About this project
Brain tumour biopsies maintained on-chip provide a platform that can enable fundamental investigations of novel diagnostic and clinically relevant treatment strategies, based on novel drugs and directed at individual tumours. The overarching aim of this project is to assess the effect of treating brain tumour biopsies, maintained in a novel microfluidic device, with established and new therapies and to investigate the mechanisms underlying that effect.
You will use aseptic techniques, including cell culture and microfluidics, to maintain brain tumour biopsies and you will analyse the effect of drugs on biopsies using a range of techniques such as immunohistochemistry, western blotting, and other biochemistry and molecular biology analysis.
This is a collaboration between the University of Hull and the University of Leeds, funded by Brain Tumour Research and Support across Yorkshire (BTRS). You will be based at the University of Hull under the primary supervision of Dr Pedro Beltran-Alvarez and you will have joint second supervisors in Dr Mark Wade (University of Hull) and Dr Lucy Stead (University of Leeds).
The University of Hull is the 14th oldest University in England and the Faculty of Health Sciences is based at the award-winning Allam Medical Building. The Faculty enables us to thrive in an outstanding research environment which has seen an investment of £28 million in the last few years. We enjoy fantastic research facilities including microfluidics, microscopy, mass spectrometry, PET imaging and flow cytometry. You will join the Brain Tumour Research Group, which is headed by Prof John Greenman and brings together a unique concentration of expertise in cancer biochemistry, genetics and epigenetics, neurosurgery, immunology, biomarkers and therapeutic targets. The mission of the Brain Tumour Research Group is to investigate novel biomarkers, therapeutic targets and optimal treatment of brain tumours to enable earlier diagnosis, improved treatment and enhanced patient quality and quantity of life.
The research project has been designed jointly by the Hull and Leeds brain tumour research groups and builds on years of previous work at both sites. The PhD student will be trained to the highest standards to be a leader in the field.