Justin_Sturge

Dr Justin Sturge

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Summary

Dr Sturge is a cell biologist who leads the Endo180 Cancer Team, the winners of the Educate North Research Team Of The Year in 2016. His post-doctoral work was conducted with Professor Gareth E Jones at King's College London (1998-2001) and Professor Clare M Isacke at the Institute of Cancer Research (2001-2006). Dr Sturge was appointed Non-Clinical Lecturer at Imperial College London (2006-2011), Senior Lecturer in the School of Biological, Biomedical and Environmental Sciences, University of Hull (2012-2016) and Reader in the School of Life Sciences, University of Hull (2016). For more information see his blog. EDUCATE North Research Team Of The Year (2016). Pancreatic Cancer UK strategy panel member (2016). Established Hull Prostate Cancer Interest Group (2016). Organised and chaired National Prostate Cancer Research Symposium (London, 2010) and Prostate Cancer Charity Symposium (London, 2011). Regularly feature in University of Hull and funder press releases leading to media interviews, press, TV and radio coverage; including Hull Daily Mail, Prostate Cancer News Today, Medical Xpress, Renal and Urology News (November 2014); Hull Daily Mail and interview on KCFM radio (March 2014); Yorkshire Post (January 2013); Prostate Cancer Charity research news (December 2011); Association of International Cancer Research video (January 2011); Prostate Cancer Charity video (November 2010); Times Careers Section (November 2007); Washington Post, The Times, The Daily Mail, London Evening Standard, The Metro, BBC News Online and ITN News (September 2003). Research case studies highlighted in University of Hull's Annual Report (2015/16), Venn Alumni magazine (2015/16), Research Brochure (2015/16, 2014/15), and featured on campus billboards promoting research breakthroughs at the University (2016). Young Prostate Researchers Symposium, Cambridge (2009); Prostate Cancer Support Organisation, Basingstoke (2009); The Prostate Cancer Charity, London (2009, 2007), World Cancer Congress, Beijing (2009), Cancer and Bone Society, Heriott Watt University (2008), London Prostate Interest Group (2007). Invited seminar speaker at University of Cardiff (2016), University of Hull (2015, 2014, 2013), University of Texas (2012), University of East Anglia (2012), University of Birmingham (2009), Department of Investigative Medicine, Imperial College London (2009), Queen Mary University London (2008), CRUK Lincolns Inn (2007), INSERM Paris (2007); National Cancer Research Institute, Birmingham (2006). Honor Fell Travel Awards (1999, 2002, 2004) from British Society for Cell Biology. British Society for Cell Biology Best Poster Prize (2004). Wellcome and Toulman Prizes for Excellence in Pharmacology (1991) at University of Portsmouth.

Undergraduate

Level 4 BSc Biomedical Science - Skills for Biomedical and Human Biology Sciences - Human Physiology - Cell Structure and Function Level 5 BSc Biomedical Science - Molecular Genetics and Proteomics - Molecular Cell Biology and Histopathology - Professional and Research Skills for Biomedical Scientists - Biological Basis of Disease - Molecular Cell Biology Level 6 BSc Biomedical Science - 20 Credit Research Project - 40 Credit Research Project - Cancer Biology - Reviews in Biomedical Science BSc Biochemistry - Reviews in Biochemistry Level 7 MSc Biomedical Science - Current Topics in Biomedical Science (Module Coordinator) - Research Skills in The Biosciences - Cellular and Molecular Biology of Cancer MSc Translational Oncology - Cellular and Molecular Biology of Cancer - Organ Specific Cancers: From-Bench-To-Bedside - Tumour Immunology and Microenvironment - Oncology Research Skills - Cancer and Modifiable Risks (Module Coordinator) - Research Project and Dissertation MSc Cancer Imaging - Organ Specific Cancers: From-Bench-To-Bedside MSc Cancer Rehabilitation - Cancer and Modifiable Risks (Module Coordinator)

