Mark Pearson

Professor Mark Pearson

Professor in Implementation Science

+44 (0)1482 463335 | Mark.Pearson@hull.ac.uk

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Related groups

  • Wolfson Palliative Care Research Group

Qualifications

  • PhD / DPhil

Summary

I research and teach on how to get the best of what we know delivered in routine practice, with a focus on palliative care & advanced illness and its intersections with the wider health and social care system. Seeing research and practice as intrinsically interlinked, my teaching and supervision develops practitioner and researcher mobility across disciplines and sectors so that knowledge travels to where it is needed. I have a particular interest in the application and methodological development of Realist research and other approaches that work with complexity.

Before entering research, I worked clinically as an Adult Nurse in acute medicine, rehabilitation, and medical oncology, moving to social science research via an interlude exploring livelihoods in Northern Nigeria. My jump from practice to research was motivated by a desire to understand, and change, the many things that stop knowledge being used to inform practice.

My ESRC-funded doctorate investigated how knowledge was identified and used in Public Health guideline development at the (as it then was) National Institute for Health & Clinical Excellence (NICE), challenging the view that only certain, narrowly-defined forms of evidence inform guideline development. Subsequently, my research career at University of Exeter Medical School and NIHR CLAHRC for the southwest peninsula (PenCLAHRC) has been applied (conducting systematic reviews to inform Public Health guideline development), methodological (developing realist synthesis for explaining implementation challenges), and developmental (engaging stakeholders in thinking through implementation questions and how research can help).

Critically applying Implementation Science has meant crossing conventional sectoral boundaries, with my research including covering diverse areas such as offenders’ mental health, health promotion in schools, and intermediate care. Working in this way gives rise to challenges that are not unlike those that ethnographers encounter where they are simultaneously an ‘insider’ and an ‘outsider’. Embracing this insider/outsider tension enables me to bring a distinct perspective.

Since joining the Wolfson Palliative Care Research Centre at Hull York Medical School in 2017, I have developed a programme of research in Implementation Science at the interfaces of health and social care relating to palliative care and advanced illness. Working in both effectiveness and theory-based paradigms, I have led studies and/or provided distinct implementation methods for research into the implementation of delirium management guidelines, breathlessness management, person-centred outcome measures, medicines optimisation, exercise programmes, and workforce wellbeing. Latterly, my work has turned towards directly informing policy through my role in the NIHR Policy Research Unit for Palliative and End of Life Care (with King’s College London) and developing local authority capacity to conduct and use research through the NIHR Health Determinants Research Collaboration North Yorkshire (co-led with North Yorkshire Council).

Undergraduate (MBBS):

- Phase 1 Scholarship & Special Interest Programme - Using Implementation Science to lead evidence-based change in health services

- Phase 2 Scholarship & Special Interest Programme

Postgraduate (Taught):

- Palliative Care: Implementing Best Practice (Programme Co-Director for PGCert/PGDip/MSc)

- Introduction to Implementation Science for palliative care and long-term conditions (Module Lead)

- Advanced Implementation Science for palliative care and long-term conditions (Module Lead)

Recent outputs

View more outputs

Journal Article

ERS guideline recommendation on airflow for breathlessness: the pitfalls of applying GRADE evidence ratings to complex non-pharmacological interventions

Luckett, T., Swan, F., Clark, J., Roberts, M., Pearson, M., Hutchinson, A., Currow, D., Kochovska, S., Crooks, M., Smith, T., & Johnson, M. (2025). ERS guideline recommendation on airflow for breathlessness: the pitfalls of applying GRADE evidence ratings to complex non-pharmacological interventions. European respiratory journal, 65(2), Article 2402244. https://doi.org/10.1183/13993003.02244-2024

Miriam Johnson Michael Crooks Joseph Clark Flavia Swan Ann Hutchinson

Antenatal pelvic floor muscle exercise intervention led by midwives in England to reduce postnatal urinary incontinence: APPEAL feasibility and pilot randomised controlled cluster trial

Macarthur, C., Bick, D., Salmon, V., Jones, E., Hay-Smith, J., Bishop, J., Gkini, E., Hemming, K., Webb, S., Pearson, M., Coleman, T., Terry, R., Edwards, E., Frawley, H., Oborn, E., & Dean, S. (2025). Antenatal pelvic floor muscle exercise intervention led by midwives in England to reduce postnatal urinary incontinence: APPEAL feasibility and pilot randomised controlled cluster trial. BMJ open, 15(1), Article e091248. https://doi.org/10.1136/bmjopen-2024-091248

Involving Patients and the Public in Cancer Associated Thrombosis Research: a strategy for success.

