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Dr Laura Sadofsky

Lecturer in Respiratory Medicine/ Academic lead for postgraduate training in HYMS

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Summary

Laura Sadofsky is interested in ion channels and their role in cough and airways inflammation. Her laboratory is currently using human cells and tissue to develop models of the human airways. Using these models, she hopes to better understand the changes which occur in the airways in response to viruses as well as environmental stimuli and pharmaceuticals.

Undergraduate

MSc Physician Associate Studies - Pharmacology, Prescribing and Therapeutics MBBS Medicine - Phase 1 plenary lectures BSc/MSc Biomedical Science - Research projects

Journal Article

N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites

Chandrabalan, A., McPhillie, M. J., Morice, A. H., Boa, A. N., & Sadofsky, L. R. (2019). N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites. European Journal of Medicinal Chemistry, https://doi.org/10.1016/j.ejmech.2019.02.074

Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria

Vance, J., Santos, A., Sadofsky, L., Morice, A., & Cervantes, J. (2019). Effect of high glucose on human alveolar macrophage phenotype and phagocytosis of mycobacteria. Lung, 197(1), 89–94. doi:10.1007/s00408-018-0181-z

Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF)

Vancauwenberghe, E., Noyer, L., Derouiche, S., Lemonnier, L., Gosset, P., Sadofsky, L. R., …Roudbaraki, M. (2017). Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF). Molecular Carcinogenesis, 56(8), 1851-1867. https://doi.org/10.1002/mc.22642

Lipid laden macrophages in respiratory disease

Sadofsky, L. R., Hayman, Y. A., Hart, S. P., & Morice, A. H. (2017). Lipid laden macrophages in respiratory disease. Journal of Neurogastroenterology and Motility, 23(3), 477-478. https://doi.org/10.5056/jnm17036

The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration?

Hayman, Y. A., Sadofsky, L. R., Williamson, J. D., Hart, S. P., & Morice, A. H. (2017). The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration?. Ers Monograph, 3(1), 00026-2016. https://doi.org/10.1183/23120541.00026-2016

Postgraduate supervision

Ion channels including the thermo-Transient Receptor Potential (TRP) cation channels TRPA1, TRPV1, TRPV4 and TRPM8 (TRP ankyrin-1, vanilloid-1, vanilloid-4 and melastatin-8) and purinergic receptors P2X2 and P2X3 - Biomedical Microfluidics - Precision Cut Lung Slices (PCLS) - Human rhinovirus - Cough and airways inflammation Completed PhDs Knaggs J D, The Modulation of Transient Receptor Potential A1 Channel by Natural and Novel Semi-synthetic Compounds via Non-covalent Modification (2016). Fraser S D, Peripheral Blood Leukocyte Immune Responses in Sarcoidosis (2016) Current PhDs - Samantha Atkinson - Arundhasa Chandrabalan - Rebecca Stinson