PET scanner

Positron Emission Tomography Research Centre

The University of Hull PET Research Centre is a medical-imaging research facility. Our mission is to improve both the availability and the capabilities of nuclear imaging of cancer and cardiac disease.

Molecular imaging with PET lets us detect the molecular processes that underpin disease without the need for invasive surgery. It means therapy can be stratified to the patients who stand the best chance of responding.

PET can also be used to detect whether patients are responding to therapy early on, allowing treatment to be altered quickly if it is of little or no benefit.

Steve Archibald-min
Faculty of Science and Engineering
Prof Steve Archibald
Director Positron Emission Tomography group

The Challenge

The University of Hull PET Research Centre is a medical-imaging research facility. Our mission is to improve both the availability and the capabilities of nuclear imaging of cancer and cardiac disease.

Our specific aims are to validate novel PET radiotracers and enable their translation into the clinic, as well as extend the application of existing PET radiotracers to the management of disease.

The Approach

The University of Hull is the only UK site to have a research-dedicated cyclotron for preclinical research. This allows us to focus on new tracer development and the delivery of research projects with academic and industrial partners.

The PET Research Centre is linked with the Jack Brignall PET-CT centre at Hull's Castle Hill Hospital, which houses a Siemens Biograph mCT Flow Edge PET-CT scanner and will house a groundbreaking dose-on-demand cyclotron facility based around a GE GENTrace cyclotron.

PET lab

OUR AIMS

  • to develop novel radiotracers for PET/SPECT imaging
  • to image established radiotracers to probe biological questions
  • to develop dose-on demand technologies to improve widespread international use of PET imaging

Projects

View all projects
  • PET imaging of nano/micro particles
  • Chemokine receptor imaging
  • Mitochondrial targeted PET/Optical agents
  • Dose-on-demand radiopharmaceuticals
  • Microfluidic tracer production
  • Imaging of tissue engineering constructs
  • PET imaging of photodynamic therapy
Members
Outputs and publications

Burke B P, Grantham W, Burke M J, Roberts D, Renard I, Hargreaves R, Cawthorne C, Archibald S J, Lusby P J, 'Visualising Kinetically Robust CoIII4L6 Assemblies In Vivo: SPECT Imaging of the Encapsulated 99mTcO4− Anion', Journal of the American Chemical Society, 140, pp 16877-17881 (2018)

Mastrogiacomo S, Kownacka A E, Dou W, Burke B P, de Rosales R T M, Heerschap A, Jansen A, Archibald S J, Walboomers X F, 'Gadolinium Oxide Nanoparticles Functionalised with Biphosphonate for Multimodal Imaging of Calcium Phosphate Cement', Advanced Healthcare Materials, 7, 1800202 (2018)

Burke B P, Cawthorne C, Archibald S J, 'Multimodal nanoparticle imaging agents: design and applications', Philosophical Transactions of the Royal Society A, 375, 20170261 (2107)

Burke B P, Cawthorne C, Archibald S J, 'Chapter 25: Radionuclide Labelling and Imaging of Magnetic Nanoparticles', in Clinical Applications of Magnetic Nanoparticles, Nguyen Thanh (ed), CRC Press, ISBN 9781138051553 (2017)

Voulgari E, Bakandritsos A, Galtsidis S, Zoumpourlis V, Burke B P, Clemente G S, Cawthorne C, Archibald S J, Tucek J, Zboril R, Kantarelou V, Karydas A, Winnefeld F, Avgoustakis K, 'Synthesis, Characterisation and in vivo Evaluation of a Magnetic Cisplatin Delivery Nanosystem Based on PMAA-graft-PEG Copolymers', Journal of Controlled Release, 243, 342 (2016)

6. R. D. Maples, A. N. Cain, B. P. Burke, J. D. Silversides, R. Mewis, T. D’huys, D. Schols, D. P. Linder, S. J. Archibald, T. J. Hubin, Modelling aspartate based CXCR4 receptor binding of cross-bridged tetraazamacrocyclic copper(II) and zinc(II) complexes, Chem. Eur. J., 2016, 22, 129116.

7. P. He, B. P. Burke, G. S. Clemente, N. Brown, N. Pamme, S. J. Archibald, Monolith-based 68Ga processing – a new strategy for purification of generator eluate to facilitate direct radiolabelling methods, React. Chem. Eng., 2016, 1, 361.

8. S. Nigam, B. P. Burke, L. H. Davies, J. Domarkas, J. Waby, A. M. Seymour, C. Cawthorne, L. J. Higham, S. J. Archibald, Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells, Chem. Comm., 2016, 52, 7114.

9. B. P. Burke, N. Baghdadi, A. E. Kownacka, S. Nigam, G. S. Clemente, M. Al-Yassiry, J. Domarkas, M. Lorch, M. Pickles, P. Gibbs, R. Tripier, C. Cawthorne, S. J. Archibald, Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions, Nanoscale, 2015, 7, 14889.

10. B. P. Burke, G. S. Clemente, S. J. Archibald, Boron-18F containing positron emission tomography radiotracers: Advances and Opportunities, Contrast Media Mol. Imaging, 2015, 10, 96.

Research Students

Hayley Bignell

Rebecca Hargreaves

Tom Price

Jordon Sandland

Tahani Al-Resheedi

Fada Jabber

Isaline Renard

Noemi Perujo-Holland

Glenn Woolley

Vincent Nail

George Herbert

Eva Sousa

Max Palmer

Inspired?

Our research impacts the world. Come and join us.

Be part of a vibrant research community at the University of Hull.

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