Dr Mauro Rinaldi

Dr Mauro Rinaldi

Lecturer in Biochemistry

Faculty and Department

  • Faculty of Science and Engineering
  • School of Natural Sciences

Qualifications

  • BSc
  • PhD / DPhil

Summary

PhD opportunity: Apply now

Fully-funded PhD opportunity in my lab to work on making high-value chemicals from waste cellulose. Follow the link to apply:

https://www.hull.ac.uk/study/postgraduate/research/phd/funded/high-value-chemical-production-from-waste-cellulose

2023-present. Lecturer in Biochemistry, University of Hull.

2023-present. Visiting Research Fellow, The University of Manchester.

2021-2023. Research Fellow, The University of Manchester.

2018-2021. Postdoctoral Research Associate, The University of Manchester.

2017-2018. Postdoctoral Research Associate, The University of York.

2016-2017. Postdoctoral Research Associate, Rice University.

2010-2016. Postgraduate Research Student, Rice University.

2008-2010. Undergraduate Researcher, Faculty of Pharmacy and Biochemistry, University of Buenos Aires.

2006-2008. Undergraduate Researcher, IBYME, CONICET.

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My unique background comprises cell biology, specifically how subcellular compartments are made, with making high-value chemicals with microbes. I am now combining these fields of expertise to create synthetic organelles for biomanufacturing and other applications in biotechnology.

As an undergraduate student, my passion for biology took me to work and produce a BSc thesis on producing valuable sterols with the microorganisms Saccharomyces cerevisiae and Tetrahymena thermophila at the Department of Industrial Microbiology and Biotechnology (now Nanobiotech) in the Faculty of Pharmacy and Biochemistry of the University of Buenos Aires (Poklepovich, Rinaldi, et al. 2012 Steroids).

I then obtained my PhD with Prof Bonnie Bartel, member of the US National Academy of Sciences, at Rice University, Houston TX, USA. Here, I tackled an ambitious genetic screen to isolate and identify 35 novel alleles in 15 genes associated with plant peroxisomes and lipid bodies, including finding a new role for a predicted pectin methylesterase in lipid body mobilisation (Rinaldi et al., 2016 Genetics). I also published on the first partial loss-of-function alleles of the conserved PEX1 gene (Rinaldi et al., 2017 Plant Phys) and contributed to the first description of peroxisome-specific autophagy in plants (Farmer, Rinaldi et al., 2013 Plant Cell).

During my postdoctoral experience at the University of York under the supervision of Prof Ian Graham FRS, I reconstituted the biosynthetic pathway of the antimalarial artemisinin in tobacco leaves under the Artemisia project. I also contributed to a publication on the antimalarial action of Artemisia annua plant preparations (Czechowski*, Rinaldi* et al., 2019 Front Plant Sci, *authors contributed equally) that was cited by the World Health Organization (The use of non-pharmaceutical forms of Artemisia, 2019).

At the Manchester Institute of Biotechnology at The University of Manchester, I worked under the supervision of Prof Nigel Scrutton FRS on the Waste-to-Wealth project making high-value chemicals from paper waste in collaboration with Indian partners towards sustainable chemical manufacturing (Rinaldi et al., 2022 Front Bioeng Biotechnol). I then became a Research Fellow at Future Biomanufacturing Research Hub, further addressing two key challenges in Engineering Biology for biomanufacturing: converting abundant cellulosic material into an accessible carbon source through microbial digestion, and engineering stable strains that produce high-value chemicals to high titres. Here I learned that high-value chemical titres reach a maximum, and my experience suggests that chemical toxicity and lack of compartmentalisation in microbes limit titres (Rinaldi et al., 2022 Nat Prod Rev).

I have thus trained my skills in molecular and cell biology, protein biochemistry, genetics, plant biology, biotechnology, and fermentation science, among others. I have thus also gathered a wide network of academic collaborators and industrial partners in Europe, the US, Argentina, India and around the world. As a Lecturer, I will leverage my valuable skills, insights, and networks to create synthetic organelles to address unmet needs in biotechnology with academic and industrial impact.

Metabolism (L5)

2023. Senior Fellow of the Higher Education Academy.

2020. Fellow of the Higher Education Academy.

I also support, mentor and assess HEA applications; get in touch to learn more, get experience and obtain recognition at your level.

