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Cognitive and Clinical Neuroscience

Dr Henning Holle
Faculty of Health Sciences
Dr Henning Holle
Senior Lecturer in Psychology

The Challenge

We aim to understand the biological processes underlying cognition and perception, how these processes are established, how they differ in (a-)typically developing populations, and whether they are critically linked to particular brain areas.

The Approach

Members of the group use electrophysiological (EEG), neuroimaging (fMRI/fNIRS) as well as neuromodulatory methods (TMS/tDCS). These studies take place in research laboratories in the Department of Psychology as well via existing collaborations with the Hull and East Riding Hospitals NHS Trust.

Brain measurement

OUR AIMS

  • To investigate the fundamental biological processes that underpin human cognition and perception
  • To identify brain areas causally involved in psychological processes
  • To study how these processes become established and change over time and as a consequence of disease
  • To investigate the potential benefit of brain stimulation methods for mitigating disease-related symptoms and enhancing cognition

Projects

Gesture

Functional neuroanatomy of Language, Gesture and Action

Our research focuses on the brain processes underpinning language, gesture and action. Examples include neural bases of gesture-speech integration, the role of co-speech gesture in second language acquisition and neural correlates of action prediction and anticipation.

Model skull

Clinical neuroscience of itch perception

We aim to identify brain regions critically involved in the perception of itch, as well as investigating whether itch intensity can be reduced via modulating brain activity or modulating sensory information.

Group

Cognitive Neuroscience of Social cognition

This project investigates the brain processes and mechanisms underpinning social perception, social interaction and the processing of emotions. Current projects are concerned with theory of mind in people with autism as well as the neural basis of action prediction/anticipation in autism.

Outreached hand

Neural architecture of space representation

This theme focuses on the neural representation of far space (the space outside arm-reaching distance) vs near space (the space within arm-reaching distance). Our research takes a two-tiered approach, involving neuropsychological testing of patients with visuospatial neglect as well as virtual-lesion approaches using neuromodulatory methods such as TMS and tDCS.

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Functional neuroanatomy of language, gesture and action (Holle, Schindler, Riggs, O'Connor, Jellema)

Our research focuses on the brain processes underpinning language, gesture and action. Examples include neural bases of gesture-speech integration (Holle, Schindler, Riggs), the role of co-speech gesture in second language acquisition (Holle, O'Connor) and neural correlates of action prediction and anticipation (Jellema, Schindler).

Clinical neuroscience of itch perception (Holle, Schindler, George)

We aim to identify brain regions critically involved in the perception of itch, as well as investigating whether itch intensity can be reduced via modulating brain activity (Holle, Schindler) or modulating sensory information (Holle, George).

Cognitive neuroscience of social cognition (Jellema, Schindler, Riggs, O'Connor)

This project investigates the brain processes and mechanisms underpinning social perception, social interaction and the processing of emotions. Current projects are concerned with theory of mind in people with autism (Jellema, Riggs, O'Connor) as well as the neural basis of action prediction/anticipation in autism (Jellema, Schindler).

Neural architecture of space representation (Schindler, Riggs, Large)

This theme focuses on the neural representation of far space (the space outside arm-reaching distance) vs near space (the space within arm-reaching distance). Our research takes a two-tiered approach, involving neuropsychological testing of patients with visuospatial neglect (Schindler) as well as virtual-lesion approaches using neuromodulatory methods such as TMS and tDCS (Schindler, Riggs, Large).

Members

Outputs and publications

Boland, J., Riggs, K. J., & Anderson, R. J. (2018). A brighter future: The effect of positive episodic simulation on future predictions in non-depressed, moderately dysphoric & highly dysphoric individuals. Behav Res Ther, 100, 7-16. doi: 10.1016/j.brat.2017.10.010

Coleshill, M. J., George, D. N., & Mazzoni, G. (2017). Placebo Analgesia From a Rubber Hand. J Pain, 18(9), 1067-1077. doi:10.1016/j.jpain.2017.04.004

Eimontaite, I., Goel, V., Raymont, V., Krueger, F., Schindler, I., & Grafman, J. (2018). Differential roles of polar orbital prefrontal cortex and parietal lobes in logical reasoning with neutral and negative emotional content. Neuropsychologia. doi: 10.1016/j.neuropsychologia.2018.05.014

Palumbo, L., Macinska, S.T., & Jellema, T. (2018). The role of pattern extrapolation in the perception of dynamic facial expressions in Autism. Frontiers in Psychology, 9, Article number 1918DOI: 10.3389/fpsyg.2018.01918

Rowley, D. A., Rogish, M., Alexander, T., & Riggs, K. J. (2018). Counter-intuitive moral judgement following traumatic brain injury. J Neuropsychol, 12(2), 200-215. doi: 10.1111/jnp.12117

Jones, O., Schindler, I., & Holle, H. (2018). Transcranial magnetic stimulation over contralateral primary somatosensory cortex disrupts perception of itch intensity. Exp Dermatol. doi: 10.1111/exd.13803

Zhao, W., Riggs, K., Schindler, I., & Holle, H. (2018). Transcranial Magnetic Stimulation over Left Inferior Frontal and Posterior Temporal Cortex Disrupts Gesture-Speech Integration. J Neurosci, 38(8), 1891-1900. doi: 10.1523/jneurosci.1748-17.2017

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Research Students

Zoe Lewis

A multisensory approach to itch

Dr Henning Holle (primary supervisor), Dr David George (co-supervisor)

Sarah Etty

An attentional bias approach to psoriasis

Dr Henning Holle (primary supervisor), Dr David George (co-supervisor)

Joana López Pigüi

Cortical oscillations related to predicting and observing actions

Dr Tjeerd Jellema (primary supervisor), Dr Igor Schindler (co-supervisor)

Lee Parkin

Neural architecture of space representation

Dr Igor Schindler (primary supervisor), Dr Kevin Riggs (co-supervisor), Dr Mary-Ellen Large (co-supervisor)