Biochemistry-spare-Cropped-1919x606

PhD

Development of Clinical Radiochemistry Tools

About this project

The PET Healthcare technologies cluster aims to expand the scope of PET research at both the University and the Hull & East Yorkshire NHS Trust with the aim of improving patient outcomes using a ‘dose-on-demand’ approach for the provision of PET service to patients. The University is unique in that it houses a benchtop cyclotron dedicated to preclinical research in a bespoke PET facility, and links to a clinical dose-on-demand cyclotron development at Castle Hill Hospital – one of the first such facilities to be built worldwide. Studentships in the cluster build on local academic and clinical expertise and focus on specific areas of PET-themed research, including i)  lowering the cost of ‘dose-on-demand’ 18F-radio-pharmacy production via the application of microfluidic devices, ii) the improvement of 68Ga-PET methods to assess radiation dose from molecularly targeted radiotherapy using 177Lu, iii) the validation of translational methods to allow inhaled drug deposition to be quantified using PET, and iv) the application of machine learning tools to improve scatter correction and thus the quality of reconstructed PET images.

Development of Clinical Radiochemistry Tools for Dose-On-Demand PET

A key challenge in delivery of new molecular imaging agents (at an appropriate cost point with minimal impact on staff training and infrastructure) is the radiochemical synthesis method. In general, they are designed for large volumes and have major infrastructure requirements. The aim of this project is to further develop radiochemical synthesis methods and test automated protoypes in a clinical radiopharmacy at Castle Hill Hospital, in collaboration with the NHS radiopharmacy team, . The initial focus will be on fluorine-18 radiochemistry but there will be the potential to extend this to carbon-11 synthetic protocols using the GE GENtrace cyclotron on the Castle Hill Hospital site.

Supervisors

You are strongly advised to contact a potential supervisor and to discuss your research proposal, well before you submit an application. Please refer to the Faculty of Health Sciences research pages.

If you have any queries, please email Dr Chris Cawthorne.

Next steps

Funding

To celebrate the University's research successes, the University of Hull is offering a full-time UK/EU PhD Scholarship or International Fees Bursary.

Entry requirements

Applicants should have at least a 2.1 undergraduate degree in Chemistry or Biomedical engineering for Project 1, Pharmacological Sciences for Project 2, Pharmacological Sciences or Chemistry for Project 3, and Biomedical engineering/Computer Science for Project 4 together with relevant research experience. It is anticipated that the successful applicant will have a 1st class undergraduate degree or Masters level qualification. 

How to apply

Applications for scholarship consideration at the University of Hull should be made through the Postgraduate Application system.

On the second page of your application, please select “Graduate Scholarship” as the type of scholarship you are applying for. 

Applicants are strongly encouraged to first identify and contact a potential supervisor.

Apply now

Application deadline: Thursday 8th February

Fees

Full-time UK/EU PhD Scholarships will include fees at the ‘home/EU' student rate and maintenance (£14,553 in 2017/18) for three years, depending on satisfactory progress.

Full-time International Fee PhD Studentships will include full fees at the International student rate for three years, dependent on satisfactory progress.