Journal Article
Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial
Crooks, M. G., Wright, C., Hart, S., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Simpson, A., Huang, C., Sykes, D. L., & Johnson, M. (2025). Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial. BMJ Open Respiratory Research, 12(1), Article e002327. https://doi.org/10.1136/bmjresp-2024-002327
Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial
Waldron, C. A., Pallmann, P., Schoenbuchner, S., Harris, D., Brookes-Howell, L., Mateus, C., Bernatoniene, J., Cathie, K., Faust, S. N., Hinds, L., Hood, K., Huang, C., Jones, S., Kotecha, S., Nabwera, H. M., Patel, S., Paulus, S. C., Powell, C. V. E., Preston, J., Xiang, H., …on behalf of the BATCH Trial Team. (2025). Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial. The Lancet Child & Adolescent Health, 9(2), 121-130. https://doi.org/10.1016/S2352-4642%2824%2900306-7
The relationship between muscle mass changes and protein or energy intake in critically ill children: A systematic review and meta-analysis
Stacey, L. J., Valla, F. V., Huang, C., Comfort, P., Chaparro, C. J., Latten, L., & Tume, L. N. (in press). The relationship between muscle mass changes and protein or energy intake in critically ill children: A systematic review and meta-analysis. Journal of Parenteral and Enteral Nutrition, https://doi.org/10.1002/jpen.2715
Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol
Prosser, J., Staniland, T., Harwood, A., Ravindhran, B., McGregor, G., Huang, C., Twiddy, M., Nicholls, A., Ingle, L., Long, J., Chetter, I., & Pymer, S. (2024). Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol. Journal of Vascular Societies Great Britain and Ireland, 3(3), 155-159. https://doi.org/10.54522/jvsgbi.2024.103
Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care
Jackson, G. P., Jackson, C., Boland, J. W., Featherstone, I., Huang, C., Ogden, M., Sartain, K., Siddiqi, N., Twiddy, M., Pearson, M., & Johnson, M. J. (2024). Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care. Palliative medicine, 38(4), 447-456. https://doi.org/10.1177/02692163241236325
Research interests
As a statistical methodologist, Dr. Chao Huang’s research interests lie in the development of methodological and applied statistical research in various fields, with a specific focus on health-related sciences. This includes longitudinal data analysis, addressing missing data issues and informative observations, survival analysis, utilising joint modelling approach, conducting variable selection, performing simulation-based sample size calculations, and determining the adjusted anchor-based minimal clinically important difference.
As a statistician in medical school, Dr. Chao Huang specialises in quantitative study design and analysis in health-related research. Dr. Chao Huang establishes and expands research collaborations within HYMS and across faculties. He works with health professionals from the NHS, as well as trialists and researchers from external institutions through national and EU-funded research projects. In the capacity of principal investigator, Dr. Chao Huang initiates and leads studies for international research projects.
Lead investigator
Project
Funder
Grant
Started
Status
Project
Mortality Risk Prediction of ICU Patients with Sepsis Considering Dynamic Time Series Characteristics under Uncertainty
Funder
The Royal Society
Grant
£11,989.00
Started
31 March 2023
Status
Ongoing
Project
Prevalence of cirrhosis and its related complications amongst patients with hereditary haemochromatosis in England
Funder
York and Scarborough Teaching Hospitals NHS Foundation Trust
Grant
£2,848.00
Started
1 April 2023
Status
Ongoing
Project
BATCH: Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection
Funder
NIHR National Institute for Health Research
Grant
£6,778.00
Started
1 September 2017
Status
Complete
Project
PUMA: Paediatric early warning system (PEWS): Utilisation and Mortality Avoidance. A prospective, mixed methods, before and after study identifying the evidence base for the core components of an effective PEWS and the development of an implementation package for implementation and use in the UK
Funder
NIHR National Institute for Health Research
Grant
£2,022.00
Started
1 October 2017
Status
Complete
Project
