- PhD (University of Bristol)
Pedro did his PhD at the University of Bristol (2004-2007) funded by a Marie Curie grant from the EU. After a short stage in the European Molecular Biology Laboratory (EMBL, Heidelberg, 2007-2009), he joined the Cardiovascular Research Centre at the University of Girona (2009), where he gained a Sara Borrell Postdoctoral Fellowship from the Spanish Government (2011-2014). Pedro then joined the University of Hull in 2015 as a Lecturer in Biomedical Sciences.
Laboratory website: https://sites.google.com/view/beltran-alvarez-lab/home
Some of the research that we do is in youtube: https://www.youtube.com/watch?v=1JtVvdFJsnc
Pedro coordinates Biomedical Sciences modules on Biological Basis of Disease (Level 5) and Clinical Biochemistry (Level 6) and additionally teaches on a variety of modules including Biochemistry (L4), Nutrition (L5), Muscle Fitness and Failure (L6), Reviews in Biochemistry (L6), Current Topics in Biomedicine (L7) and Diseases in Biomedicine (L7).
Pedro also contributes to teaching of UG and PG students in modules including Skills for Biomedical Scientists and supervises UG and PG students during their final research projects.
The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart
Onwuli, D. O., Samuel, S., Sfyri, P., Welham, K., Goddard, M., Abu-Omar, Y., …Beltran-Alvarez, P. (2019). The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart. International journal of cardiology, 282, 76-80. https://doi.org/10.1016/j.ijcard.2019.01.102
Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line
Samuel, S. F., Marsden, A. J., Deepak, S., Rivero, F., Greenman, J., & Beltran-Alvarez, P. (2018). Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line. Proteomes, 6(4), https://doi.org/10.3390/proteomes6040044
Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity
Sfyri, P. P., Yuldasheva, N. Y., Tzimou, A., Giallourou, N., Crispi, V., Aburima, A., …Matsakas, A. (2018). Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity. Free radical biology & medicine, 129, 504-519. https://doi.org/10.1016/j.freeradbiomed.2018.10.422
Do sodium channel proteolytic fragments regulate sodium channel expression?
Onwuli, D. O., Yañez-Bisbe, L., Pinsach-Abuin, M., Tarradas, A., Brugada, R., Greenman, J., …Beltran-Alvarez, P. (2017). Do sodium channel proteolytic fragments regulate sodium channel expression?. Channels, 11(5), 476-481. https://doi.org/10.1080/19336950.2017.1355663
Research Mission: to investigate the relevance of protein post-translational modifications in the biological response to environmental changes, with a focus on human health.
Current externally funded projects:
1. Role of arginine methylation of cardiac troponin I in cardiovascular disease, funded by The Hull and East Riding Cardiac Trust (HERCTF), £29,875. January-December 2019. Link to HERCTF: https://sites.google.com/view/hull-east-riding-cardiac-trust
2. Developing tissue-on-chip technology as a platform to measure the response of glioblastoma to established therapy and novel drugs (GBM-on-chip), funded by the Yorkshire Brain Tumour Charity (YBTC), £79,987.75, 2020-2023. Link to YBTC: www.btrs.org.uk
Internally funded projects:
the Happy Chemical Cluster!
Which is the role of arginine methylation of cardiac troponin I in cardiovascular disease?
Hull & East Riding Cardiac Trust Fund
1 January 2019
Pedro proudly supervises students interested in biochemistry and post-translational modifications, in a variety of systems from cardiovascular to climate change models.
Current PG students include:
- Sabrina Samuel (3rd year PhD student), who is interested in brain disease
- Alistair Marsden (2nd year PhD student), who is interested in cardiovascular disease
- Lauric Feugere (2nd year PhD student, second supervisor), who is interested in stress signalling in fish in the context of climate change
- Antonia Barry (1st year PhD student)
-Quentin Rodriguez (1st year PhD student)
Past supervision: Dr Donatus Onwuli (graduated 2018)