Qualifications
- BSc (University of Manchester)
- PhD / DPhil (University of Glasgow)
Summary
Tim is Professor of Cardiovascular Biology and Head of the Centre for Biomedicine at Hull York Medical School.
Tim obtained an Honours degree in Biochemistry at the University of Manchester and a PhD in Molecular Pharmacology at the University of Glasgow. He carried out postdoctoral training as an American Heart Association Research Fellow in the Cardiology Division at Duke University Medical Centre, North Carolina, USA.
He returned to the UK in 1997 as a Lecturer in Biochemistry at the University of Glasgow and developed an externally funded research programme focusing on cardiovascular cell signalling and disease.
From 2015 he was Professor of Pharmacology and Head of Pharmacology and Experimental Therapeutics at the School of Pharmacy and Medical Sciences at the University of Bradford before taking up his position in Hull in 2018.
Journal Article
Defining the miRnome of Saphenous Vein Smooth Muscle Cells from Patients with Type 2 Diabetes Mellitus
Hussain, A., Asare-Amankwah, Y., Qureshi, S., Thornton, M. J., Palmer, T. M., Bolanle, I. O., Wood, I. C., Turner, N. A., Porter, K. E., Tedder, A., & Riches-Suman, K. (2024). Defining the miRnome of Saphenous Vein Smooth Muscle Cells from Patients with Type 2 Diabetes Mellitus. Diabetology, 5(2), 178-189. https://doi.org/10.3390/diabetology5020014
Do T2DM and Hyperglycaemia Affect the Expression Levels of the Regulating Enzymes of Cellular O-GlcNAcylation in Human Saphenous Vein Smooth Muscle Cells?
Bolanle, I. O., Durham, G., Hobkirk, J. P., Loubani, M., Sturmey, R. G., & Palmer, T. M. (2024). Do T2DM and Hyperglycaemia Affect the Expression Levels of the Regulating Enzymes of Cellular O-GlcNAcylation in Human Saphenous Vein Smooth Muscle Cells?. Diabetology, 5(2), 162-177. https://doi.org/10.3390/diabetology5020013
Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study
Rotchell, J. M., Jenner, L. C., Chapman, E., Bennett, R., Bolanle, I. O., Loubani, M., Sadofsky, L., & Palmer, T. (2023). Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study. PLoS ONE, 18(2), Article e0280594. https://doi.org/10.1371/journal.pone.0280594
Research interests
Professor Palmer’s interests are identifying the molecular mechanisms responsible for cardiovascular disease. Localised inflammation of branch points within large blood vessels is a pivotal event in the development of atherosclerotic plaque responsible for hear attack and stroke. Inflammation is driven by long-term exposure to chemical signals termed "cytokines" which trigger multiple pathways that ultimately lead to the defective vascular cell function responsible for cardiovascular disease. These processes are also responsible for the failure of bypass and stenting procedures used for acute treatment of patients who have suffered a heart attack.
Lead investigator
Project
Funder
Grant
Started
Status
Project
Wolfson Equipment bid 2023 - Confocal Imaging ZEISS Elyra 7 with Lattice SIM²
Funder
Wolfson Foundation
Grant
£500,000.00
Started
1 October 2024
Status
Ongoing
Project
SOCS VASC - Stabilising suppressor of cytokine signalling 3 (SOCS3) to limit vascular re-modelling in vein graft failure and in-stent restenosis
Funder
Hull & East Riding Cardiac Trust Fund
Grant
£39,323.00
Started
1 December 2019
Status
Complete
Project
: A Targeted Approach To Reduce Risk of Blood Clotting in MPN Patients
Funder
Hull University Teaching Hospitals NHS Trust
Grant
£30,000.00
Started
1 October 2023
Status
Complete
Project
HIKE: A Data Package to Support Clinical Translation of Novel Microwave Probes for Peripheral Arterial Disease (MICRO-PAD)
Funder
MRC Medical Research Council
Grant
£45,389.00
Started
1 November 2023
Status
Complete
Co-investigator
Project
Funder
Grant
Started
Status
Project
RISE: Establishing super-Resolution Imaging in Hull for impactful multimorbidity ReSEarch MRC Equipment bid 2024 - Confocal Imaging ZEISS Elyra 7 with Lattice SIM²
Funder
MRC Medical Research Council
Grant
£718,262.00
Started
1 October 2024
Status
Ongoing
Project
PreclinHUPET2: Enabling Enhanced Preclinical Nuclear Imaging For The North Of England
Funder
MRC Medical Research Council
Grant
£657,700.00
Started
1 February 2023
Status
Complete
Postgraduate supervision
Enquiries from prospective students welcome. 16 students successfully supervised to completion.
Current topics:-
1. Defining mechanisms linking anti-inflammatory signalling with protection of the vasculature from mechanical stress.
2. Identification of novel glucose-dependent alterations responsible for platelet dysfunction in Type 2 diabetes.
3. Defining the molecular basis for re-purposing anti-hyperglycaemic drugs to manage thrombosis in myeloproliferative neoplasm patients.