sandra jones

Dr Sandra Jones

Senior Lecturer in Biomedical Science

Faculty and Department

  • Faculty of Health Sciences
  • School of Life Sciences

Summary

Sandra gained her BSc from the University of Leeds and her PhD from the University of Liverpool. She returned to Leeds for her first doctoral position, where her ongoing research into ageing and the heart began. This developed during her senior doctoral position, funded as principal investigator by the BHF, followed by a Lectureship in Physiology. Sandra was appointed to a Lectureship in Biomedical Science at Hull in 2007. She is also a member of the Centre for Cardiovascular and Metabolic Research at Hull York Medical School. Her research concerns the causes of cardiac dysfunction, particularly in association with ageing. Conferences co-organised - British Society for Cardiovascular Research, Leeds, 2016 - Physiological Society Inaugural H3 symposium, London, 2014 - Northern Cardiac Research Group, Hull, 2011 - British Society for Research on Ageing, Manchester, 2009 Invited speaker - University of Florida, Gainesville, 'Ageing to Arrhythmias: Conundrums of Connections in the Ageing Heart', 2015 - Physiological Society Inaugural H3 Symposium, London, 'Stem Cells and the Heart: Where Do the Future Therapies Lie for Cardiac Regeneration?', 2014

Journal Article

K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

Jones, S. A., Walton, R. D., Morton, M., & Lancaster, M. K. (2019). K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall. Journal of Cardiovascular Electrophysiology, 30, 383-391. https://doi.org/10.1111/jce.13805

K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

Jones, S. A., Walton, R. D., Morton, M., & Lancaster, M. K. (2019). K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall. Journal of Cardiovascular Electrophysiology, 30(3), 383-391. https://doi.org/10.1111/jce.13805

Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium

Jones, S. A., & Lancaster, M. K. (2015). Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium. Mechanisms of ageing and development, 146-148, 72-80. https://doi.org/10.1016/j.mad.2015.05.001

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats

Choisy, S. C., Kim, S., Hancox, J. C., Jones, S. A., & James, A. F. (2015). Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats. Physiological Reports, 3(1), e12274. doi:10.14814/phy2.12274

Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart

Walton, R. D., Jones, S. A., Rostron, K. A., Kayani, A. C., Close, G. L., McArdle, A., & Lancaster, M. K. (2016). Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart. The journals of gerontology. Series A, Biological sciences and medical sciences, 71(8), (1005-1013). doi:10.1093/gerona/glv093. ISSN 1079-5006

Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload

Kim, S., Choisy, S. C., Barman, P., Zhang, H., Hancox, J. C., Jones, S. A., & James, A. F. (2011). Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload. Circulation. Arrhythmia and electrophysiology, 4(5), 761-769. doi:10.1161/CIRCEP.111.964783

Postgraduate supervision

Dr Jones welcomes applicants with experience in mammalian physiology (at degree level) and specific knowledge of the heart. Applicants should understand how ion channels contribute and give rise to the normal action potential of the mammalian heart at a basic degree level, as her research focuses on cardiac dysfunction and how it arises (for example with ageing). The techniques used in the laboratory are proteomic, genomic and functional. At the time of appointment, specific projects will be offered in line with ongoing projects in the group. Completed PhDs - Amy Dawson, Paper Microfluidics for Clinical Diagnostics Using Colorimetric Detection Methods, 2010-14 (as second supervisor) - Dr Fiona Hatch, Age-Associated Changes to Calcium Handling Proteins across the Whole Heart, 2009-13 (as primary supervisor) - Amy Dawson, Age-Dependent Expression and Distribution of Cardiac Progenitor Cells in the Adult Heart, 2009-10 (Research MSc, as primary supervisor) Current PhD supervisions - Stephanie Cooper, Microanalysis ‘On-Chip' of Cardiac Function, 2013- (primary supervisor) - Donatus Onwuli, Sodium Channel Mutations, 2014- (co-supervisor)