Dr Chao Huang

Dr Chao Huang

Reader in Statistics

Faculty and Department

  • Faculty of Health Sciences
  • Hull York Medical School

Qualifications

  • PhD / DPhil (University of Manchester)

Summary

Dr. Chao Huang obtained his PhD in Statistics from the University of Manchester in 2010 and then he worked as a Postdoctoral Research Associate in medical statistics during the following year. From 2012, he started his role as a Trial Statistician at the South East Wales Trial Unit, Centre for Trials Research, Cardiff University. From October 2017, he joined the Hull York Medical School, University of Hull.

Within Hull York Medical School, Dr. Chao Huang undertakes teachings in statistics-related modules, covering the Gateway (Medical Scholarship Module), MBBS (Scholarship and Special Interest Programme) and PGT programmes (Bench to Bedside II clinical trials module in MSc in Pharmacology and Drug Development). He also provides teaching and consultancy services in statistics and evidence based medicine to NHS professionals from Hull University Teaching Hospital NHS Trust. He sits in the HYMS’s academic case committee (ACC) and Student Fitness to Practise Committee (SFTPC).

Recent outputs

View more outputs

Journal Article

Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial

Waldron, C. A., Pallmann, P., Schoenbuchner, S., Harris, D., Brookes-Howell, L., Mateus, C., Bernatoniene, J., Cathie, K., Faust, S. N., Hinds, L., Hood, K., Huang, C., Jones, S., Kotecha, S., Nabwera, H. M., Patel, S., Paulus, S. C., Powell, C. V. E., Preston, J., Xiang, H., …on behalf of the BATCH Trial Team. (2025). Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial. The Lancet Child & Adolescent Health, 9(2), 121-130. https://doi.org/10.1016/S2352-4642%2824%2900306-7

The relationship between muscle mass changes and protein or energy intake in critically ill children: A systematic review and meta-analysis

Stacey, L. J., Valla, F. V., Huang, C., Comfort, P., Chaparro, C. J., Latten, L., & Tume, L. N. (in press). The relationship between muscle mass changes and protein or energy intake in critically ill children: A systematic review and meta-analysis. Journal of Parenteral and Enteral Nutrition, https://doi.org/10.1002/jpen.2715

Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol

Prosser, J., Staniland, T., Harwood, A., Ravindhran, B., McGregor, G., Huang, C., Twiddy, M., Nicholls, A., Ingle, L., Long, J., Chetter, I., & Pymer, S. (2024). Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol. Journal of Vascular Societies Great Britain and Ireland, 3(3), 155-159. https://doi.org/10.54522/jvsgbi.2024.103

Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care

Jackson, G. P., Jackson, C., Boland, J. W., Featherstone, I., Huang, C., Ogden, M., Sartain, K., Siddiqi, N., Twiddy, M., Pearson, M., & Johnson, M. J. (2024). Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care. Palliative medicine, 38(4), 447-456. https://doi.org/10.1177/02692163241236325

Association between protein intake and muscle wasting in critically ill children: a prospective cohort study

Tume, L. N., Simons, C., Latten, L., Huang, C., Comfort, P., Compton, V., Wagh, A., Veale, A., & Valla, F. V. (in press). Association between protein intake and muscle wasting in critically ill children: a prospective cohort study. Journal of Parenteral and Enteral Nutrition, https://doi.org/10.1002/jpen.2627

Research interests

As a statistical methodologist, Dr. Chao Huang’s research interests lie in the development of methodological and applied statistical research in various fields, with a specific focus on health-related sciences. This includes longitudinal data analysis, addressing missing data issues and informative observations, survival analysis, utilising joint modelling approach, conducting variable selection, performing simulation-based sample size calculations, and determining the adjusted anchor-based minimal clinically important difference.

As a statistician in medical school, Dr. Chao Huang specialises in quantitative study design and analysis in health-related research. Dr. Chao Huang establishes and expands research collaborations within HYMS and across faculties. He works with health professionals from the NHS, as well as trialists and researchers from external institutions through national and EU-funded research projects. In the capacity of principal investigator, Dr. Chao Huang initiates and leads studies for international research projects.

