- BSc (Aberystwyth University)
- PhD (Cardiff University)
- PGCert (University of Hull)
I am a Reader in Biomedical Sciences at the University of Hull. I have a BSc Genetics from University of Aberyswyth (1991) and a PhD from the University of Wales College of Medicine Cardiff (1995). I then worked at the University of Toronto as a postdoctoral fellow and started my own research group at King's College London in 1999.
I am interested in identifying antigens as targets for immunotherapy (where the immune system is stimulated to kill diseased cells) but we have also realised that disease-specific proteins can provide insights into the biology of disease and biomarkers for disease stage and survival.
Currently we are looking for antigenic targets for the targeted therapy of adult B-cell acute lymphocytic leukaemia, colon and ovarian cancer, as well as endometriosis and incidental lung nodules. We have shown that antigens can act as biomarkers for disease (diagnosis, survival and subtype) as well as providing new insights into the biology underlying these difficult to treat diseases.
Undergraduate - BSc Programmes
- Human Genetics
- Professional and Research Skills for Biomedical Sciences
- Final Year Independent Projects
- Molecular and Cell Biology
Postgraduate - MSc Programmes
- Research Project and Dissertation
Perspectives of General Practitioners on the issues surrounding the late diagnosis of Alzheimer’s disease
Bature, F., Guinn, B., Pang, D., The Luton, Dunstable, Milton Keynes General Practise consortium, , & Pappas, Y. (2018). Perspectives of General Practitioners on the issues surrounding the late diagnosis of Alzheimer’s disease. Journal of Alzheimer's Disease Reports, 2(1), 207-212. https://doi.org/10.3233/adr-180064
Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia
Freire Boullosa, L., Savaliya, P., Bonney, S., Orchard, L., Wickenden, H., Lee, C., …Guinn, B. (2017). Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia. BMC research notes, 9, 3853-3866. https://doi.org/10.18632/oncotarget.23380
Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design
Bature, F., Pang, D., Robinson, A., Polson, N., Pappas, Y., & Guinn, B. (2018). Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design. Current Alzheimer Research, 15(8), 723-730. https://doi.org/10.2174/1567205015666180404155358
My research interests focus around antigen identification reflecting my own background in genetics, immunology and cancer research. We use a range of techniques to identify and characterise antigens including SEREX, proto-arrays, cDNA expression arrays, qPCR and pMHC arrays.
I am particularly interested in identifying new biomarkers for difficult to diagnose diseases such as endometriosis, ovarian cancer and lung nodules that develop into cancer. These are often difficult to treat diseases because of their late diagnosis.
Dr Guinn welcomes applications from students who want to study postgraduate research degrees (MSc by Research and PhD). I am particularly interested in difficult to diagnose and/or treat diseases. To date this has included acute leukaemias, colon, ovarian and lung cancer, and endometriosis, and has led to the identification of biomarkers for survival, target for therapies and improved our understanding of the biological basis of disease.
For more information about possible PhD projects please contact email@example.com