Recent outputs

View more outputs

Journal Article

Bioproduction of Linalool From Paper Mill Waste

Rinaldi, M. A., Tait, S., Toogood, H. S., & Scrutton, N. S. (2022). Bioproduction of Linalool From Paper Mill Waste. Frontiers in Bioengineering and Biotechnology, 10, Article 892896. https://doi.org/10.3389/fbioe.2022.892896

Alternative metabolic pathways and strategies to high-titre terpenoid production in: Escherichia coli

Rinaldi, M. A., Ferraz, C. A., & Scrutton, N. S. (2022). Alternative metabolic pathways and strategies to high-titre terpenoid production in: Escherichia coli. Natural Product Reports, 39(1), 90-118. https://doi.org/10.1039/d1np00025j

Flavonoid Versus Artemisinin Anti-malarial Activity in Artemisia annua Whole-Leaf Extracts

Czechowski, T., Rinaldi, M. A., Famodimu, M. T., Van Veelen, M., Larson, T. R., Winzer, T., …Graham, I. A. (2019). Flavonoid Versus Artemisinin Anti-malarial Activity in Artemisia annua Whole-Leaf Extracts. Frontiers in Plant Science, 10, Article 984. https://doi.org/10.3389/fpls.2019.00984

The PEX1 ATPase stabilizes PEX6 and plays essential roles in peroxisome biology

Rinaldi, M. A., Fleming, W. A., Gonzalez, K. L., Park, J., Ventura, M. J., Patel, A. B., & Bartel, B. (2017). The PEX1 ATPase stabilizes PEX6 and plays essential roles in peroxisome biology. Plant Physiology, 174(4), 2231-2247. https://doi.org/10.1104/pp.17.00548

The roles of β-oxidation and cofactor homeostasis in peroxisome distribution and function in Arabidopsis thaliana

Rinaldi, M. A., Patel, A. B., Park, J., Lee, K., Strader, L. C., & Bartel, B. (2016). The roles of β-oxidation and cofactor homeostasis in peroxisome distribution and function in Arabidopsis thaliana. Genetics, 204(3), 1089-1115. https://doi.org/10.1534/genetics.116.193169

Research interests

PhD opportunity: Apply now

Fully-funded PhD opportunity in my lab to work on making high-value chemicals from waste cellulose. Follow the link to apply:

https://www.hull.ac.uk/study/postgraduate/research/phd/funded/high-value-chemical-production-from-waste-cellulose

Synthetic organelles for applications in biotechnology

Postgraduate supervision

I welcome MSc and PhD applicants to my exciting future projects or your own ideas. Email me for guidance.

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Synthetic organelles

We know a lot about how subcellular compartments work and are created, but can we create them from scratch? Join me on projects in synthetic organelles for applications in biotechnology.

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Biomanufacturing

Making high-value chemicals from microbes, pushing titres to achieve commercial feasibility by handling toxicity.

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Renewable carbon

We desperately need to replace petrochemicals as feedstocks in bio-based processes with renewable carbon to combat climate change and reach Net Zero. Join me in exploring new solutions to a persistent challenge.

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I have experience mentoring undergraduate, MSc and PhD students, who were authors in my publications and moved on to successful careers in academia and biotech.

Committee/Steering group role

Biochemical Society Member of Research Area IV (Cells)

2023 - 2025

Research Area IV - Cells Research Area IV covers the broad areas of lipids, organelles, trafficking, protein turnover, cytoskeleton, cell cycle, cell adhesion and migration, phagocytosis, apoptosis, matrix biology, neurotransmitters, structures, cell walls, nuclear motors, glycobiology, glycosylation, micro-organisms, membrane fusion, synaptic function, ion channels, neuronal signalling, exocytosis, endocytosis and secretion.

Conference organisation

Symposium on Sustainability Assessment

2020

•Set up collaboration with academics across five departments at UoM •Co-wrote an application and secured funding •Co-organised full day interdisciplinary event with multiple talks by experts and ECRs on bioprocesses development, techno-economical analysis and life cycle analysis towards Sustainability •Presentations and attendance across five departments: Chemistry; Chemical Engineering; Mechanical, Aerospace and Civil Engineering; Earth and Environmental Science; Electrical and Electronic Engineering •Attended by 60 people and obtained excellent feedback •Set foundation for future sustainability network and follow-on funding

Membership/Fellowship of professional body

Senior Fellow of the Higher Education Academy

2023

Member of the Royal Society of Biology

2023

Fellow of the Higher Education Academy

2020

National/International learned society/body role

Biochemical Society Early Career Member

2022 - 2023

Other

Managing at Manchester for Researchers - ILM certification

2022

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