Edwards, M., Seddon, K., Baddeley, E., Ording, A. G., Pearson, M., Mahe, I., Mooijaart, S., Klok, F. A., Noble, S. I., & on behalf of the SERENITY consortium. (2025). Involving Patients and the Public in Cancer Associated Thrombosis Research: a strategy for success. Thrombosis journal, 18, Article 100196. https://doi.org/10.1016/j.tru.2024.100196

Midwifery-led antenatal pelvic floor muscle exercise intervention to reduce postnatal urinary incontinence: APPEAL research programme including a feasibility and pilot cluster RCT

Macarthur, C., Bick, D., Salmon, V., Jones, E., Hay-Smith, J., Bishop, J., Gkini, E., Hemming, K., Webb, S., Pearson, M., Coleman, T., Terry, R., Edwards, L., Frawley, H., Oborn, E., & Dean, S. (2024). Midwifery-led antenatal pelvic floor muscle exercise intervention to reduce postnatal urinary incontinence: APPEAL research programme including a feasibility and pilot cluster RCT. Programme Grants for Applied Research, 12(9), https://doi.org/10.3310/TJDH7946

Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer

Martens, E. S., Becker, D., Abele, C., Abbel, D., Achterberg, W. P., Bax, J. J., Bertoletti, L., Edwards, M. E., Font, C., Gava, A., Goedegebuur, J., Højen, A. A., Huisman, M. V., Kruip, M. J., Mahé, I., Mooijaart, S. P., Pearson, M., Seddon, K., Szmit, S., Noble, S. I., …Konstantinides, S. V. (2025). Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer. Thrombosis Research, 245, Article 109205. https://doi.org/10.1016/j.thromres.2024.109205

Research interests

I am a social scientist using theory-driven methods (in particular, Realist approaches) to conduct collaborative implementation research for intervention design and evaluation across health and social care, in particular palliative care.

Funded research projects:

2024-2028 Pearson, M., Murtagh, F., Johnson, M., Cohen, J., Huang, C., Taylor, P., Halliwell, J., O’Cathain, A., Roberts, H., May, P, Jackson, G., Agar, M. & Hosie, A. DAMPen-D II: Improving the Detection, Assessment, Management, and Prevention of Delirium in Palliative Care Units: a Cluster Randomised-Controlled Trial, Economic Analysis and Process Evaluation. NIHR Health & Social Care Delivery Research £2,504,125 (Co-Chief Investigator)

2024-2028 Pearson, M. & Needham, K., Murphy, R., Wood, J., Ling, R., Webb, R., Murtagh, F., Cook, J., Twiddy, M., Weatherly, H., Lorch, M. North Yorkshire Health Determinants Research Collaboration. NIHR Public Health Research. £5,050,482 (Co-Chief Investigator)

2024-2026 Sleeman, K., Murtagh, F., Higginson, I., Preston, N., Ziegler, L., Mitchell, S., Barclay, S., Cohen, J., Pearson, M., Kumar, R., Johnson, M. & May, P. NIHR Policy Research Unit for Palliative and End of Life Care. £2,999,938 (Co-Investigator)

2024-2026 Hutchinson, A., Crooks, M., Wright, C., Huang, C., Cohen, J., Pearson, M., Johnson, M., Hart, S. BREEZE 2: A randomised controlled trial of a complex intervention to manage breathlessness in pulmonary fibrosis. NIHR Research for Patient Benefit Award 206252 £499,973 (Co-Investigator)

2023-2024 Pearson, M., Swan, F., Hutchinson, A., Sartain, K. & Johnson, M. Living well with chronic breathlessness: Improving the sustained use of supported self-management strategies. NIHR Research for Patient Benefit Award 204312 £153,495 (Chief Investigator)

