Summary
Programme director for Applied Exercise Science for Health/ Research Ethics Committee, Physiology/ Health and Safety Officer
Dr James Hobkirk joined the Department of Sport, Health and Exercise Science in April 2015 as a lecturer in physiology.
He received his PhD, entitled Hypertriglyceridaemia, small dense low-density lipoproteins and cardio-metabolic risk stratification in paediatric obesity, in 2011.
James is scientific director and an honorary scientist in the Department of Cardiothoracic Surgery at the Hull and East Yorkshire NHS Trust.
He collaborates with international academics and clinicians, and is a member of the Royal Society of Medicine, an expert reviewer for the Health Research Authority and sits on the editorial board of a clinical journal.
Journal Article
Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents
Barbian, C. D., Reuter, C. P., Renner, J. D. P., da Silva, P. T., Klinger, E. I., Hobkirk, J. P., …Burgos, M. S. (2020). Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents. Journal of Pediatric Genetics, 9(1), 019-026. https://doi.org/10.1055/s-0039-3399511
The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome
Sathyapalan, T., Hobkirk, J. P., Javed, Z., Carroll, S., Coady, A. M., Pemberton, P., …Atkin, S. L. (2019). The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome. Frontiers in endocrinology, 10(JUN), https://doi.org/10.3389/fendo.2019.00394
Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice
Carroll, S., Hobkirk, J., Browning, M. J., Janus, J., Kheder, R., Saeed, Z., & Stover, C. (2017). Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice. Immunity, Inflammation and Disease, 5(2), 151-154. https://doi.org/10.1002/iid3.154
Exploring quality of life in patients with and without heart failure
Zhang, J., Hobkirk, J., Carroll, S., Pellicori, P., Clark, A. L., & Cleland, J. G. (2016). Exploring quality of life in patients with and without heart failure. International journal of cardiology, 202, 676-684. https://doi.org/10.1016/j.ijcard.2015.09.076
Postgraduate supervision
James currently co-supervises a number of postgraduate students within the remit of pathophysiology of human disease, metabolic dysregulation and organ specific lipotoxicity. He is particularly interested in the mechanisms and treatment of metabolic dysregulation in the blood and at the tissue and cellular level via nutritional, exercise and pharmaceutical therapies.
Completed PhDs
- Mr Ramiar Kheder, Nutritional strategies to reduce lipogenesis, inflammation and fibrosis in mouse hepatic tissue, isolated macrophages and Hep G2 cells (PhD, with Dr C Stover, University of Leicester)
Current PhD supervisions
- Mr Yama Haqzad, Lipogenic and oxidative gene profiles controlling myocardial energy metabolism (MD)
- Mr Zaheer Tahir, Modulating cardiac energy metabolism in ex vivo right atria and human cardiomyocytes with dicholoracetatev (MD)