Biochemistry-spare-Cropped-1919x606

PhD

Validation of PET-enabled Molecular Radiotherapy Dosimetry

About this project

The PET Healthcare technologies cluster aims to expand the scope of PET research at both the University and the Hull & East Yorkshire NHS Trust with the aim of improving patient outcomes using a ‘dose-on-demand’ approach for the provision of PET service to patients. The University is unique in that it houses a benchtop cyclotron dedicated to preclinical research in a bespoke PET facility, and links to a clinical dose-on-demand cyclotron development at Castle Hill Hospital – one of the first such facilities to be built worldwide. Studentships in the cluster build on local academic and clinical expertise and focus on specific areas of PET-themed research, including i)  lowering the cost of ‘dose-on-demand’ 18F-radio-pharmacy production via the application of microfluidic devices, ii) the improvement of 68Ga-PET methods to assess radiation dose from molecularly targeted radiotherapy using 177Lu, iii) the validation of translational methods to allow inhaled drug deposition to be quantified using PET, and iv) the application of machine learning tools to improve scatter correction and thus the quality of reconstructed PET images.

Validation of PET-enabled Molecular Radiotherapy Dosimetry. 

Whilst molecular imaging can provide diagnostic/prognostic information for cancer patients, it can also guide the application of therapeutic isotopes attached to the same probe (so-called ‘Theranostics’), i.e. PET imaging allows the stratification of patients for peptide receptor radionuclide therapy (PRRT). Although such therapy is by definition tumour-targeted, differences in the way the individual patients clear the drug from the body require dose optimisation to determine the ideal therapeutic dose. This project seeks to explore whether pharmacokinetic data derived from initial 68Ga scans can be used to predict both tumour and normal organ uptake and dosimetry, starting in relevant preclinical models and moving the nuclear medicine clinic at Castle Hill Hospital as patient therapy is developed, building on initial experience withradium-223 for prostate cancer metastasis.

Supervisors

You are strongly advised to contact a potential supervisor and to discuss your research proposal, well before you submit an application. Please refer to the Faculty of Health Sciences research pages.

If you have any queries, please email Dr Chris Cawthorne.

Next steps

Funding

To celebrate the University's research successes, the University of Hull is offering a full-time UK/EU PhD Scholarship or International Fees Bursary.

Entry requirements

Applicants should have at least a 2.1 undergraduate degree in Chemistry or Biomedical engineering for Project 1, Pharmacological Sciences for Project 2, Pharmacological Sciences or Chemistry for Project 3, and Biomedical engineering/Computer Science for Project 4 together with relevant research experience. It is anticipated that the successful applicant will have a 1st class undergraduate degree or Masters level qualification. 

How to apply

Applications for scholarship consideration at the University of Hull should be made through the Postgraduate Application system.

On the second page of your application, please select “Graduate Scholarship” as the type of scholarship you are applying for. 

Applicants are strongly encouraged to first identify and contact a potential supervisor.

Apply now

Application deadline: Thursday 8th February

Fees

Full-time UK/EU PhD Scholarships will include fees at the ‘home/EU' student rate and maintenance (£14,553 in 2017/18) for three years, depending on satisfactory progress.

Full-time International Fee PhD Studentships will include full fees at the International student rate for three years, dependent on satisfactory progress.