Postgraduate

Dr Sturge welcomes enquiries from potential PhD and MSc (Res) students interested in exploiting the role of mechanobiology in chronic disease as a diagnostic and therapeutic target. Projects are particularly focused on the association between diabetes, metabolic disorders, obesity and the promotion of cardiovascular disease and cancer. His team has been the host laboratory for external Masters and Bachelors research project students from École Normale Supérieure de Lyon, Tokyo Medical & Dental University, University of British Columbia and University of Newcastle, as well as hosting postdoctoral fellows from Portugal, Czech Republic, Mexico and India. Dr Sturge has mentored junior research fellows, PhD students and lecturers since starting his first academic position at Imperial College London. Completed PhDs PhD - Julian Hendrik Gronau, The Role of Endo180 in Prostate Cancer Cell Migration and Metastasis, Imperial College London (2013) - Kai Wang, Investigating the Biological and Clinical Implications of Soluble Endo180, University of Hull (2017) MRes - Susann Bruche, Dual Impact of Altered Extracellular Matrix and Intracellular Signals Generated by S1P/SphK1 and the Collagen Modulating Receptor Endo180 during Cardiac Fibrosis, Imperial College London (2010) - Claudia Breit, The Role of Endo180 in Prostate Cancer Progression, Imperial College London (2010) - Kamil Talar, Stiffness Induced Disruption of Endo180-CD147 Suppressor Complex as a Biophysical Trigger for Invasive Pancreatic Cancer, university of Hull (2017) - George Firth, The Synthesis and Validation of Multimodal PET/Fluorescence Zinc Sensing Probes as Potential Imaging Agents for Prostate Cancer, University of Hull (2017) Current PhD supervisionsPhD - Mitchell Clarke,ENDOGLOWS: Development of a Multimodal Bioimaging Platform for Detecting the Switch to Aggressive Prostate Cancer, University of Hull (2015- ) MRes - Matthew Walker, The Role of Endo180 in Pancreatic Cancer Progression, University of Hull (2017- )

Journal Article

Synthesis of super bright indium phosphide colloidal quantum dots through thermal diffusion

Clarke, M. T., Viscomi, F. N., Chamberlain, T. W., Hondow, N., Adawi, A. M., Sturge, J., …Stasiuk, G. J. (2019). Synthesis of super bright indium phosphide colloidal quantum dots through thermal diffusion. Communications Chemistry, 2(1), https://doi.org/10.1038/s42004-019-0138-z

A 18F radiolabelled Zn(ii) sensing fluorescent probe

Price, T. W., Firth, G., Eling, C. J., Kinnon, M., Long, N. J., Sturge, J., & Stasiuk, G. J. (2018). A 18F radiolabelled Zn(ii) sensing fluorescent probe. Chemical communications : Chem comm / the Royal Society of Chemistry, 54(26), 3227-3230. doi:10.1039/c8cc00687c

How to study basement membrane stiffness as a biophysical trigger in prostate cancer and other age-related pathologies or metabolic diseases

Rodriguez-Teja, M., Breit, C., Clarke, M., Talar, K., Wang, K., Mohammad, M. A., …Sturge, J. (2016). How to study basement membrane stiffness as a biophysical trigger in prostate cancer and other age-related pathologies or metabolic diseases. Journal of visualized experiments : JoVE, 2016(115), doi:10.3791/54230

Endo180 at the cutting edge of bone cancer treatment and beyond

Sturge, J. (2016). Endo180 at the cutting edge of bone cancer treatment and beyond. Journal of Pathology, 238(4), 485-488. doi:10.1002/path.4673

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces

Caley, M. P., King, H., Shah, N., Wang, K., Rodriguez-Teja, M., Gronau, J. H., …Sturge, J. (2016). Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces. Clinical & experimental metastasis, 33(2), 151-165. https://doi.org/10.1007/s10585-015-9765-7