Torch

Dr James Hobkirk

Lecturer in Physiology

Faculty and Department

  • Faculty of Health Sciences
  • School of Life Sciences

Summary

Programme director for Applied Exercise Science for Health/ Research Ethics Committee, Physiology/ Health and Safety Officer

Dr James Hobkirk joined the Department of Sport, Health and Exercise Science in April 2015 as a lecturer in physiology.

He received his PhD, entitled Hypertriglyceridaemia, small dense low-density lipoproteins and cardio-metabolic risk stratification in paediatric obesity, in 2011.

James is scientific director and an honorary scientist in the Department of Cardiothoracic Surgery at the Hull and East Yorkshire NHS Trust.

He collaborates with international academics and clinicians, and is a member of the Royal Society of Medicine, an expert reviewer for the Health Research Authority and sits on the editorial board of a clinical journal.

Journal Article

The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome

Sathyapalan, T., Hobkirk, J. P., Javed, Z., Carroll, S., Coady, A., Pemberton, P., …Atkin, S. L. (2019). The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome. Frontiers in endocrinology, 10, https://doi.org/10.3389/fendo.2019.00394

Exploring quality of life in patients with and without heart failure

Zhang, J., Hobkirk, J., Carroll, S., Pellicori, P., Clark, A. L., & Cleland, J. G. (2016). Exploring quality of life in patients with and without heart failure. International journal of cardiology, 202, 676-684. https://doi.org/10.1016/j.ijcard.2015.09.076

Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure

Damy, T., Hobkirk, J., Walters, M., Ciobanu, A., Rigby, A. S., Kallvikbacka-Bennett, A., …Cleland, J. G. F. (2015). Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure. Journal of Cardiovascular Pharmacology, 66(3), 229-238. https://doi.org/10.1097/fjc.0000000000000262

In vitro modulation of the LPS-Induced proinflammatory profile of hepatocytes and macrophages - Approaches for intervention in obesity"

Kheder, R. K., Hobkirk, J., & Stover, C. M. (2016). In vitro modulation of the LPS-Induced proinflammatory profile of hepatocytes and macrophages - Approaches for intervention in obesity?. Frontiers in Cell and Developmental Biology, 4, https://doi.org/10.3389/fcell.2016.00061

Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice

Carroll, S., Hobkirk, J., Browning, M. J., Janus, J., Kheder, R., Saeed, Z., & Stover, C. (2017). Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice. Immunity, Inflammation and Disease, 5(2), 151-154. https://doi.org/10.1002/iid3.154

Postgraduate supervision

James currently co-supervises a number of postgraduate students within the remit of pathophysiology of human disease, metabolic dysregulation and organ specific lipotoxicity. He is particularly interested in the mechanisms and treatment of metabolic dysregulation in the blood and at the tissue and cellular level via nutritional, exercise and pharmaceutical therapies.

Completed PhDs

- Mr Ramiar Kheder, Nutritional strategies to reduce lipogenesis, inflammation and fibrosis in mouse hepatic tissue, isolated macrophages and Hep G2 cells (PhD, with Dr C Stover, University of Leicester)

Current PhD supervisions

- Mr Yama Haqzad, Lipogenic and oxidative gene profiles controlling myocardial energy metabolism (MD)

- Mr Zaheer Tahir, Modulating cardiac energy metabolism in ex vivo right atria and human cardiomyocytes with dicholoracetatev (MD)