Dr Leonid Nikitenko

Dr Leonid Nikitenko

Lecturer in Biomedical Sciences

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Qualifications

  • PhD / DPhil
  • PhD / DPhil

Summary

Dr Leonid Nikitenko is an endothelial cell and cancer biologist. His basic and clinical laboratory research is interdisciplinary (linking biology, medicine and computer science) and focused on studying the role of human endothelial cells in chronic diseases (including cancer, idiopathic pulmonary fibrosis, cardiovascular disease and lymphoedema) and multimorbidity, and on early detection and diagnosis of cancer by using platform technologies (www.endothelial-cell.com).

Alumni from Dr Nikitenko's laboratory and his former tutees at the University of Hull are next generation biomedical scientists who now continue their careers at the Universities of Oxford, Warwick, Manchester and London or in hospitals, the pharmaceutical industry and biotech companies nationwide and abroad.

Google Scholar

https://scholar.google.co.uk/citations?user=ox6Zhu0AAAAJ&hl=en

ResearchGate

https://www.researchgate.net/profile/Leonid_Nikitenko

ResearcherID

https://publons.com/researcher/2621993/leonid-l-nikitenko

Webpage:

http://www.endothelial-cell.com

MSc

Level 7

Research Project and Dissertation

Research Skills in Oncology and Biomedical Science

Current Topics in Biomedical Science

BSc

Level 6

Cancer Biology (module coordinator)

Research Project and Dissertation (40 credit)

Cellular Pathology

Reviews of Biochemistry

Level 5

Biological Basis of Disease

Professional and Research Skills for Biomedical Sciences and Human Biology

Level 4

Cell Structure and Function (module coordinator)

Skills for Biomedical Sciences and Human Biology

Recent outputs

View more outputs

Journal Article

Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells

Morfitt, M. A., Greenman, J., Maraveyas, A., Harris, A. L., & Nikitenko, L. L. (2023). Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells. Cancer Research, 83(16_Supplement), A020-A020. https://doi.org/10.1158/1538-7445.kidney23-a020

Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment

Morfitt, M. A., Greenman, J., Maraveyas, A., & Nikitenko, L. L. (2023). Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment. Cancer Research, 83(16_Supplement), B001-B001. https://doi.org/10.1158/1538-7445.kidney23-b001

Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer.

Nikitenko, L. L., Manolis, D., O'Brien, D. P., Adekeye, A., Kessler, B. M., Collins, C., …Maraveyas, A. (2023). Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer. Pancreatology, 23(4), e7-e8. https://doi.org/10.1016/j.pan.2023.04.025

Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer

Adekeye, A., Haque, F., Ettelaie, C., Nikitenko, L., & Maraveyas, A. (2023). Abstract 224: Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection and diagnosis of pancreatic cancer. Cancer Research, 83(7_Supplement), 224-224. https://doi.org/10.1158/1538-7445.am2023-224

Working Paper

Novel protein interaction network of human calcitonin receptor-like receptor revealed by label-free quantitative proteomics

Manolis, D., Hasan, S., Ettelaie, C., Maraveyas, A., O'Brien, D., Kessler, B., …Nikitenko, L. Novel protein interaction network of human calcitonin receptor-like receptor revealed by label-free quantitative proteomics

Lead investigator

Project

Funder

Grant

Started

Status

Project

Consumables for PhD project Study of Tumour Regulatory Molecules as Markers of Malignancy in Pancreatic Cystic Lesions (TEM-PAC)

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£22,980.00

Started

1 February 2021

Status

Ongoing

Project

EARLY DIAPAC: EARLY DIAgnosis of PAncreatic Cancer by combined proteomics and genomics testing of pancreatic cyst fluid.

Funder

CRUK Cancer Research UK

Grant

£72,818.00

Started

1 December 2022

Status

Ongoing

Project

ACF 2023-2026

Funder

NIHR National Institute for Health Research

Grant

£85,576.00

Started

1 September 2023

Status

Ongoing

Project

EARLY DIAPAC: EARLY DIAgnosis of PAncreatic Cancer by combined proteomics and genomics testing of pancreatic cyst fluid.

