About this project
This PhD project aims to provide novel data on the cellular mechanisms involved in the myotoxic effects of chemotherapy, which include atrophy and senescence via increased proteolysis and autophagy and decreased protein synthesis. Platelet releasate contains growth factors which have potent mitogenic and angiogenic effects on muscle. This project will induce senescence in muscle cell lines (in vitro) by doxorubicin treatment and determine whether platelet releasate inhibits senescence, and whether the response is influenced by exercise. Clinical work with oesophagogastric and colorectal cancer patients will involve assessing myopenia/sarcopenia between patients randomised to exercise plus standard care or standard care alone.
You will be joining a large multidisciplinary team with a strong track record of leading research trials (including randomised controlled exercise trials) in people living with and beyond cancer. Working in a supportive, collegiate environment, you will have outstanding career development opportunities through the support provided by the Doctoral College and access to research seminars and workshops in the Department of Sport, Health & Exercise Science, the Hull York Medical School and the Hull University Teaching Hospitals NHS Trust. You will also engage in regular meetings with other PhD students and supervisors working on related projects as part of the larger research cluster.
For informal enquiries, please contact Dr Antonios Matsakas.
About the research cluster
Exercise brings numerous proven health benefits to people living with and beyond cancer. Recently, preclinical and clinical studies have shown that exercise during chemo-radiotherapy cycles has potential to improve treatment efficacy, while also helping to ameliorate the well-established cardiotoxic and myotoxic side-effects. This PhD cluster aims to develop an exercise model that can be embedded within the oesophagogastric and colorectal cancer care pathways and provide evidence that it can influence and potentially improve the efficacy of chemo-radiotherapy treatments. In addition, the cluster aims to provide new mechanistic insights into the role of exercise for ameliorating the adverse cardiotoxic and myotoxic side-effects of chemo-radiotherapy and undertake qualitative investigations aimed at understanding the barriers and levers to embedding exercise within cancer care pathways and informing the development of good practice implementation guidelines.
Click here to watch a recording of our recent webinar about this funded postgraduate research opportunity. You'll hear from programme leaders, supervisors, and students and listen to queries from other applicants in the Q&A.
Other PhDs in this cluster
Exercise for improving chemo-radiotherapy efficacy in patients diagnosed with oesophagogastric and colorectal cancers
Exercise for ameliorating the cardiotoxic side-effects of chemo-radiotherapy in patients diagnosed with oesophagogastric and colorectal cancers
Patient and health professional perceptions of embedding exercise into the cancer chemo-radiotherapy treatment pathways: a qualitative study