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Professor Nicole Pamme

Professor in Analytical Chemistry/ Director of Research

Faculty of Science and Engineering

School of Mathematics and Physical Sciences

n.pamme@hull.ac.uk

01482 465027

Professor Nicole Pamme is the Director of Research in the School of Mathematics and Physical Sciences.

Her research interests evolve around the study of microfluidic lab-on-a-chip devices, which allow precise handling of liquids at microscopic scales.

Her group applies lab-on-a-chip technology for environmental analysis on-site, for clinical diagnostics at the point-of-care and the synthesis of smart materials.

Prof Pamme's group has developed a range of outreach activities to engage the general public. She is responsible for providing leadership and encouraging research culture within the school.

Research

Research Interests

  • Developing lab-on-a-chip for environmental analysis, pharmaceutical quality control, clinical diagnostics and synthesis of smart materials

  • Exploitation of magnetic attraction forces

  • Exploitation of magnetic repulsion forces

  • Photochemistry

  • Pre-concentration methods

  • Quality control for (radio)pharmaceuticals

  • Food pathogens

  • IFAST for pathogen analysis

  • Integrated DNA analysis

  • Tissue on-chip/organs-on-chip

  • Lab-on-a-chip outreach

Research groups

  • Lab-on-a-Chip Research Group

  • PET Research Centre

  • Analytical Sciences Research Theme (Chemistry)

  • Advanced Wound-Care (PhD cluster)

  • Sullied Sediments (EU Interreg North Sea Region)

Publications

Mark D Tarn, Dzmitry Maneuski, Richard Alexander, Nathaniel J Brown, Val O’Shea, Sally L Pimlott, Nicole Pamme, Stephen J Archibald, 'Positron Detection in Silica Monoliths for Miniaturised Quality Control of PET Radiotracers', Chemical Communications, 2016, 52, 7221-7224.

Olivia Mosley, Louise Melling, Mark D Tarn, Cordula Kemp, Mohammad M N Esfahani, Nicole Pamme, Kirsty J Shaw, 'Sample Introduction Interface for On-Chip Nucleic Acid-based Detection of Helicobacter Pylori from Stool Samples', Lab on a Chip, 2016, 16, 2108-2115.

Mohammad M N Esfahani, Mark D Tarn, Tahmina A Choudhury, Laura C Hewitt, Ashley J Mayo, Theodore A Rubin, Mathew R Waller, Martin G Christensen, Amy Dawson, Nicole Pamme, 'Lab-on-a-Chip Workshop Activities for Secondary School Students', Biomicrofluidics, 2016, 10, 011301.

Bingyuan Lu, Mark D Tarn, Nicole Pamme, Theoni K Georgiou, 'Tailoring pH-Responsive Acrylic Acid Microgels with Hydrophobic Crosslinks for Drug Release', Journal of Materials Chemistry B, 2015, 3, 4524 - 4529.

Damien Robert, Nicole Pamme, Hélène Conjeaud, Florence Gazeau, Alexander Iles, Claire Wilhelm, 'Cell Sorting by Endocytotic Capacity in a Microfluidic Magnetophoresis Device', Lab on a Chip, 2011, 11, 1902-1910.

Full list

Teaching

Programmes taught on

Modules list

  • Microanalytical Chemistry, level 7

  • Biosensors, level 7

  • Analytical laboratory courses (level 3, 4, 5, 6)

  • Molecular Spectroscopy, level 5

  • Radioanalytical Chemistry, level 5

  • Forensic DNA Analysis and Forensic Toxicology, level 4

  • Physical Chemistry for Foundation Chemistry, level 3

Research PhDs

Applications to the PhD programme are always welcome. Please contact me to discuss specific projects.