2023-2025 Crooks, M., Johnson, M., Swan, F., Hutchinson, A., Cohen, J., Huang, C., Pearson, M. & Wilkinson, A. Fan Feasibility Randomised Controlled Trial (RCT) for people living with COPD and high SABA intake (Fan FIRST). NIHR Research for Patient Benefit Award 204349 £249,404 (Co-Investigator)

2023-2024 Gridley, K., Wilberforce, M., Pearson, M., Clarke, C. & Creavin, S. Understanding the Role of 'Peer Tutors' in Post-Diagnostic Support for People with Dementia: A Realist Process Evaluation of the Good Life with Dementia Approach. NIHR School for Social Care Research £182,941 (Co-Investigator)

2022-2023 Johnson, M., Clark, J., Pearson, M., Spathis, A., Currow, D.C & Salins, N. BREATHE-INDIA: BREATHlEssness in INDIA - Development of a breathlessness beliefs and behaviour education intervention for use in the community-setting. MRC Public Health Intervention Development £109,723 (Co-Investigator)

2022-2024 Walker, E., Johnson, M., Wray, J., White, C., Bravington, A., Pearson, M., Taylor, P., Roberts, H., Manthorpe, J. & Hussain, J. Supporting, enabling and sustaining home care workers to deliver end-of-life care: a multiple-methods community-based case study. NIHR Health and Social Care Delivery Research (HSDR) £739,830 (Co-Investigator)

2022-2027 Klok, E., Noble, S., Soegard, M., Ording, A., Konstantinides, S., Teunissen, S., Mahe, I., Brun, M., Johnson, M., Murtagh, F., Maraveyas, A., Pearson, M., Hoffmann, I., Couffignal, C, Kruip, M. Towards cancer patient empowerment for optimal use of antithrombotic therapy at the end of life (SERENITY). EU-Horizon Europe €5,999,768 (Co-Investigator)

2022-2026 Forbes, C.. Johnson, M., Huang, C., Saxton, J., Cohen, J., Mitchell, E., Pearson, M., Twiddy, M., Lind, M., Young, R & Wilson, C. A phase II, randomised feasibility basket trial of a tailored, home-based exercise programme on disease-free survival among early stage high-risk recurring cancers in Yorkshire. Yorkshire Cancer Research £1,072,013 (Co-Investigator)

2022-2027 Spathis, A., Mant, J., Morris, S., Sutton, S., Booth, S., Lovick, R., Prevost, T., Higginson, I., Maddocks, M., Reilly, C., Armstrong, N., Evans, R., Farquhar, M., Pearson, M., Johnson, M. & Reeve, J. PrimaryBreathe: programme to develop and test a brief remote primary care intervention for chronic breathlessness. NIHR Programme Grant for Applied Research £2,416,792 (Co-Investigator)

2022-2023 Forbes, C., Johnson, M., Huang, C., Swan, F., Cohen, J., Pearson, M., Twiddy, M., Lind, M., Rawstorn, N. & Maddison, R. Adapting a smartphone-based rehabilitation programme for older adults living with and beyond cancer: an intervention development study using Intervention Mapping. NIHR Research for Patient Benefit £149,315 (Co-Investigator)

2022-2023 Murtagh, F., Johnson, M., Pearson, M., Hussain, J., Cohen, J., Clegg, A., Fraser, L., Ziegler, L., Farrin, A., Spilsbury, K., O’Cathain, A. Addressing Inequalities Across All Ages: The Yorkshire & Humber Palliative Care Research Network. National Institute for Health Research (NIHR) £99,932 (Co-Investigator)

2022-2024 Carrieri, D & Mattick, K., Pearson, M., Papoutsi, C. & Wong, G. Care Under Pressure 3: Optimising the delivery and impacts of interventions to reduce hospital doctors’ mental ill-health in the NHS. NIHR Health and Social Care Delivery Research (HSDR) Award 13/29/31 £569,919 (Co-Investigator)

2022-2023 Karkou, V., Kaehne, A., Omylinska-Thurston, J., Thurston, S. & Pearson, M. Arts for the Blues: Towards integrating the use of the arts in healthcare and cultural settings to tackle depression and improve wellbeing in the North West of England. UKRI Arts & Humanities Research Council (AHRC) £143,329 (Co-Investigator)

