Professor Steve Archibald

Professor Steve Archibald

Professor in Molecular Imaging

Summary

Research areas in the Archibald group are PET probe development, chemokine receptor imaging and lab-on-a-chip/ microfluidic devices for radiosynthesis and quality control.

Prof Archibald was awarded a first class BSc degree in Chemistry, Life Systems and Pharmaceuticals by the University of York in 1992 and a PhD in Chemistry by the University of Edinburgh in 1995.

He carried out postdoctoral research at the Universities of Paris-Sud (France), Kansas (USA) and York (UK), before being appointed as a lecturer at the University of Hull in 2000.

Prof Archibald was promoted to Senior Lecturer in 2008, Reader in 2011, Director of the Positron Emission Tomography Research Centre in 2013 and Professor in 2014.

Recent outputs

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Journal Article

Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform

Yang, Z., Barnes, C., Domarkas, J., Koch-Paszkowski, J., Wright, J., Amgheib, A., …Allott, L. (2023). Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform. Reaction Chemistry and Engineering, 8(10), 2403-2407. https://doi.org/10.1039/d3re00307h

Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−

Price, T. W., Renard, I., Prior, T. J., Kubíček, V., Benoit, D. M., Archibald, S. J., …Stasiuk, G. J. (2022). Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−. Inorganic chemistry, 61(43), 17059–17067. https://doi.org/10.1021/acs.inorgchem.2c01992

Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release

Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., …Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017

A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms

Barnes, C., Nair, M., Aboagye, E. O., Archibald, S. J., & Allott, L. (2022). A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms. Reaction Chemistry and Engineering, https://doi.org/10.1039/d2re00219a

The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

Archibald, S. J., & Allott, L. (2021). The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules. EJNMMI Radiopharmacy and Chemistry, 6(1), Article 30. https://doi.org/10.1186/s41181-021-00141-0

Lead investigator

Project

Funder

Grant

Started

Status

Project

Development of novel acyclic chelates for gallium-68 and scandium-44 radiometals used in PET

Funder

EPSRC Engineering & Physical Sciences Research Council

Grant

£136,858.00

Started

14 June 2021

Status

Ongoing

Project

CageTag: Caged Theranostics as a Universal Platform for Nuclear Medicine

Funder

EPSRC Engineering & Physical Sciences Research Council

Grant

£481,520.00

Started

1 April 2022

Status

Ongoing

Project

Translational Research in the Molecular Imaging Research Centre

Funder

Daisy Appeal

Grant

£45,560.00

Started

1 August 2016

Status

Complete

Project

CXCR7/CXCR4 dual receptor cancer theranostics with copper 64 PET imaging

Funder

MRC Medical Research Council

Grant

£63,995.00

Started

1 July 2020

Status

Complete

Project

New technology to improve capability for clinical radiopharmaceutical production

Funder

MRC Medical Research Council

Grant

£564,548.00

Started

1 January 2019

Status

Complete

Project

Positron Emission Tomography research

Funder

Daisy Appeal

Grant

£59,999.00

Started

1 March 2016

Status

Complete

Project

Training scientists to develop and Image materials for Tissue Engineering and Regenerative Medicine (iTERM)

Funder

EC European Commission

Grant

£235,084.00

Started

1 October 2013

Status

Complete

Project

Radiopharmacy GMP radiotracer production

Funder

Daisy Appeal

Grant

£39,500.00

Started

1 February 2023

Status

Complete

Project

PreclinHUPET2: Enabling Enhanced Preclinical Nuclear Imaging For The North Of England

Funder

MRC Medical Research Council

Grant

£657,700.00

Started

1 February 2023

Status

Complete

Co-investigator

Project

Funder

Grant

Started

Status

Project

TRANSFORM: Reducing Inequalities in Cancer Outcomes in Yorkshire: Realising our potential for innovation in Diagnosis, Patient Management, Survivorship and Palliative Care Research

Funder

YCR Yorkshire Cancer Research

Grant

£1,806,650.00

Started

1 September 2017

Status

Ongoing

Project

Translational nanoconstructs for targeted tissue accumulation and guided surgery in cancer

Funder

EPSRC Engineering & Physical Sciences Research Council

Grant

£572,613.00

Started

1 May 2023

Status

Ongoing

Project

TARGETING THE MYOSIN LIGHT CHAIN PHOSPHATASE WITH PEPTIDE DISRUPTORS: A NOVEL ANTIPLATELET THERAPEUTIC APPROACH

Funder

British Heart Foundation

Grant

£110,680.00

Started

3 July 2023

Status

Ongoing

Project

Medical Imaging Alliance: Siberia and Hull

Funder

British Council

Grant

£37,600.00

Started

3 September 2018

Status

Complete

Postgraduate supervision

Prof Archibald welcomes applications in all aspects of medical imaging science and positron emission tomography, particularly

- nuclear imaging (PET and SPECT)

- molecular imaging probe development

- radiochemistry

- use of radiometals

- development of receptor protein targeting (small molecules, peptides and antibodies)

- targeted radionuclides for therapy

- radiopharmacy and translational research

Completed PhDs

- Cheryll Allan (2005)

- Christopher Fisher (2005)

- Gary Nicholson (2006)

- Jon Silversides (2006)

- Amanda Sparke (2008)

- Christopher Welch (2009) (2nd Supervisor)

- Graeme McRobbie (2009)

- Ryan Mewis (2009)

- Abid Khan (2010)

- Rachel Smith (2013)

- Benjamin Burke (2013)

- Naomi Jones (2015) (2nd Supervisor)

- Kati Nicholson (2015)

- Ali Al-Zirgani (2016)

- Neazar Baghdadi (2016)

- Seraj Omar Al-Zahrani (2016)

- Mustafa Al-Yassiry (2016)

- Bassim Wahaab (2016)

- David Millar (2016) (2nd supervisor)

- Shubhanchi Nigam (2017)

- Alicja Kownacka (2017)

Current PhD supervisions

- Zainab Abdallah Al-Ali

- Boon-Uma Jowanarhidi

- Hayley Bignell

- Tahani Alresheedi

- Fada Jabber

- Rhiannon Lee

- Isaline Renard

- Rebecca Ullah (2nd supervisor)

- James Thompson (2nd supervisor)

- Noemi Perujo Holland (2nd supervisor)

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