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Dr Huw Jones

Lecturer in Biochemistry

Faculty and Department

  • Faculty of Science and Engineering
  • Department of Chemistry and Biochemistry

Qualifications

  • PCAP (University of Hull)

Summary

Dr Jones is a lecturer in biochemistry, with research interests in the modulation of health and disease states by natural products.

He is particularly interested in how chemicals found within the diet can act as medicinal drugs, particularly in terms of modulating redox signaling and oxidative stress.

This research uses a variety of cell culture models, in addition to collaborations with clinicians and physiologists, to undertake research at the tissue and human levels.

Dr Jones contributes to the delivery and teaching of BSc / MBiochem and MSc Biochemistry, criminology and forensic sciences, chemistry, biomedical sciences and MSc Pharmacology and drug development (HYMS) programmes.

Undergraduate

Year 1

- Insights into biochemistry

- Introduction to DNA and chromatography

- Protein biochemistry

- Biochemistry (biomedical sciences)

Year 2

- Biochemistry and professional skills 1

- Biochemistry and professional skills 2

- Forensic science in practice

Year 3

- Biochemistry group project

- Concepts in pharmacology

- Reviews in biochemistry

- Chemical characterisation and separation

Year 4

- Recent developments in biochemistry

- Biochemistry project literature review

- Biochemistry research project

- Advanced biochemistry

- Preparation for research for biochemists

- Advanced research topics in biochemistry

- Literature review and preparation for project

- Research project

- Techniques in drug discovery 1

Journal Article

Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade

Magwenzi, S., Woodward, C., Wraith, K. S., Aburima, A., Raslan, Z., Jones, H., …Naseem, K. M. (2015). Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade. Blood, 125(17), 2693-2703. doi:10.1182/blood-2014-05-574491

The dietary flavonol quercetin ameliorates angiotensin II-induced redox signaling imbalance in a human umbilical vein endothelial cell model of endothelial dysfunction via ablation of p47???? expression

Jones, H. S., Gordon, A., Magwenzi, S. G., Naseem, K., Atkin, S. L., & Courts, F. L. (2016). The dietary flavonol quercetin ameliorates angiotensin II-induced redox signaling imbalance in a human umbilical vein endothelial cell model of endothelial dysfunction via ablation of p47???? expression. Molecular Nutrition and Food Research, 60(4), 787-797. https://doi.org/10.1002/mnfr.201500751

Pilot investigation of a virtual gastric band hypnotherapy intervention

Greetham, S., Goodwin, S., Wells, L., Whitham, C., Jones, H., Rigby, A., …Atkin, S. (2016). Pilot investigation of a virtual gastric band hypnotherapy intervention. International Journal of Clinical and Experimental Hypnosis, 64(4), 419-433. https://doi.org/10.1080/00207144.2016.1209037

The effects of acute interval exercise and strawberry intake on postprandial lipemia

O’Doherty, A., Jones, H. S., Sathyapalan, T., Ingle, L., & Carroll, S. (2017). The effects of acute interval exercise and strawberry intake on postprandial lipemia. Medicine and Science in Sports and Exercise, 49(11), 2315-2323. https://doi.org/10.1249/MSS.0000000000001341

Research interests

- pharmacological effects of natural products in health and disease states

- analytical approaches to the measurement of reactive oxygen species and oxidative stress markers

- novel methods for the synthesis of human circulating metabolites of xenobiotics and natural products

Postgraduate supervision

Dr Jones welcomes applications in

- pharmacological effects of natural products in health and disease states

- analytical approaches to the measurement of reactive oxygen species and oxidative stress markers

- novel methods for the synthesis of human circulating metabolites of xenobiotics and natural products

Completed PhDs:

- Eleanna Chalari (as co-supervisor), The effects of intermittency and acceleration on exercise-induced oxidative stress after high-intensity intermittent exercise (2017)

Current PhD supervisions

- Nikki Simpson, Effect of coenzyme Q10 supplementation upon skeletal muscle oxidative signaling in vitro and in vivo (as co-supervisor)

- Rachel Burke, Nitrate supplementation and vascular function (as co-supervisor)

- Nathan Hayes, The development of an in vitro model of skeletal muscle ageing, and its application to the screening of dietary polyphenols for pharmacological effects (primary supervisor)

- Bradley Doyle, Development of a novel microfluidic-based synthetic reactor for the production of human circulating metabolites of drugs and natural products (primary supervisor).

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