2021-2024 Bravington, A., Johnson, M., Boland, J., Pearson, M., Patterson, M., Lind, M. & Murtagh, F. Improving shared decision-making in malignant bowel obstruction: An exploration of context-specific treatment pathways and experiences to inform intervention development for person-centred care. Yorkshire Cancer Research £210,071 (Co-Investigator)

2021-2022 Pearson, M., Johnson, M., Boland, J., Allgar, V., Siddiqi, N. ‘Improving the detection, assessment, management, and prevention of delirium in Specialist Palliative Care Units’ Yorkshire Cancer Research TRANSFORM endowment fund £98,649 (Co-Chief investigator)

2021-2022 Maben, J., Mannion, R., Jones, A., Westbrook, J., Pearson, M., Wright, J. & Abrams, R. ‘Identifying interventions to reduce healthcare staff unprofessional behaviours: a realist synthesis’ NIHR Health Services & Delivery Research (HSDR)13/16/06 £274,801 (Co-investigator)

2021 Johnson, M., Daniel, S., Salins,N., Clark, J., Pearson, M., Currow, D. ‘Improving Appropriate Access and Availability of Opioids for Cancer-related Pain Control in India : bridging the gap between policy and practice’ Research England Global Challenges Research Fund 2021 £25,370 (Co-investigator)

2020-2021 Crooks, M., Pearson, M., Cohen, J. ‘The Sentinel Project: Collaborating to improve asthma care’ AstraZeneca £55,147 (Co-investigator)

2019-2024 Johnson, M., Murtagh, F., Currow, D., Pearson, M. & Walker, E. ‘Building critical mass for palliative care research through collaborative support, exchange and challenge’ Research England International Investment Initiative (I3) £403,510 (Co-investigator)

2018-2022 Johnson, M., Fallon, M., Currow, D., Norrie, J., Hall, P., Seymour, J., Chaudhuri, N., Bajwah, S., Keen, J., Higginson, I., Buchanan, D., Hart, S., & Pearson, M. (2018) ‘A parallel-group, double-blind, randomised, placebo-controlled trial comparing the effectiveness and cost-consequence and cost-effectiveness of low dose oral modified release morphine (MRM) versus placebo on the intensity of worst breathlessness in people with chronic breathlessness’ - NIHR Health Technology Appraisal (HTA) Award 17/34/01 (£1,380,693) (Co-investigator)

2017-2019 Mattick, K., Pearson, M., Wong, G., Carrieri, D., Papoutsi, C., Briscoe, S. & Jackson, M. (2017) ‘Care under pressure: a realist review of interventions to tackle doctors’ mental ill-health and its impacts on the clinical workforce and patient care’ - NIHR Health Services & Delivery Research (HSDR) Award 16/53/12 (£201,827) (Co-Chief Investigator)

2017-2018 Turner, A., Pearson, M., Baxter, S., Bunn, F., Hanratty, B., Sheaff, R. & Wilson, P. (2017) ‘New Models of Care - Enhanced dissemination of findings from five NIHR HSDR-funded reviews’ - NIHR Health Services & Delivery Research (HSDR) (£27,224) (Co-investigator)

2016-2017 Sheaff, R., Pearson, M., Lloyd, H., & Byng, R. (2016) ‘From programme theory to logic models for Multi-specialty Community Providers: A realist evidence synthesis’ - NIHR Health Services & Delivery Research (HSDR) Award 15/77/34 (£168,170) (Co-Chief Investigator)

2016-2021 Ismail, K., MacArthur, C., Bick, D. Johnston, T., Roberts, T., Oborn, E., Pearson, M., Tincello, D., Davenport, C., Daniels, J., Dean, S., Hay-Smith, J., Hemming, K., Kidd-Chadwick, J., Bridges, N., & Coleman, T. (2015) ‘Antenatal Prophylactic Pelvic Floor Exercises and Localisation (APPEAL) Programme’ - NIHR Programme Grants for Applied Research (£1,893,723 - Exeter components £305,487) (Co-investigator)

2015-2017 Boyd, K., Rappert, B., Farrimond, H., Pearson, M., Lang, I., Ralph, N., Poole, A. & Mellodew, K. (2015) ‘The Exeter Policing, Evidence and Research Translation (ExPERT) Project’ -College of Policing/ Higher Education Funding Council for England (£249,976) (Co-investigator)