Completed PhDs 

Bingyuan Lu, Amphiphilic Microgel Synthesis for Drug Delivery (co-supervisor)

Ali-AlOrabi, On-chip Assembly of Drug and Reagent Delivery Vesicles (main supervisor)

Zahra Ghobaei-Namhil, Nanogap Bio-Sensors for DNA Analysis (co-supervisor)

Zeid Oiaidha, Development of a Portable Device for Monitoring Toxic Organic Compounds in the Environment (co-supervisor)

Hayley Bignell, Novel Diagnostic 64Cu and 68Ga PET Radiotracers: from Microfluidic Synthesis to Imaging (co-supervisor)

Kapiraj Chandrabalan, A Microfluidics Approach to Studying the Role of Oxidative Stress in Cellular Transformation and Disease Induction (co-supervisor)

Anupam Das, Bio-hydrogen Production by using Artificial Symbiotic Biofilms of Cyanobacteria (co-supervisor)

Mohammad Chowdhury, Engineering Design for Miniature Biochemical Analysis Systems (co-supervisor)

Chayakom Phurimsak, Clinical Diagnostics in Continuous Flow (main supervisor)

Rachel Smith, On-Chip Synthesis of Anti-Cancer Drugs (co-supervisor)

Emily Lumley, Development of a Microfluidic Device for the In Situ Production of Singlet Oxygen for Chemical and Biological Applications (co-supervisor)

Francesco de Leonardis, Microfluidic Modules for Pre-Concentration of [18F]Fluoride in Positron Emission Tomography (PET) Radiotracer Synthesis (main supervisor)

Martin Vojtisek, Magnetic Manipulation of Particles for Microfluidic Continuous Flow Processes (main supervisor)

Mark D Tarn, Continuous Flow Processes on Single Magnetic and Diamagnetic Particles in Microfluidic Devices (main supervisor)

Entesar Al Hetlani, Generation and Manipulation of Magnetic Droplets in Microfluidic Devices (co-supervisor)

Sally A Peyman, Bioanalysis on Single Magnetic Particles (main supervisor)

Current PhD supervisions 

Samantha Richardson, Dip Stick-based Analysis for Environmental Pollution Monitoring (co-supervisor)

Asif Muhammad, Microfluidic Paper-based Assays for Veterinary Diseases (main supervisor),

Polly Sanders, Microfluidics and 3D Printing of Functional Composites (co-supervisor)

Lydia Baldwin, Interrogating Interplay between Gut and Brain in a Lab-on-a-Chip Platform (co-supervisor)

Thomas Collins, Spheroids on-Chip (co-supervisor)

Beverly Andrews, Label-free Optical Biosensors for Real-Time Cell Imaging (main supervisor)

Martin Gedsted Christensen, Personalised Medicine: a Lab-on-a-Chip Platform for the Maintenance and Real-Time Analysis of Patient Tissues (main supervisor)

Addison Marshall, Plasmonic Nano-Sensors with Ultra-High Detecting and Identifying Molecules Capabilities (co-supervisor)

Teaching awards and accolades

PostGraduate Certficate in Higher Education (PGCHE)

Fellow of the Higher Education Academy (FHEA)

Professional highlights

Academic qualifications

  • Diploma in Chemistry, University of Marburg

  • PhD, Single Particle Analysis in Microfluidic Chips, at Imperial College London

  • Independent Research Fellowship in the International Centre of Young Scientists (ICYS) at the National Institute for Materials (NIMS) Sciences in Tsukuba (Japan)

External roles

Member of the board of directors of the Chemical and Biological Microsystems Society

On the editorial advisory board of Lab on a Chip, RSC Publishing

Collaborations include

  • pathogen analysis in food with bioMerieux (France)

  • pathogen analysis in drinking water with CSIR in South Africa supported through the Newton Fund

  • quality control of radiopharmaceutical with LabLogic, the Universities of York and Sheffield

  • Sullied Sediments (EU-Interreg project) studying watch list chemicals in river sediments with partners in the UK, Germany, Belgium and the Netherlands

  • ViBrANT (EU-ITN), research into pathogen infections with partners across Europe

Awards and accolades

  • Fellow of the Royal Society of Chemistry (FRSC)

  • Fellow of the Higher Education Academy (FHEA)

Professional highlights

Worked in Tsukuba, Japan, as an independent research fellow in the International Centre for Young Scientists (ICYS) at the National Institute for Materials Science NIMS.