sandra jones

Dr Sandra Jones

Senior Lecturer in Biomedical Science

Faculty of Health Sciences

School of Life Sciences

s.a.jones@hull.ac.uk

+44 (0) 1482 466463

Sandra gained her BSc from the University of Leeds and her PhD from the University of Liverpool. She returned to Leeds for her first doctoral position, where her ongoing research into ageing and the heart began. This developed during her senior doctoral position, funded as principal investigator by the BHF, followed by a Lectureship in Physiology. Sandra was appointed to a Lectureship in Biomedical Science at Hull in 2007. She is also a member of the Centre for Cardiovascular and Metabolic Research at Hull York Medical School. Her research concerns the causes of cardiac dysfunction, particularly in association with ageing.

Research

Research Interests

  • Cardiac physiology and dysfunction
  • Ageing of the heart, with a focus on ion channels
  • Innovative tools for clinical cardiology
  • Endogenous stem cells in the heart and their newly derived myocytes
  • Interactions of exercise-training with cardiac ageing
  • Application of microfluidics in cardiology

Research groups

University of Hull (Professor John Greenman, microfluidics and lab-on-a-chip technology) 

University of Leeds (Dr Matthew Lancaster, exercise intervention on cardiac function and expert in electrophysiology)

University of Liverpool (Professor Anne McArdle, ageing and exercise studies) 

University of California, Davis (Dr Jose Puglisi, advisor of ‘LabHeart’ to enable basic modelling of functional data) 

University of Leeds (Dr Michael Colman, computational modelling expert) 

Castle Hill Hospital, Hull (Professor Mahmoud Loubani, clinical cardiologist, and Dr Jane Caldwell, clinical electrophysiologist)

Publications

Walton RD, Rostron KA, Jones SA, Kayani AC, Close GL, McArdle A and Lancaster MK 'Interactions of Short-Term and Chronic Treadmill Training with Ageing of the Left Ventricle of the Heart', The Journals of Gerontology: Biological Sciences Medical Sciences, 71(8):1005-13 (2016)

Jones SA and Lancaster MK, 'Progressive Age-Associated Activation of JNK Leads to Conduction Disruption in the Ageing Atrium', Mechanisms of Ageing Development, 146:72-80 (2015)

Kim S, Choisy S, Barman P, Zhang H, Hancox J, Jones SA and James A, 'Atrial Remodelling and the Substrate for Atrial Fibrillation', CirculationArrhythmia and Electrophysiology, 4:761-769 (2011)

Jones SA, Yamamoto M, Tellez JO, Billeter R, Boyett MR, Honjo H and Lancaster MK, 'Distinguishing Properties of Cells from the Myocardial Sleeves of the Pulmonary Veins; a Comparison of Normal and Abnormal Pacemakers, CirculationArrhythmia and Electrophysiology, 1:39-48 (2008)

Jones SA, Boyett MR and Lancaster MK, 'Declining into Failure: the Age-Dependent Loss of the L-Type Calcium Channel within the Sinoatrial Node, Circulation;115:1183-90 (2007)

Teaching

Programmes taught on

Modules list

  • Human Physiology
  • Biological Basis of Disease
  • Muscle Fitness and Failure
  • Reviews in Biomedical Science
  • 20-credit research project
  • 40-credit research project
  • Diseases in Biomedicine
  • Advanced Reviews in Biomedical Science

Research PhDs

Dr Jones welcomes applicants with experience in mammalian physiology (at degree level) and specific knowledge of the heart. Applicants should understand how ion channels contribute and give rise to the normal action potential of the mammalian heart at a basic degree level, as her research focuses on cardiac dysfunction and how it arises (for example with ageing). The techniques used in the laboratory are proteomic, genomic and functional. At the time of appointment, specific projects will be offered in line with ongoing projects in the group.

Completed PhDs

  • Amy Dawson, Paper Microfluidics for Clinical Diagnostics Using Colorimetric Detection Methods, 2010–14 (as second supervisor)
  • Dr Fiona Hatch, Age-Associated Changes to Calcium Handling Proteins across the Whole Heart, 2009–13 (as primary supervisor)
  • Amy Dawson, Age-Dependent Expression and Distribution of Cardiac Progenitor Cells in the Adult Heart, 2009–10 (Research MSc, as primary supervisor)

Current PhD supervisions

  • Stephanie Cooper, Microanalysis ‘On-Chip’ of Cardiac Function, 2013– (primary supervisor)
  • Donatus Onwuli, Sodium Channel Mutations, 2014– (co-supervisor)

Teaching awards and accolades

  • Postgraduate Certificate in Learning and Teaching in Higher Education, University of Leeds
  • Fellow of the Higher Education Academy

 

Professional highlights

Academic qualifications

  • BSc (Hons) Biochemistry with Molecular Biology, University of Leeds
  • PhD Pathophysiology, University of Liverpool
  • Postgraduate Certificate in Learning and Teaching in Higher Education, University of Leeds

External roles

  • Fellow of the Physiological Society
  • Fellow of the Higher Education Academy
  • Professional member of the American Heart Association
  • Member of the British Society for Research on Ageing
  • Member of the British Society for Cardiac Research

External roles

  • Abstract reviewer for the American Heart Association's Scientific Sessions
  • Representative of the Physiological Society at the University of Hull

Professional highlights

Conferences co-organised

  • British Society for Cardiovascular Research, Leeds, 2016
  • Physiological Society Inaugural H3 symposium, London, 2014
  • Northern Cardiac Research Group, Hull, 2011
  • British Society for Research on Ageing, Manchester, 2009

Invited speaker

  • University of Florida, Gainesville, 'Ageing to Arrhythmias: Conundrums of Connections in the Ageing Heart', 2015
  • Physiological Society Inaugural H3 Symposium, London, 'Stem Cells and the Heart: Where Do the Future Therapies Lie for Cardiac Regeneration?', 2014