fiona-frame

Dr Fiona Frame

Lecturer in Cancer Biology

Faculty and Department

  • Faculty of Health Sciences
  • Department of Biomedical Sciences

Qualifications

  • BSc (University of Edinburgh)
  • PhD (University of Edinburgh)
  • MA (University of York)

Undergraduate

- Passionate teacher, mentor and facilitator for students and colleagues, as well as proponent of outreach work with school children, fundraisers and patients.

Journal Article

Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance

Frame, F. M., & Maitland, N. J. (2019). Epigenetic Control of Gene Expression in the Normal and Malignant Human Prostate: A Rapid Response Which Promotes Therapeutic Resistance. International Journal of Molecular Sciences, 20(10), https://doi.org/10.3390/ijms20102437

Effects on prostate cancer cells of targeting RNA polymerase III

Petrie, J. L., Swan, C., Ingram, R. M., Frame, F. M., Collins, A. T., Dumay-Odelot, H., …White, R. J. (2019). Effects on prostate cancer cells of targeting RNA polymerase III. Nucleic Acids Research, 47(8), 3937-3956. https://doi.org/10.1093/nar/gkz128

Phenotype-independent DNA methylation changes in prostate cancer

Pellacani, D., Droop, A. P., Frame, F. M., Simms, M. S., Mann, V. M., Collins, A. T., …Maitland, N. J. (2018). Phenotype-independent DNA methylation changes in prostate cancer. The British journal of cancer / Cancer Research Campaign, 119(9), 1133-1143. https://doi.org/10.1038/s41416-018-0236-1

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer

Butler, D. E., Marlein, C., Walker, H. F., Frame, F. M., Mann, V. M., Simms, M. S., …Maitland, N. J. (2017). Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer. Oncotarget, 8(34), 56698-56713. https://doi.org/10.18632/oncotarget.18082

Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments

Packer, J. R., Hirst, A. M., Droop, A. P., Adamson, R., Simms, M. S., Mann, V. M., …Maitland, N. J. (2019). Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments. FEBS Letters, https://doi.org/10.1002/1873-3468.13589

Research interests

- Research area is prostate cancer with an interest in therapy resistance, using primary prostate epithelial cells from patient samples as a clinically relevant model.

- Preferred research style is collaborative working, within and across institutions, with a bias for interdisciplinary projects and academic-industry partnerships.

Membership/Fellowship of professional body

Fellow of The Higher Education Academy

2015