Leonid Nikitenko

Dr Leonid Nikitenko

Lecturer in Biomedical Sciences

Faculty and Department

  • Faculty of Health Sciences
  • School of Life Sciences

Summary

Dr Leonid Nikitenko is an endothelial cell biologist. His basic and clinical laboratory research is focused on characterising molecular mechanisms regulating endothelial cell function in cancer, cardiovascular disease and lymphoedema. Alumni from Dr Nikitenko's laboratory and his former tutees at the University of Hull are next generation biomedical scientists who now continue their careers at the Universities of Oxford, Warwick, Manchester and London or in hospitals, the pharmaceutical industry and biotech companies nationwide and abroad. Google Scholar ResearchGate ResearcherID

Undergraduate

MSc Level 7 ● Research Project and Dissertation ● Tumour Immunology and Microenvironment ● Research Skills in Oncology and Biomedical Science ● Current Topics in Biomedical Science ● Tumour Immunology and Microenvironment BSc Level 6 ● Cancer Biology (module coordinator) ● Research Project and Dissertation (20 and 40 credit) ● Cellular Pathology ● Reviews of Biology and Biomedical Sciences Level 5 ● Biological Basis of Disease ● Professional and Research Skills for Biomedical Sciences and Human Biology Level 4 ● Cell Structure and Function (module coordinator) ● Skills for Biomedical Sciences and Human Biology

Journal Article

Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms

Featherby, S., Xiao, Y. P., Ettelaie, C., Nikitenko, L. L., Greenman, J., & Maraveyas, A. (2019). Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms. Scientific reports, 9(1), https://doi.org/10.1038/s41598-019-42738-1

MEF2 transcription factors are key regulators of sprouting angiogenesis

Sacilotto, N., Chouliaras, K. M., Nikitenko, L. L., Lu, Y. W., Fritzsche, M., Wallace, M. D., …De Val, S. (2016). MEF2 transcription factors are key regulators of sprouting angiogenesis. Genes & development, 30(20), 2297-2309. https://doi.org/10.1101/gad.290619.116

Postgraduate supervision

Applications from prospective PhD or MSc by Research (MRes) students wishing to join Dr Nikitenko's research group and thriving postgraduate community at the School of Life Sciences are welcome at any time. In particular, Dr Nikitenko invites expression of interest and applications in the following areas of research. - Novel molecular mechanisms regulating endothelial cells differentiation, angiogenesis and lymphatic function in health and disease. - G-protein coupled receptors as targets for imaging and therapy in cardiovascular disease, cancer and lymphoedema. - Next generation sequencing and bioinformatics approaches to study endothelial and cancer cell biology. - Three-dimensional models and gene editing to study the role for tumour microenvironment in cancer progression. - Vasoactive and angiogenic peptides and their receptors. - Matricellular proteins and their role in cancer progression and resistance to therapies. - Lymphatic system and pathogenesis of lymphedema. - Cancer progression and resistance to targeted (including anti-angiogenic) therapies in renal carcinoma and sarcoma. - Intra- and inter-tumour heterogeneity.