Research
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| - Minaturised analytical systems
| - Microwave enhanced chemistry
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In 1983 determined to develop better analytical methodology to characterise and model chemical reactions Steve Haswell started, as many did at that time, to explore the application of multivariate statistical measurements or as we know it today chemometrics. It quickly became apparent however that the spatial and temporal limitation of the measurement process was going to be a problem, so a way was needed to either make the measurement process as big as the entire reactor or make the reactor as small as the measurement probe. As is so often the case, nature had already sorted out this problem through the use of scale to control the fluidics of complex chemical processes in what we know as the cell, using built in detectors on the very high surfaces or membranes present.
So began the road of discovery which continues to this day that not only enters the exciting field of multidisciplinary scientific research but also touches on the deep felt prejudices and politics which malign international research and the ruthless world of commercialisation, all straight out of one of today’s best selling novels.
Current areas of ongoing research at Hull in the field of miniaturisation include: (i) the application of micro reactor methodology for atom efficient synthesis, (ii) development and design of reactors for microwave assisted chemistry in lab and pilot scale, (iii) microfluidic sorting , processing and analysis of viable cells, (iv) at crime scene DNA characterisation, and (v) synthesis and nanotechnological applications of tethered silicates.
Current research grants include the following. Biologically functionalised surfaces for cell processing (NMT Project 366 - £180k and FP6 project 033254 - £188k), reaction intensification (GR/S34106 - £213k), energy management using microwaves (GR/R50349 - £131,438), in situ electrochemistry (GR/S34267 - £215k), detection and systems integration (EP/D040930 - £721k). We plan to extend our current research portfolio to design and validate novel microfluidic based methodology to create analytical tools for the monitoring and characterization of specific cell functions in complex tissue samples in situ. Such technology will be instrumental in advancing fundamental studies in this area and be of particular relevance in understanding more about degenerative and diseased tissue states.
EPSRC Crime Project Login
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Current Research Grants and Contracts
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- At crime scene DNA characterisation
Principal investigator: Prof Stephen J Haswell
Co-investigators: Professor Gillian Greenway, J Greenman and C Dyer
Awarding body: EPSRC
Amount awarded: 721675
- Commercialisation of Lab-on-a-Chip technology for DNA profiling
Principal investigator: Prof Stephen J Haswell
Co-investigator: J Greenman
Awarding body: EPSRC
Amount awarded: 171,163
- Development of novel catalytic structures and thermal regimes for continuous flow reaction chemistry
Principal investigator: Prof Stephen J Haswell
Co-investigators: Prof Paul Fletcher and Prof Steve Kelly
Awarding body: EPSRC
Amount awarded: 337,093
- Novel technologies for in situ environmental monitoring: linking sensor development to improved pollutant transport models.
Principal investigator: Professor Gillian Greenway
Co-investigators: Prof Stephen J Haswell and imb
Awarding body: EPSRC
Amount awarded: 150,353
- Development of a prototype micro fluidic device for the study of cell function within a tissue environment
Principal investigator: Prof Stephen J Haswell
Co-investigators: ced, jg, ams and kw
Awarding body: BBSRC
Amount awarded: 596,908
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Conference Presentations
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- Plenary Lecture, Development of a Miniaturised Real World Sampling Interface, London January.
| - Plenary Lecture, Reaction Intensification in Prague, July
| - Plenary Lecture, Process miniaturisation a route to knowledge generation, Budapest, September
| - Plenary Lecture, Reaction Intensification and Monitoring in Micro Fluidic Based Devices Copenhagen, October
| - Invited Lecture, What can Micro Fluidics bring to Measurement Science, INTERCET meting Runcorn, January.
| - Invited Lecture, Microwave induced reaction intensification in micro reactor devices, RSC meeting Liverpool, March.
| - Invited Lecture, Introduction to Micro Analytical Systems RSC London, May
| - Invited Lecture, Manipulating Multiphase Systems in micro reactors, Gordon Conference, Oxford, August
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Other Public Output
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- Scientific and Technical Aspects of Developing Lab on a Chip Technology Masterfoods, May
| - Reaction Intensification in Micro Reactors Leeds University seminar, July.
| - Witness at all party parliamentary inquiry in to forensic science provision
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