Summary
Dr Leonid Nikitenko is an endothelial cell and cancer biologist. His basic and clinical laboratory research is interdisciplinary (linking biology, medicine and computer science) and focused on studying the role of human endothelial cells in chronic diseases (including cancer, idiopathic pulmonary fibrosis, cardiovascular disease and lymphoedema) and multimorbidity, and on early detection and diagnosis of cancer by using platform technologies (www.endothelial-cell.com).
Alumni from Dr Nikitenko's laboratory and his former tutees at the University of Hull are next generation biomedical scientists who now continue their careers at the Universities of Oxford, Warwick, Manchester and London or in hospitals, the pharmaceutical industry and biotech companies nationwide and abroad.
Google Scholar
https://scholar.google.co.uk/citations?user=ox6Zhu0AAAAJ&hl=en
ResearchGate
https://www.researchgate.net/profile/Leonid_Nikitenko
ResearcherID
https://publons.com/researcher/2621993/leonid-l-nikitenko
Webpage:
http://www.endothelial-cell.com
MSc
Level 7
Research Project and Dissertation
Research Skills in Oncology and Biomedical Science
Current Topics in Biomedical Science
BSc
Level 6
Cancer Biology (module coordinator)
Research Project and Dissertation (40 credit)
Cellular Pathology
Reviews of Biochemistry
Level 5
Biological Basis of Disease
Professional and Research Skills for Biomedical Sciences and Human Biology
Level 4
Cell Structure and Function (module coordinator)
Skills for Biomedical Sciences and Human Biology
Journal Article
Quantitative proteomics reveals CLR interactome in primary human cells
Manolis, D., Hasan, S., Maraveyas, A., O'Brien, D. P., Kessler, B. M., Kramer, H., & Nikitenko, L. L. (2024). Quantitative proteomics reveals CLR interactome in primary human cells. Journal of Biological Chemistry, 300(6), Article 107399. https://doi.org/10.1016/j.jbc.2024.107399
Calcitonin gene-related peptide and intermedin induce phosphorylation of p44/42 MAPK in primary human lymphatic endothelial cells in vitro
Hasan, S. R., Manolis, D., Stephenson, E., Ryskiewicz-Sokalska, O. A., Maraveyas, A., & Nikitenko, L. L. (2024). Calcitonin gene-related peptide and intermedin induce phosphorylation of p44/42 MAPK in primary human lymphatic endothelial cells in vitro. Cellular Signalling, 121, Article 111261. https://doi.org/10.1016/j.cellsig.2024.111261
Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells
Morfitt, M. A., Greenman, J., Maraveyas, A., Harris, A. L., & Nikitenko, L. L. (2023). Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells. Cancer Research, 83(16_Supplement), A020-A020. https://doi.org/10.1158/1538-7445.kidney23-a020
Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer.
Nikitenko, L. L., Manolis, D., O'Brien, D. P., Adekeye, A., Kessler, B. M., Collins, C., …Maraveyas, A. (2023). Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer. Pancreatology, 23(4), e7-e8. https://doi.org/10.1016/j.pan.2023.04.025
Lead investigator
Project
Funder
Grant
Started
Status
Project
Consumables for PhD project Study of Tumour Regulatory Molecules as Markers of Malignancy in Pancreatic Cystic Lesions (TEM-PAC)
Funder
Hull University Teaching Hospitals NHS Trust
Grant
£22,980.00
Started
1 February 2021
Status
Ongoing
Project
EARLY DIAPAC: EARLY DIAgnosis of PAncreatic Cancer by combined proteomics and genomics testing of pancreatic cyst fluid.
Funder
CRUK Cancer Research UK
Grant
£72,818.00
Started
1 December 2022
Status
Ongoing
Project
TEM-PAC 2: Study of Tumour Regulatory Molecules as Markers of Malignancy in Pancreatic Cystic Lesions - Nikitenko
Funder
Hull University Teaching Hospitals NHS Trust
Grant
£135,070.00
Started
1 January 2024
Status
Ongoing
Project
ACF 2023-2026
Funder
NIHR National Institute for Health Research
Grant
£85,576.00
Started
1 September 2023
Status
Ongoing
Project
Fully humanised model of ageing endothelium to study ageing-associated lung diseases:
Funder
Animal Free Research UK
Grant
£24,606.00
Started
1 April 2024
Status
Ongoing
Project
EARLY DIAPAC: EARLY DIAgnosis of PAncreatic Cancer by combined proteomics and genomics testing of pancreatic cyst fluid.
