sandra jones

Dr Sandra Jones

Senior Lecturer in Biomedical Science

Faculty and Department

  • Faculty of Health Sciences
  • Department of Biomedical Sciences

Summary

Sandra gained her BSc from the University of Leeds and her PhD from the University of Liverpool. She returned to Leeds for her first doctoral position, where her ongoing research into ageing and the heart began. This developed during her senior doctoral position, funded as principal investigator by the BHF, followed by a Lectureship in Physiology. Sandra was appointed to a Lectureship in Biomedical Science at Hull in 2007. She is also a member of the Centre for Cardiovascular and Metabolic Research at Hull York Medical School. Her research concerns the causes of cardiac dysfunction, particularly in association with ageing.

Conferences co-organized; 2016 British Society for Cardiovascular Research at the University of Leeds, 2014 Physiological Society Inaugural H3 symposium London, 2011 Northern Cardiac Research Group, at the University of Hull, 2009 British Society for Research on Ageing, University of Manchester.

Invited speaker; 2015 University of Florida, Gainesville, 'Ageing to Arrhythmias: Conundrums of Connections in the Ageing Heart'.

2014 Physiological Society Inaugural H3 Symposium, London, 'Stem Cells and the Heart: Where Do the Future Therapies Lie for Cardiac Regeneration?

I am a Fellow of The Physiological Society, and additionally the Society representative https://www.physoc.org/.

Undergraduate

Director of MSc in Biomedical Sciences, taught programme.

Module leader - Muscle fitness and failure (level 6)

Module leader - Ageing, Obesity and Health (level 6)

Module leader - Diseases in Biomedicine (level 7)

Academic support tutor to all MSs Biomedical Sciences students, plus students at Level 3,4,5 &6.

Journal Article

K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

Jones, S. A., Walton, R. D., Morton, M., & Lancaster, M. K. (2019). K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall. Journal of Cardiovascular Electrophysiology, 30(3), 383-391. https://doi.org/10.1111/jce.13805

Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium

Jones, S. A., & Lancaster, M. K. (2015). Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium. Mechanisms of ageing and development, 146-148, 72-80. https://doi.org/10.1016/j.mad.2015.05.001

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats

Choisy, S. C., Kim, S., Hancox, J. C., Jones, S. A., & James, A. F. (2015). Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats. Physiological Reports, 3(1), e12274. https://doi.org/10.14814/phy2.12274

Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart

Walton, R. D., Jones, S. A., Rostron, K. A., Kayani, A. C., Close, G. L., McArdle, A., & Lancaster, M. K. (2016). Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart. The journals of gerontology. Series A, Biological sciences and medical sciences, 71(8), 1005-1013. https://doi.org/10.1093/gerona/glv093

Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload

Kim, S., Choisy, S. C., Barman, P., Zhang, H., Hancox, J. C., Jones, S. A., & James, A. F. (2011). Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload. Circulation. Arrhythmia and electrophysiology, 4(5), 761-769. doi:10.1161/CIRCEP.111.964783

Research interests

My research revolves around changes in whole heart and cellular function with increasing age, from the perspectives of normal physiology and pathophysiology. My particular area of study are the changes in ionic regulation with age leading to the predisposition to arrhythmias, and other disorders of excitation and contraction within the elderly heart. Primarily my research group have used proteomics to examine the associated changes in protein expression and regulatory systems responsible for producing the age-associated changes in phenotype, coupled with functional measurements using electrophysiology. Recent targeted proteins in the mammalian heart have been the gap junctional subunit connexin43, the differing isoforms of the voltage-gated sodium ion channels and voltage-gated calcium ion channels. Our studies have conclude the change in expression of these ion channels expressed in the age heart, leave the age heart in a state of imbalance and experience high frequency of arrhythmias. Furthermore, we are now using interventions to protect the heart as it ages from the onset of associated pathologies, ranging from the global (e.g. exercise interventions), to the specific pharmaceutical agents (e.g. directed manipulation of signaling pathways), leading a novel approach to reduce AF events, to ultimately become a therapeutic strategy to prevent and treat AF in the elderly who are often unfit for surgery.

Postgraduate supervision

Dr Jones welcomes applicants with experience in mammalian physiology (at degree level) and specific knowledge of the heart. Applicants should understand how ion channels contribute and give rise to the normal action potential of the mammalian heart at a basic degree level, as her research focuses on cardiac dysfunction and how it arises (for example with ageing). The techniques used in the laboratory are proteomic, genomic and functional. At the time of appointment, specific projects will be offered in line with ongoing projects in the group.

Completed PhDs

- Stephanie Cooper, Age-associated changes in the expression of voltage-gated sodium channel isoforms found within the rat heart, 2013-2019 (as primary supervisor)

- Amy Dawson, Paper Microfluidics for Clinical Diagnostics Using Colorimetric Detection Methods, 2010-14 (as second supervisor)

- Dr Fiona Hatch, Age-Associated Changes to Calcium Handling Proteins across the Whole Heart, 2009-13 (as primary supervisor)

- Amy Dawson, Age-Dependent Expression and Distribution of Cardiac Progenitor Cells in the Adult Heart, 2009-10 (Research MSc, as primary supervisor)

Current MD supervisions

-Dr Emmanuel Isaac, Discovering mechanisms of AF. 2018-20

(Primary supervisor Sandra Jones, second supervisor Prof M Loubani)