Dr Pedro Beltran-Alvarez

Dr Pedro Beltran-Alvarez

Lecturer in Biomedical Sciences

Faculty and Department

  • Faculty of Health Sciences
  • Department of Biomedical Sciences

Qualifications

  • PhD (University of Bristol)

Summary

Pedro did his PhD at the University of Bristol (2004-2007) funded by a Marie Curie grant from the EU. After a short stage in the European Molecular Biology Laboratory (EMBL, Heidelberg, 2007-2009), he joined the Cardiovascular Research Centre at the University of Girona (2009), where he gained a Sara Borrell Postdoctoral Fellowship from the Spanish Government (2011-2014). Pedro then joined the University of Hull in 2015 as a Lecturer in Biomedical Sciences.

Laboratory website: https://sites.google.com/view/beltran-alvarez-lab/home

Undergraduate

Pedro coordinates Biomedical Sciences modules on Biological Basis of Disease (Level 5) and Clinical Biochemistry (Level 6) and additionally teaches on a variety of modules including Biochemistry (L4), Nutrition (L5), Muscle Fitness and Failure (L6), Reviews in Biochemistry (L6), Current Topics in Biomedicine (L7) and Diseases in Biomedicine (L7).

Pedro also contributes to teaching of UG and PG students in modules including Skills for Biomedical Scientists and supervises UG and PG students during their final research projects.

Recent outputs

View more outputs

Journal Article

Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity

Sfyri, P. P., Yuldasheva, N. Y., Tzimou, A., Giallourou, N., Crispi, V., Aburima, A., …Matsakas, A. (2018). Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity. Free radical biology & medicine, 129, 504-519. https://doi.org/10.1016/j.freeradbiomed.2018.10.422

Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line

Samuel, S. F., Marsden, A. J., Deepak, S., Rivero, F., Greenman, J., & Beltran-Alvarez, P. (2018). Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line. Proteomes, 6(4), https://doi.org/10.3390/proteomes6040044

The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart

Onwuli, D. O., Samuel, S., Sfyri, P., Welham, K., Goddard, M., Abu-Omar, Y., …Beltran-Alvarez, P. (2019). The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart. International journal of cardiology, 282, 76-80. https://doi.org/10.1016/j.ijcard.2019.01.102

Mapping arginine methylation in the human body and cardiac disease

Onwuli, D. O., Rigau-Roca, L., Cawthorne, C., & Beltran-Alvarez, P. (2017). Mapping arginine methylation in the human body and cardiac disease. Proteomics. Clinical applications, 11(1-2), https://doi.org/10.1002/prca.201600106

Do sodium channel proteolytic fragments regulate sodium channel expression"

Onwuli, D. O., Yañez-Bisbe, L., Pinsach-Abuin, M., Tarradas, A., Brugada, R., Greenman, J., …Beltran-Alvarez, P. (2017). Do sodium channel proteolytic fragments regulate sodium channel expression?. Channels, 11(5), 476-481. https://doi.org/10.1080/19336950.2017.1355663

Research interests

Research Mission: to investigate protein post-translational modifications and hormones in cardiovascular and brain disease.

Research Vision: to develop ideas and biochemical tools that enable prevention, early diagnosis, monitoring and targeting of disease.

Current externally funded projects:

1. Role of arginine methylation of cardiac troponin I in cardiovascular disease, funded by The Hull and East Riding Cardiac Trust (HERCTF), £29,875. January-December 2019. Link to HERCTF: https://sites.google.com/view/herctf/home

2. Developing tissue-on-chip technology as a platform to measure the response of glioblastoma to established therapy and novel drugs (GBM-on-chip), funded by the Brain Tumour Research and Support across Yorkshire (BTRS), £79,987.75, 2020-2023. Link to BTRS: www.btrs.org.uk

Postgraduate supervision

Pedro proudly supervises students interested in biochemistry and post-translational modifications, in a variety of systems from cardiovascular to climate change models.

Current PG students include:

- Sabrina Samuel (3rd year PhD student), who is interested in brain disease

- Alistair Marsden (2nd year PhD student), who is interested in cardiovascular disease

- Lauric Feugere (2nd year PhD student, second supervisor), who is interested in stress signalling in fish in the context of climate change

- Srihari Deepak (MD student, second supervisor), who is a neurosurgeon at Hull University Teaching Hospitals NHS Trust

Past supervision: Dr Donatus Onwuli (graduated 2018)

CURRENT OPPORTUNITY:

We’re looking to recruit one PhD student to join our Brain Tumour Research Group.

Brain tumour biopsies maintained on-chip provide a platform that can enable fundamental investigations of novel diagnostic and clinically relevant treatment strategies, based on novel drugs and directed at individual tumours. The overarching aim of this project is to assess the effect of treating brain tumour biopsies, maintained in a novel microfluidic device, with established and new therapies and to investigate the mechanisms underlying that effect.

You will use aseptic techniques, including cell culture and microfluidics, to maintain brain tumour biopsies and you will analyse the effect of drugs on biopsies using a range of techniques such as immunohistochemistry, western blotting, and other biochemistry and molecular biology analysis.

This is a collaboration between the University of Hull and the University of Leeds, funded by Brain Tumour Research and Support across Yorkshire (BTRS). You will be based at the University of Hull under the primary supervision of Dr Pedro Beltran-Alvarez and you will have joint second supervisors in Dr Mark Wade (University of Hull) and Dr Lucy Stead (University of Leeds).

https://www.hull.ac.uk/study/postgraduate/research/phd/funded/biomedical-sciences-phd

Awards and prizes

Fellow of HEA

2016

Honorary position

Honorary Consultant Endocrinologist, Hull University Teaching Hospitals NHS Trust

2019