Funder
Cancer Research Technology Ltd
Grant
£38,721.00
Started
1 November 2023
Status
Ongoing
Project
Biochemical Society Summer Vacation Studentship
Funder
Biochemical Society
Grant
£2,402.00
Started
1 June 2024
Status
Ongoing
Project
Dissecting the role of neuropeptide CGRP in human lymphatic endothelial cells
Funder
Wellcome Trust
Grant
£2,768.00
Started
10 June 2019
Status
Complete
Project
The characterisation of G-protein coupled receptor CLR in human endothelial cells
Funder
Biochemical Society
Grant
£1,600.00
Started
10 June 2019
Status
Complete
Project
Development and publication of the booklet for the pulmonary fibrosis (disease with a degree of similarity to coronavirus disease).
Funder
Pulmonary Fibrosis Trust
Grant
£322.00
Started
1 November 2020
Status
Complete
Project
Molecular pathways of pancreatic cancer carcinogenesis from pancreatic cystic neoplasms to adenocarcinoma
Funder
NIHR National Institute for Health Research
Grant
£0.00
Started
1 September 2020
Status
Complete
Project
Updating (Reviewing and Printing) the Patient's Guide to Pulmonary Fibrosis.
Funder
Pulmonary Fibrosis Trust
Grant
£401.00
Started
1 November 2022
Status
Complete
Project
Quantitative proteomic analysis of pancreatic cyst fluid for early detection of cancer using University of Hull HPC Viper
Funder
Hull University Teaching Hospitals NHS Trust
Grant
£6,000.00
Started
1 April 2022
Status
Complete
Project
Fully humanized model to study the role of endothelial cells in ageing human lung
Funder
Animal Free Research UK
Grant
£3,560.00
Started
6 June 2022
Status
Complete
Project
Study of the lung endothelium in idiopathic pulmonary fibrosis
Funder
University of Hull
Grant
£35,465.00
Started
1 September 2020
Status
Complete
Project
Development of fully humanised animal free models to study the role of endothelial cells in chronic diseases.
Funder
Animal Free Research UK
Grant
£1,932.00
Started
2 July 2018
Status
Complete
Co-investigator
Project
Funder
Grant
Started
Status
Project
TEM-PAC 2: Study of Tumour Regulatory Molecules as Markers of Malignancy in Pancreatic Cystic Lesions - Ettelaie
Funder
Hull University Teaching Hospitals NHS Trust
Grant
£119,149.00
Started
1 January 2024
Status
Ongoing
Project
TEM-PAC 2: Study of Tumour Regulatory Molecules as Markers of Malignancy in Pancreatic Cystic Lesions - Maraveyas
Funder
Hull University Teaching Hospitals NHS Trust
Grant
£89,343.00
Started
1 September 2024
Status
Ongoing
Project
Differentiating the malignant potential of pancreatic cysts
Funder
Hull University Teaching Hospitals NHS Trust
Grant
£293,225.00
Started
1 October 2017
Status
Complete
Postgraduate supervision
Applications from prospective PhD or Masters by Thesis (Research) students wishing to join Dr Nikitenko's research group and thriving postgraduate community at the Centre for Biomedicine at Hull-York Medical School are welcome at any time.
In particular, Dr Nikitenko invites expression of interest and applications in the following areas of research.
- Novel molecular mechanisms regulating endothelial cells properties and function in health and chronic diseases.
- G-protein coupled receptors as targets for imaging and therapy in cardiovascular disease, cancer, lymphoedema and lung disease.
- Platform science approaches (next generation sequencing, label-free quantitative proteomics, high content imaging and bioinformatics) to study endothelial and cancer cell biology.
- Three-dimensional models and gene editing to study the role for endothelial cells in tumour microenvironment in cancer progression.
- Proteomics of lymphatic endothelial cells.
- Cancer progression and resistance to targeted therapies .
- Early diagnosis and detection of cancer.