The TRANSPIRE Study: A prospective observational study to explore the relationship between nuTRition, protein intake ANd muScle mass loss during and after Pediatric Intensive caRE
Funder
NIHR National Institute for Health Research
Grant
£10,676.00
Started
1 August 2021
Status
Complete
Co-investigator
Project
Funder
Grant
Started
Status
Project
A phase II, randomised feasibility trial of a tailored, home-based exercise programme on disease-free survival among early stage high-risk recurring cancers in Yorkshire
Funder
YCR Yorkshire Cancer Research
Grant
£932,740.00
Started
1 September 2022
Status
Ongoing
Project
Evaluating the effectiveness and acceptability of free door to door transport to increase the uptake of breast screening appointments in Yorkshire: A cluster randomised GP pilot trial
Funder
YCR Yorkshire Cancer Research
Grant
£293,513.00
Started
1 June 2023
Status
Ongoing
Project
REMEDI4ALL BUILDING A SUSTAINABLE EUROPEAN INNOVATION PLATFORM TO ENHANCE THE REPURPOSING OF MEDICINES FOR ALL
Funder
Innovate UK
Grant
£922,056.00
Started
1 September 2022
Status
Ongoing
Project
BREEZE 2: A randomised controlled trial of a complex intervention to manage breathlessness in pulmonary fibrosis
Funder
NIHR National Institute for Health Research
Grant
£397,551.00
Started
1 April 2024
Status
Ongoing
Project
DAMPen-D II: Improving the Detection, Assessment, Management, and Prevention of Delirium in Palliative Care Units: a cluster Randomised-Controlled Trial, Economic Analysis and Process Evaluation
Funder
NIHR National Institute for Health Research
Grant
£2,142,656.00
Started
1 October 2024
Status
Ongoing
Project
Endometriosis and bleeding disorders: detection of endometriosis and identification of new treatment strategies
Funder
The Haemophilia Society
Grant
£4,000.00
Started
1 September 2024
Status
Ongoing
Project
HIKE: Development of a non-invasive urine test to detect ovarian cancer
Funder
MRC Medical Research Council
Grant
£14,184.00
Started
11 April 2025
Status
Ongoing
Project
Endoscopic vein harvesting - Research Support Funding
Funder
Hull University Teaching Hospitals NHS Trust
Grant
£9,431.00
Started
1 August 2022
Status
Complete
Project
Pre-Operative Oncotype DX testing: A decision impact study (PRE-DX study)
Funder
Exact Sciences
Grant
£365,121.00
Started
1 July 2022
Status
Complete
Project
Adapting a smartphone-based rehabilitation programme for older adults living with and beyond cancer: an intervention development study
Funder
NIHR National Institute for Health Research
Grant
£135,659.00
Started
1 April 2022
Status
Complete
Project
The Cognitive Daisy (COG-D) for improving care for residents with dementia in care homes: A feasibility RCT
Funder
NIHR National Institute for Health Research
Grant
£39,856.00
Started
1 April 2022
Status
Complete
Project
NIHR Pre-doctoral Fellowship - Laura Hermann
Funder
NIHR National Institute for Health Research
Grant
£106,734.00
Started
1 September 2021
Status
Complete
Project
Systematic review & network meta-analysis of randomised controlled trials comparing antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease.
Funder
NIHR National Institute for Health Research
Grant
£31,580.00
Started
1 November 2022
Status
Complete
Project
HIKE: Development of a commercial urine test for the earlier detection of endometriosis
Funder
MRC Medical Research Council
Grant
£54,915.00
Started
1 July 2023
Status
Complete
Postgraduate supervision
You are very welcome to contact me for potential PhD opportunities, if you have statistics related background and are interested in research on statistical methodology or medical statistics.
Current PGR students
2024-: PhD student- Karen-Marie Cowap. Suicide and Addiction: improving care pathways for people presenting to secondary care services. (co-supervisor)
2024- : PhD student- Natasha Lund. Resilience within the context of newly qualified nurses (co-supervisor)
2023- : MD student- Prabhsimran Singh. Prevalence of cirrhosis and its related complications amongst patients with Hereditary hemochromatosis in England (principal supervisor)
Previous PGR students:
2019 -2024: PhD student-Saphsa Codling. Elucidating the relationships between physical activity, physical and psychological health status (including mood, stress) and alcohol misuse in women (co-supervisor).
2021- 2023: NIHR Pre-doctoral Fellowship - Laura Hermann (research-supervisor)