutrients, 15(8), Article 1858. https://doi.org/10.3390/nu15081858

Fabrication of Angiogenic Sprouting Coculture of Cell Clusteroids Using an Aqueous Two-Phase Pickering Emulsion System

Wang, A., Madden, L. A., & Paunov, V. N. (2022). Fabrication of Angiogenic Sprouting Coculture of Cell Clusteroids Using an Aqueous Two-Phase Pickering Emulsion System. ACS Applied Bio Materials, https://doi.org/10.1021/acsabm.2c00168

Research interests

Leigh’s main research interest lies within the field of extracellular vesicles in which he has been actively conducting and publishing research since 2003 when he was part of the first ever study investigating the role of extracellular vesicles in decompression sickness. Always keen to contribute to new research Leigh has collaborated across a wide spectrum of projects within the medical field.

Co-investigator

Project

Funder

Grant

Started

Status

Project

Assessing the health economics of two home-based exercise programmes in obese adults

Funder

NHS East Riding of Yorkshire Clinical Commissioning Group

Grant

£9,921.00

Started

1 June 2018

Status

Complete

Postgraduate supervision

Extracellular vesicles – clinical and/or laboratory based

Cancer associated hypercoagulability – clinical and/or laboratory based

Bioimprinting – laboratory based

Tissue engineering – laboratory based

Diabetes, Obesity and Polycystic ovary syndrome – clinical and/or laboratory based

Clinical role

Good Clinical Practice (GCP) | NIHR

2006

Good Clinical Practice (GCP) is the international ethical, scientific and practical standard to which all clinical research is conducted. It is important that everyone involved in research is trained or appropriately experienced to perform the specific tasks they are being asked to undertake. GCP training is a requirement set out in the UK Policy Framework for Health and Social Care Research developed by the Health Research Authority for researchers conducting clinical trials of investigational medicinal products (CTIMPs).

Honorary Senior Researcher

2004

All terms and conditions for this contract extension remain as per the initial honorary contract issued to you on the 21st June 2004 by Hull University Teaching Hospitals NHS Trust.

Journal editorial role

Guest Editor of the Special Issue entitled "Cancer Associated Coagulation" in Hemato (ISSN 2673-6357)

2021

This Special Issue aims to encompass research in all aspects of cancer-associated coagulation, from understanding the mechanisms of tumour-driven hypercoagulopathy to advances in anticoagulant treatment and patient management. Certain tumours, such as those of the pancreas and ovaries, are associated with an increased risk of the patient developing venous thromboembolism and this risk increases further with chemotherapy by mechanisms currently being investigated. Patients are managed with the use of anticoagulants such as low-molecular-weight heparin or orally administered alternatives. Of particular interest is the role of extracellular vesicles within these processes and also research investigating the impact of COVID-19, although studies on all aspects of cancer-associated coagulation are welcome.

Associate Editor for Frontiers in Physiology: Clinical and Translational Physiology

2021

Hemato

2020

Hemato (ISSN 2673-6357) publishes regular research papers, reviews, letters and communications covering all aspects of hematology, from pathogenesis to diagnosis and personalized management, through in vivo genomic and immunologic research. Our aim is to improve the study of clinical and basic research of blood-related diseases. It covers topics related to hematopathology from laboratory to clinical studies, and the prevention, diagnosis, and therapeutics of hematological diseases, including components such as blood cells, blood proteins, blood vessels, bone marrow and coagulation. Furthermore, it encompasses topics related to all blood diseases, such as blood cancers, bleeding disorders, and hemophilia. There is no restriction on the length of the papers or colors used. The method/approach must be presented in detail so that the results can be reproduced. There are, in addition, three unique features of this journal: Manuscripts regarding research proposals and research ideas are welcome Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material We also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds

Disease Markers

2014

Disease Markers is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the identification of disease markers, the elucidation of their role and mechanism, as well as their application in the prognosis, diagnosis and treatment of diseases.

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