Funder

Cancer Research Technology Ltd

Grant

£33,551.00

Started

1 November 2023

Status

Ongoing

Project

Dissecting the role of neuropeptide CGRP in human lymphatic endothelial cells

Funder

Wellcome Trust

Grant

£2,768.00

Started

10 June 2019

Status

Complete

Project

The characterisation of G-protein coupled receptor CLR in human endothelial cells

Funder

Biochemical Society

Grant

£1,600.00

Started

10 June 2019

Status

Complete

Project

Development and publication of the booklet for the pulmonary fibrosis (disease with a degree of similarity to coronavirus disease).

Funder

Pulmonary Fibrosis Trust

Grant

£322.00

Started

1 November 2020

Status

Complete

Project

Molecular pathways of pancreatic cancer carcinogenesis from pancreatic cystic neoplasms to adenocarcinoma

Funder

NIHR National Institute for Health Research

Grant

£0.00

Started

1 September 2020

Status

Complete

Project

Updating (Reviewing and Printing) the Patient's Guide to Pulmonary Fibrosis.

Funder

Pulmonary Fibrosis Trust

Grant

£401.00

Started

1 November 2022

Status

Complete

Project

Quantitative proteomic analysis of pancreatic cyst fluid for early detection of cancer using University of Hull HPC Viper

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£6,000.00

Started

1 April 2022

Status

Complete

Project

Fully humanized model to study the role of endothelial cells in ageing human lung

Funder

Animal Free Research UK

Grant

£3,560.00

Started

6 June 2022

Status

Complete

Project

Study of the lung endothelium in idiopathic pulmonary fibrosis

Funder

00 University of Hull

Grant

£35,465.00

Started

1 September 2020

Status

Complete

Project

TEM-PAC 2: Study of Tumour Regulatory Molecules as Markers of Malignancy in Pancreatic Cystic Lesions - Nikitenko

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£65,651.00

Started

1 January 2023

Status

Complete

Project

Development of fully humanised animal free models to study the role of endothelial cells in chronic diseases.

Funder

Animal Free Research UK

Grant

£1,932.00

Started

2 July 2018

Status

Complete

Co-investigator

Project

Funder

Grant

Started

Status

Project

Differentiating the malignant potential of pancreatic cysts

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£293,225.00

Started

1 October 2017

Status

Complete

Project

TEM-PAC 2: Study of Tumour Regulatory Molecules as Markers of Malignancy in Pancreatic Cystic Lesions - Ettelaie

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£57,691.00

Started

1 January 2023

Status

Complete

Project

TEM-PAC 2: Study of Tumour Regulatory Molecules as Markers of Malignancy in Pancreatic Cystic Lesions - Maraveyas

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£89,343.00

Started

1 January 2023

Status

Complete

Postgraduate supervision

Applications from prospective PhD or Masters by Thesis (Research) students wishing to join Dr Nikitenko's research group and thriving postgraduate community at the Centre for Biomedicine at Hull-York Medical School are welcome at any time.

In particular, Dr Nikitenko invites expression of interest and applications in the following areas of research.

- Novel molecular mechanisms regulating endothelial cells properties and function in health and chronic diseases.

- G-protein coupled receptors as targets for imaging and therapy in cardiovascular disease, cancer, lymphoedema and lung disease.

- Platform science approaches (next generation sequencing, label-free quantitative proteomics, high content imaging and bioinformatics) to study endothelial and cancer cell biology.

- Three-dimensional models and gene editing to study the role for endothelial cells in tumour microenvironment in cancer progression.

- Proteomics of lymphatic endothelial cells.

- Cancer progression and resistance to targeted therapies .

- Early diagnosis and detection of cancer.

Honorary position

Member, Linacre College, Oxford

2002

Membership/Fellowship of professional body

Senior Fellow, Higher Education Academy

2019

Fellow, Royal Society of Biology

2016

Fellow, Institute of Biomedical Science

2016

Member, Lymphatic Education and Research Network (LERN)

2016

Active Member, American Association for Cancer Research

2013

Full Member, Biochemical Society

2003

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