Lynn Cawkwell

Dr Lynn Cawkwell

Senior Lecturer in Cancer Genetics

Faculty and Department

  • Faculty of Health Sciences
  • Department of Biomedical Sciences

Summary

Dr Lynn Cawkwell has been a lecturer in cancer genetics at the University of Hull since 1999. She is also a member of the Joint Centre for Cancer Studies at Hull York Medical School and has responsibility for the Daisy Tumour Bank at Castle Hill Hospital. Dr Cawkwell's research concerns the identification and validation of cancer biomarkers. She gained her BSc in Genetics from the University of Liverpool before completing a PhD in Molecular Oncology at the University of Leeds, School of Medicine, where she went on to a postdoctoral appointment in molecular pathology.

Journal Article

Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease

Lin, T. T., Norris, K., Heppel, N. H., Pratt, G., Allan, J. M., Allsup, D. J., …Pepper, C. (2014). Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease. British journal of haematology, 167(2), 214-223. https://doi.org/10.1111/bjh.13023

Clinical response to primary letrozole therapy in elderly patients with early breast cancer : possible role for p53 as a biomarker

Garimella, V., Hussain, T., Agarwal, V., Radhakrishna, S., Fox, J. N., Kneeshaw, P. J., …Cawkwell, L. (2014). Clinical response to primary letrozole therapy in elderly patients with early breast cancer : possible role for p53 as a biomarker. International journal of surgery, 12(8), 821-826. https://doi.org/10.1016/j.ijsu.2014.06.009

Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen

Kashuba, E., Eagle, G. L., Bailey, J., Evans, P., Welham, K. J., Allsup, D., & Cawkwell, L. (2013). Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen. Journal of Proteomics, 91, (478-485). doi:10.1016/j.jprot.2013.08.002. ISSN 1874-3919

Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome

Till, K. J., Allen, J. C., Talab, F., Lin, K., Allsup, D., Cawkwell, L., …Slupsky, J. R. (2017). Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome. Scientific reports, 7(1), https://doi.org/10.1038/s41598-017-17021-w

The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers

Kashuba, E., Bailey, J., Allsup, D., & Cawkwell, L. (2013). The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers. Biomarkers, 18(4), (279-296). doi:10.3109/1354750x.2013.787544. ISSN 1354-750X

Research interests

The application of cancer proteomics to - identify biomarkers of response to anticancer therapy - identify novel therapy targets or therapy strategies - investigate the molecular mechanism of action of novel anticancer agents

Postgraduate supervision

Dr Cawkwell welcomes applications in cancer biobanking, cancer biomarker discovery and cancer biomarker validation. She welcomes applicants with experience in cancer biomarkers, biomarker discovery or cancer biobanking and specific knowledge of proteomics, bioinformatics, radiotherapy resistance, rectal cancer oesophageal or chronic lymphocytic leukaemia. The techniques used in the laboratory are biobanking, histology, tissue microarrays, immunohistochemistry, proteomics, protein assays and bioinformatics. At the time of appointment, specific projects will be offered in line with ongoing research in the group. Completed PhDs - Dr Helen Berrieman, Resistance to chemotherapy in non-small cell lung cancer - Dr Mark Watson, Molecular markers of response to breast cancer therapy - Dr Laura Smith, The proteomic analysis of resistance to anticancer therapy in human breast cancer - Dr Gina Eagle, The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia - Dr James Bailey, The proteomic analysis of signalling pathways in chronic lymphocytic leukaemia - Dr Victoria Hodgkinson, The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics - Dr Lucy Scaife, Proteomic identification of putative biomarkers of radiotherapy resistance - Dr Vijay Agarwal, The significance of the EGFR pathway in malignant pleural mesothelioma - Dr Elena Kashuba, The kinin-kallikrein system in chronic lymphocytic leukaemia - Dr Bashak Onal, Towards developing a screening assay for predicting biomarkers of radioresistance - Dr Lily Oguh, EGFR and related therapeutic targets in malignant pleural mesothelioma - Mr Richard Baker, MD, Genetic Analysis of Colorectal Cancer - Mr Luke Condon, MD, The role of chromosome 22 in the progression of head and neck squamous cell carcinoma - Mr Paul Nix, MD, Radioresistant Laryngeal Cancer - Miss Nala Sivarajasingham, MD, Role of chromosome 13 in colorectal cancer - Mr Edward Smyth, MD, An immunohistochemical investigation into the basis for improved survival in mismatch repair deficient colonic cancers - Miss Harriet Patmore, MD, Cytogenetic analysis of head and neck cancer - Mr Veerabhadram Garimella, MD, Molecular heterogeneity of multifocal invasive ductal carcinoma of the breast - Mr Justin Murphy, MD, Biomarkers of radioresistance in oral cancer - Miss Alexandra Murray, MD, Novel anti-endothelial therapeutic strategies in malignant melanoma - the metronomic approach - Miss Dalia ELFadl, MD, Proteomic identification and validation of biomarkers associated with resistance to radiotherapy in breast cancer - Mr Omar Tillo, MD, Endothelial Microparticles in the Plasma of Renal Cancer Patients Treated With Sunitinib - Mr Sajid Mehmood, MD, Identification of putative biomarkers of resistance to radiotherapy in rectal cancer - Mr Tasadooq Hussain, MD, Proteomic identification of putative biomarkers of neoadjuvant chemotherapy resistance in luminal (ER+) breast cancer Current PhD supervisions - Miss Sharjeela Tariq, MD, The investigation of novel drug targets in mesothelioma