About this project
The aim of the project is to synthesise a candidate “theranostic” agent for advancement to clinical trials. The term theranostic refers to the combination of a THERApeutic component and a diagNOSTIC component in a single molecule, in this case the therapeutic component will be a photodynamic sensitiser, which can destroy tumours when activated with visible light, and the diagnostic component will be a ligand system suitable for binding the positron emitting isotope gallium-68.
The team involved in the project is made up of Professor Boyle (Hull), Dr Graeme Stasiuk (KCL) and Professor Alexander MacRoberts & Dr Kerstin Sanders (UCL) as the project lead investigators, and is supported by postdoctoral researchers and PhD students in all four laboratories.
The scholarship is part of a larger project involving collaborators at Kings College and University College, London.
The successful student will be based in Hull but will have the opportunity to visit the laboratories of collaborators in London to learn techniques and test compounds synthesised in Hull.
You will primarily be involved in synthesising and testing the therapeutic component of the system but will have the opportunity to learn radio-imaging both at the Hull Centre for Molecular Imaging and radio-imaging laboratories at KCL and UCL.
You will join the research group of Professor Ross Boyle, who leads the Photobiology & Photomedicine section based in the Department of Chemistry. The group is well resourced and occupies two laboratories, one devoted to synthesis of light activated molecules, and the second devoted to photobiological investigations of those molecules. The group comprises two postdoctoral research assistants and three PhD students and is equipped with all the synthetic, spectroscopic and biological equipment required for the project.