Therapeutic exploration of the radiobiological tumour Funding: Funded PhD Duration: 3 years (full-time) Application deadline: Wednesday 23 January How to apply About this project The tumour microenvironment is a major driver of cancer progression and spread and is associated with poor prognosis in patients. In particular low oxygen (hypoxia) signalling is associated with increased radiotherapy resistance. The understanding of radiobiological hypoxia but still under-represented area of cancer research. This project will evaluate the use of clinically relevant targeted molecular therapies as potential novel radio-sensitisers in hypoxia. This exciting project encompasses varied approaches and instruments, including 2D and 3D in vitro models of radiation response, specialised hypoxia facilities, and our unique NPL (National Physics Laboratory)-validated irradiator. The successful candidate will be expected to have a solid knowledge base in cell biology and molecular biology, and, ideally, knowledge on cancer biology. The candidate must also show a willingness to work in a multi-disciplinary project and environment, and undertake extensive radiobiology methodology training. Supervisors We recommend contacting a supervisor to discuss your research proposal before making an application. Dr Isabel Pires Professor Steve Archibald About Postgraduate Research at Hull The University's Postgraduate Training Scheme (PGTS) provides a range of generic and discipline-specific modules to support research students through their programme. Find out more The library has an exclusive lounge for postgraduate research students and a dedicated Skills Team to provide a wide range of study and research skills help. Find out more The Graduate School provides support to postgraduate research students. Offering skills development opportunities and dedicated facilities, the school is here to help you achieve your potential. Find out more Research at Hull tackles big challenges and makes an impact on lives globally, every day. Our current research portfolio spans everything from health to habitats, food to flooding and supply chains to slavery. Find out more Funding Full-time UK/EU and International PhD Scholarships will include tuition fees and maintenance (£14,777 in 2018/19) for three years, depending on satisfactory progress. Entry requirements Applicants should have a 1st class undergraduate degree in Biomedical Science, Cancer Biology, Biochemistry, or a related discipline, or a Masters level research qualification in a relevant discipline. A 2:1 may be considered, if combined with relevant experience. Interviews will be held between 7 and 27 February 2019. Successful applicants will be informed of the award as soon as possible and by 15 March 2019 at the latest. Studentships will start on 16 September 2019.