Lead investigator

Project

Funder

Grant

Started

Status

Project

Mortality Risk Prediction of ICU Patients with Sepsis Considering Dynamic Time Series Characteristics under Uncertainty

Funder

The Royal Society

Grant

£11,989.00

Started

31 March 2023

Status

Ongoing

Project

Prevalence of cirrhosis and its related complications amongst patients with hereditary haemochromatosis in England

Funder

York and Scarborough Teaching Hospitals NHS Foundation Trust

Grant

£2,848.00

Started

1 April 2023

Status

Ongoing

Project

BATCH: Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection

Funder

NIHR National Institute for Health Research

Grant

£6,778.00

Started

1 September 2017

Status

Complete

Project

PUMA: Paediatric early warning system (PEWS): Utilisation and Mortality Avoidance. A prospective, mixed methods, before and after study identifying the evidence base for the core components of an effective PEWS and the development of an implementation package for implementation and use in the UK

Funder

NIHR National Institute for Health Research

Grant

£2,022.00

Started

1 October 2017

Status

Complete

Project

The TRANSPIRE Study: A prospective observational study to explore the relationship between nuTRition, protein intake ANd muScle mass loss during and after Pediatric Intensive caRE

Funder

NIHR National Institute for Health Research

Grant

£10,676.00

Started

1 August 2021

Status

Complete

Co-investigator

Project

Funder

Grant

Started

Status

Project

A phase II, randomised feasibility trial of a tailored, home-based exercise programme on disease-free survival among early stage high-risk recurring cancers in Yorkshire

Funder

YCR Yorkshire Cancer Research

Grant

£932,740.00

Started

1 September 2022

Status

Ongoing

Project

Evaluating the effectiveness and acceptability of free door to door transport to increase the uptake of breast screening appointments in Yorkshire: A cluster randomised GP pilot trial

Funder

YCR Yorkshire Cancer Research

Grant

£293,513.00

Started

1 June 2023

Status

Ongoing

Project

REMEDI4ALL BUILDING A SUSTAINABLE EUROPEAN INNOVATION PLATFORM TO ENHANCE THE REPURPOSING OF MEDICINES FOR ALL

Funder

Innovate UK

Grant

£922,056.00

Started

1 September 2022

Status

Ongoing

Project

BREEZE 2: A randomised controlled trial of a complex intervention to manage breathlessness in pulmonary fibrosis

Funder

NIHR National Institute for Health Research

Grant

£397,551.00

Started

1 April 2024

Status

Ongoing

Project

DAMPen-D II: Improving the Detection, Assessment, Management, and Prevention of Delirium in Palliative Care Units: a cluster Randomised-Controlled Trial, Economic Analysis and Process Evaluation

Funder

NIHR National Institute for Health Research

Grant

£2,142,656.00

Started

1 October 2024

Status

Ongoing

Project

HIKE: Development of a commercial urine test for the earlier detection of endometriosis

Funder

MRC Medical Research Council

Grant

£54,915.00

Started

1 July 2023

Status

Ongoing

Project

Endometriosis and bleeding disorders: detection of endometriosis and identification of new treatment strategies

Funder

The Haemophilia Society

Grant

£4,000.00

Started

1 September 2024

Status

Ongoing

Project

Endoscopic vein harvesting - Research Support Funding

Funder

Hull University Teaching Hospitals NHS Trust

Grant

£9,431.00

Started

1 August 2022

Status

Complete

Project

Pre-Operative Oncotype DX testing: A decision impact study (PRE-DX study)

Funder

Exact Sciences

Grant

£365,121.00

Started

1 July 2022

Status

Complete

Project

Adapting a smartphone-based rehabilitation programme for older adults living with and beyond cancer: an intervention development study

Funder

NIHR National Institute for Health Research

Grant

£135,659.00

Started

1 April 2022

Status

Complete

Project

The Cognitive Daisy (COG-D) for improving care for residents with dementia in care homes: A feasibility RCT

Funder

NIHR National Institute for Health Research

Grant

£39,856.00

Started

1 April 2022

Status

Complete

Project

NIHR Pre-doctoral Fellowship - Laura Hermann

Funder

NIHR National Institute for Health Research

Grant

£106,734.00

Started

1 September 2021

Status

Complete

Project

Systematic review & network meta-analysis of randomised controlled trials comparing antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease.

Funder

NIHR National Institute for Health Research

Grant

£31,580.00

Started

1 November 2022

Status

Complete

Postgraduate supervision

You are very welcome to contact me for potential PhD opportunities, if you have statistics related background and are interested in research on statistical methodology or medical statistics.

Current PGR students

2024-: PhD student- Karen-Marie Cowap. Suicide and Addiction: improving care pathways for people presenting to secondary care services. (co-supervisor)

2024- : PhD student- Natasha Lund. Resilience within the context of newly qualified nurses (co-supervisor)

2023- : MD student- Prabhsimran Singh. Prevalence of cirrhosis and its related complications amongst patients with Hereditary hemochromatosis in England (principal supervisor)

Previous PGR students:

2019 -2024: PhD student-Saphsa Codling. Elucidating the relationships between physical activity, physical and psychological health status (including mood, stress) and alcohol misuse in women (co-supervisor).

2021- 2023: NIHR Pre-doctoral Fellowship - Laura Hermann (research-supervisor)

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