About this project
Emerging evidence from preclinical and clinical studies shows that exercise during chemo-radiotherapy cycles has the potential to improve cancer treatment efficacy. Purported mechanisms include enhanced targeting of chemo-radiotherapy treatments via exercise-induced modulation of the tumour vasculature and favourable changes to the tumour microenvironment. This PhD project will establish how exercise can be embedded within the cancer care pathways for oesophagogastric and colorectal cancer patients undergoing neoadjuvant chemo-radiotherapy and radical chemo-radiotherapy as a definitive non-surgical option. The effects of exercise on treatment efficacy will then be assessed by comparison of radiological and biological tumour response rates between patients randomised to exercise in addition to standard care versus standard care alone.
You will be joining a large multidisciplinary team with a strong track record of leading research trials (including randomised controlled exercise trials) in people living with and beyond cancer. Working in a supportive, collegiate environment, you will have outstanding career development opportunities through the support provided by the Doctoral College and access to research seminars and workshops in the Department of Sport, Health & Exercise Science, the Hull York Medical School and the Hull University Teaching Hospitals NHS Trust. You will also engage in regular meetings with other PhD students and supervisors working on related projects as part of the larger research cluster.
For informal enquiries, please contact Professor John M Saxton: firstname.lastname@example.org
About the research cluster
Exercise brings numerous proven health benefits to people living with and beyond cancer. Recently, preclinical and clinical studies have shown that exercise during chemo-radiotherapy cycles has potential to improve treatment efficacy, while also helping to ameliorate the well-established cardiotoxic and myotoxic side-effects. This PhD cluster aims to develop an exercise model that can be embedded within the oesophagogastric and colorectal cancer care pathways and provide evidence that it can influence and potentially improve the efficacy of chemo-radiotherapy treatments. In addition, the cluster aims to provide new mechanistic insights into the role of exercise for ameliorating the adverse cardiotoxic and myotoxic side-effects of chemo-radiotherapy and undertake qualitative investigations aimed at understanding the barriers and levers to embedding exercise within cancer care pathways and informing the development of good practice implementation guidelines.
Click here to watch a recording of our recent webinar about this funded postgraduate research opportunity. You'll hear from programme leaders, supervisors, and students and listen to queries from other applicants in the Q&A.
Other PhDs in this cluster
Exercise for ameliorating the cardiotoxic side-effects of chemo-radiotherapy in patients diagnosed with oesophagogastric and colorectal cancers
Exercise for attenuating the myotoxic side-effects of chemotherapy
Patient and health professional perceptions of embedding exercise into the cancer chemo-radiotherapy treatment pathways: a qualitative study