2014-2016 Wong, G., Pearson, M., Mattick, K. & Brennan, N. (2014) ‘Interventions to improve antimicrobial prescribing in doctors in training: a realist review’ - NIHR Health Services & Delivery Research (HSDR) Award 13/97/24 (£187,540) (Co-investigator)

2011-2012 Pearson, M., Jones-Hughes, T., Peters, J. & Whear, R. (2011) Australian Agency for International Development (AusAID) Systematic review - ‘Are interventions to reduce the impact of arsenic contamination of groundwater on human health and crop productivity in developing countries effective?’ Award 59617 (£37,236) (Chief Investigator)

2011-2012 Anderson, R., Pearson, M., Pawson, R., & Shepperd, S. (2011) NIHR Service Delivery & Organisation (SDO) ‘The effective and cost-effective use of intermediate, step-down, hospital at home and other forms of community care as an alternative to acute patient care: a realist review’ - Award 10/1012/07 (£101,079) (Co-investigator)

Lead investigator

Project

Funder

Grant

Started

Status

Project

SERENITY: Towards cancer patient empowerment for optimal use of antithrombotic therapy at the end of life

Funder

UKRI UK Research and Innovation

Grant

£198,784.00

Started

1 October 2022

Status

Ongoing

Project

DAMPen-D II: Improving the Detection, Assessment, Management, and Prevention of Delirium in Palliative Care Units: a cluster Randomised-Controlled Trial, Economic Analysis and Process Evaluation

Funder

NIHR National Institute for Health Research

Grant

£2,142,656.00

Started

1 October 2024

Status

Ongoing

Project

North Yorkshire Health Determinants Research Collaboration

Funder

NIHR National Institute for Health Research

Grant

£989,764.00

Started

1 January 2024

Status

Ongoing

Project

APPEAL: Antenatal Prophylactic Pelvic floor Exercises And Localisation Programme

Funder

NIHR National Institute for Health Research

Grant

£11,634.00

Started

27 November 2017

Status

Complete

Project

Care Under Pressure: a realist review of interventions to tackle doctors’ mental ill-health and its impacts on the clinical workforce and patient care.

Funder

NIHR National Institute for Health Research

Grant

£12,415.00

Started

1 November 2018

Status

Complete

Project

Care Under Pressure 3: Optimising the delivery and impacts of interventions to reduce hospital doctors’ mental ill-health in the NHS

Funder

NIHR National Institute for Health Research

Grant

£22,801.00

Started

1 July 2022

Status

Complete

Project

Strategies to address unprofessional behaviours among staff in acute healthcare settings: a realist review

Funder

NIHR National Institute for Health Research

Grant

£8,128.00

Started

1 October 2021

Status

Complete

Project

TRANSFORM: Detecting, preventing, and managing delirium in specialist palliative care units: Co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care

Funder

YCR Yorkshire Cancer Research

Grant

£106,864.00

Started

15 February 2021

Status

Complete

Project

Arts for the Blues: Towards integrating arts-based approaches to tackling depression in healthcare settings in the North West

Funder

AHRC Arts & Humanities Research Council

Grant

£3,680.00

Started

31 January 2022

Status

Complete

Project

Living well with chronic breathlessness: Improving the sustainable use of supported self-management strategies

Funder

NIHR National Institute for Health Research

Grant

£168,478.00

Started

1 March 2023

Status

Complete

Project

Embedding co-creation, research and action: The North Yorkshire County Council-University of Hull HDRC - QR Funds

Funder

University of Hull

Grant

£22,419.00

Started

1 September 2022

Status

Complete

Project

Understanding the Role of 'Peer Tutors' in Post-Diagnostic Support for People with Dementia: A Realist Process Evaluation of the Good Life with Dementia Approach

Funder

NIHR National Institute for Health Research

Grant

£6,796.00

Started

1 January 2023

Status

Complete

Project

HEIF: QR Policy Development Fund project

Funder

University of Hull

Grant

£9,262.00

Started

1 June 2023

Status

Complete

Co-investigator

Project

Funder

Grant

Started

Status

Project

I3: Building Critical Mass, Increasing Scale and Impact for Palliative Care through International Collaboration

