The impact of NADPH oxidase inhibition alone or combined with exercise in skeletal muscle of Apolipoprotein E deficient mice

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About this project

This is a lab based PhD project studying the attenuation of disease progression in a murine model of atherosclerosis.

In atherosclerosis, cellular oxidative stress is associated with disease progression and poorer outcomes. Atherogenic (ApoE deficient) mice fed fatty diets show increased oxidative stress in peripheral skeletal muscles, resulting in mitochondrial deficiency, altered protein function and poor exercise tolerance. A main enzymatic source of the reactive oxygen species responsible for oxidative stress in several tissues, are NADPH oxidases (NOX). Both NOX inhibition and exercise may reverse oxidative stress and restore physiological functions. In this established murine model of atherosclerosis, we aim to:

  • unpick the metabolic pathway by which physiological stimuli (exercise regimes) attenuate oxidative cellular damage and compare the impact different intensity exercise regimes
  • test the hypothesis that NOX inhibition utilising novel, newly developed pharmacological agents (NOX inhibitors e.g. ebselen and analogues) alleviates oxidative stress in skeletal muscle.
  • investigate whether the effects of exercise and NOX inhibition are additive.

The studentship will be an excellent opportunity to undertake a novel project with timely interest for human health. The student will develop expertise in several laboratory based techniques including immunohistochemistry and PCR.

This project is suitable for a student with laboratory skills (e.g. has degree in the biomedical sciences).


Supervisor 1. Dr Antonios Matsakas, Biomedical Sciences,

Co-supervisor 1. Prof Ian Chetter, Academic Vascular Surgical Unit,

Co-Supervisor 2. Prof Lee Ingle, Department of Sport, Health and Exercise Science,

Next steps


Full-time UK/EU PhD Scholarships will include fees at the ‘home/EU' student rate and maintenance (£14,121 in 2016/17) for three years, depending on satisfactory progress.

Full-time International Fee PhD Studentships will include full fees at the International student rate for three years, dependent on satisfactory progress.

Entry requirements

This project is suitable for a student with laboratory skills (e.g. has degree in the biomedical sciences).

Successful applicants will be informed of the award as soon as possible and by 8th May 2017 at the latest.


Find out more about research at HYMS and in Biomedical Sciences.

How to apply

Applications should be made through the HYMS web site stating the project title and supervisor’s name.

Application deadline: 13 March 2017

Research options:

PhD: 4 years (full-time)

The Postgraduate Training Scheme

PhD students at the University of Hull follow modules for research and transferable skills development and gain a Masters level Certificate, or Diploma, in Research Training, in addition to their research degree.