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Dr Katie Wraith

Senior Laboratory Research Scientist

+44 (0)1482 464732 | K.Wraith@hull.ac.uk

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Related groups

  • Centre for Biomedicine

Qualifications

  • PhD / DPhil (Hull York Medical School)

Summary

Katie completed her PhD in Medical Sciences at the Hull York Medical School in 2013 investigating the influence of oxidised low-density lipoproteins on platelet function and signalling in the laboratory of Professor Khalid Naseem. Following on from this, she worked as a Post-Doctoral Research Assistant in platelet biology research in Professor Naseem’s laboratory for four years. In 2022 she began work as a Senior Laboratory Research Scientist within the cardiovascular research laboratory of Professor Tim Palmer at the Hull York Medical School and was appointed to Lecturer in Cardiovascular Biology in 2024.

Delivery of Phase I SSIP module on Haemostasis and Thrombosis in Cardiovascular Diseases on the MB BS Medicine Programme.

Recent outputs

View more outputs

Journal Article

Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets

Aburima, A., Berger, M., Spurgeon, B. E., Webb, B. A., Wraith, K. S., Febbraio, M., …Naseem, K. M. (2021). Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets. Blood, 137(5), 678-689. https://doi.org/10.1182/blood.2020005382

Ahmed Aburima

Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin-; the role of phosphodiesterase 3A.

Berger, M., Raslan, Z., Aburima, A., Magwenzi, S., Wraith, K. S., Spurgeon, B. E., …Naseem, K. M. (2020). Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin-; the role of phosphodiesterase 3A. Haematologica, 105(3), 808-819. https://doi.org/10.3324/haematol.2018.213348

Ahmed Aburima

Dyslipidemia-associated atherogenic oxidized lipids induce platelet hyperactivity through phospholipase Cγ2-dependent reactive oxygen species generation

Berger, M., Wraith, K., Woodward, C., Aburima, A., Raslan, Z., Hindle, M. S., …Naseem, K. M. (2019). Dyslipidemia-associated atherogenic oxidized lipids induce platelet hyperactivity through phospholipase Cγ2-dependent reactive oxygen species generation. Platelets, 30(4), 467-472. https://doi.org/10.1080/09537104.2018.1466386

Ahmed Aburima

Platelet function following induced hypoglycaemia in type 2 diabetes

Kahal, H., Aburima, A., Spurgeon, B., Wraith, K. S., Rigby, A. S., Sathyapalan, T., …Atkin, S. L. (2018). Platelet function following induced hypoglycaemia in type 2 diabetes. Diabetes & metabolism, 44(5), 431-436. https://doi.org/10.1016/j.diabet.2018.04.004

Alan Rigby Thozhukat Sathyapalan Ahmed Aburima

Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade

Magwenzi, S., Woodward, C., Wraith, K. S., Aburima, A., Raslan, Z., Jones, H., …Naseem, K. M. (2015). Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade. Blood, 125(17), 2693-2703. https://doi.org/10.1182/blood-2014-05-574491

Ahmed Aburima

Research interests

Katie’s research focuses on how platelet and coagulation function are altered in cardiovascular diseases. In particular, her laboratory is interested in how oxidised low-density lipoproteins (oxLDL) or “bad cholesterol” can influence the activation of platelets and the coagulation pathway to result in a prothrombotic phenotype present in many cardiovascular diseases and specifically in atherosclerosis. Her research examines how oxLDL can enhance platelet activation and pro-coagulant responses as well as fibrin formation resulting in larger thrombi that are harder to break down.

Postgraduate supervision

Enquiries from prospective students who wish to study for a PhD in the area of platelet and coagulation biology are welcome.

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