Funder

Research England

Grant

£403,507.00

Started

1 August 2019

Status

Ongoing

Project

PrimaryBreathe: programme to develop and test a brief remote primary care intervention for chronic breathlessness

Funder

NIHR National Institute for Health Research

Grant

£171,920.00

Started

1 September 2022

Status

Ongoing

Project

A phase II, randomised feasibility trial of a tailored, home-based exercise programme on disease-free survival among early stage high-risk recurring cancers in Yorkshire

Funder

YCR Yorkshire Cancer Research

Grant

£932,740.00

Started

1 September 2022

Status

Ongoing

Project

Supporting, enabling and sustaining home care workers to deliver end-of-life care: amultiple-methods community-based case study

Funder

NIHR National Institute for Health Research

Grant

£596,722.00

Started

1 October 2022

Status

Ongoing

Project

NIHR Policy Research Unit (PRU) for Palliative and End of Life Care

Funder

NIHR National Institute for Health Research

Grant

£770,949.00

Started

1 January 2024

Status

Ongoing

Project

BREEZE 2: A randomised controlled trial of a complex intervention to manage breathlessness in pulmonary fibrosis

Funder

NIHR National Institute for Health Research

Grant

£397,551.00

Started

1 April 2024

Status

Ongoing

Project

Understanding barriers and facilitators to implementing physical activity interventions for patients receiving immune checkpoint inhibitor therapy: A qualitative study

Funder

Cancer Prevention and Management-ISBNPA

Grant

£1,015.00

Started

1 November 2023

Status

Ongoing

Project

MABEL: A Parallel Group, Double-blind, Randomised Placebo-controlled Trial Comparing The Efficacy And Cost effectiveness

Funder

NIHR National Institute for Health Research

Grant

£731,726.00

Started

1 March 2019

Status

Complete

Project

Adapting a smartphone-based rehabilitation programme for older adults living with and beyond cancer: an intervention development study

Funder

NIHR National Institute for Health Research

Grant

£135,659.00

Started

1 April 2022

Status

Complete

Project

TRANSFORM: Improving shared decision-making in malignant bowel obstruction: An exploration of context-specific treatment pathways and experiences to inform intervention development for person-centred care

Funder

YCR Yorkshire Cancer Research

Grant

£210,701.00

Started

1 September 2021

Status

Complete

Project

BREATHE-INDIA: BREATHlEssness in INDIA - Development of a breathlessness beliefs and behaviour education intervention for use in the community-setting

Funder

MRC Medical Research Council

Grant

£110,912.00

Started

1 October 2022

Status

Complete

Postgraduate supervision

I welcome enquiries about Master’s or Doctoral research degrees in the following areas:

•Developing and evaluating palliative & chronic care interventions and implementation strategies, particularly in relation to symptom management, outcome measures and models of care

•Methodological development of theory-driven methods (in particular, realist research) for the evaluation of palliative & chronic care interventions

•The use of social science concepts (such as boundary objects) to inform implementation research and practice

Awarded postgraduate research students:

PhD, Jordan Curry: Acceptability, feasibility, and effectiveness of online supportive care interventions for lung cancer survivors (Funded by Yorkshire Cancer Research TRANSFORM programme, 2024)

Master’s by Thesis, Alessandro Recchioni: How can digitisation improve the efficiency of palliative healthcare delivery and the quality of patient experience? (2023)

PhD (Exeter) Rebecca Hardwick: Third sector healthcare organisations and knowledge mobilisation: what works for whom in what circumstances and why? (2018)

PhD (Exeter) Thandiwe Hara-Msulira: Sustaining implementation: Understanding the sustainability of community-based public health programmes (2018)

PhD (Exeter) Harriet Hunt: Optimising cognitive assessment in primary care to support a more effective route to dementia diagnosis (2018)

Current postgraduate research students:

PhD, Laura Jenkinson: No One Talks About Death and Dying - Developing and Evaluating a Serious Game to Facilitate Conversations Around Death and Explore Beliefs Among Nonreligious Individuals (2023-2026)

PhD, Kate Binnie: Body-Mind approaches for living better with chronic breathlessness. (Funded by Research England International Investment Initiative (I3)) (2021-2025)

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