Dr Huw Jones

Lecturer in Biochemistry

Faculty of Science and Engineering

School of Mathematics and Physical Sciences

huw.jones@hull.ac.uk

01482 463320

Dr Jones is a lecturer in biochemistry, with research interests in the modulation of health and disease states by natural products.

He is particularly interested in how chemicals found within the diet can act as medicinal drugs, particularly in terms of modulating redox signaling and oxidative stress.

This research uses a variety of cell culture models, in addition to collaborations with clinicians and physiologists, to undertake research at the tissue and human levels.

Dr Jones contributes to the delivery and teaching of BSc / MBiochem Biochemistry, and delivers lectures on biochemistry as part of the MSc in Clinical Exercise Physiology.

Research

Research Interests

  • The modulation of reactive oxygen and nitrogen species production by dietary micronutrients (e.g. polyphenols, co-enzyme Q10) in models of health and disease with a focus upon vascular dysfunction and aged skeletal muscle

  • Measurement of reactive oxygen and nitrogen species in biological samples and systems

  • Synthesis of circulating metabolites of natural products for the application to mechanistic studies

Research groups

  • Hull York Medical School, University of Hull (Prof Thozhukat Sathyapalan)

  • School of Mathematics and Physical Sciences, University of Hull (Prof Nicole Pamme, Dr Kevin Welham)

  • School of Life Sciences, University of Hull (Dr Mark Fogarty, Dr Grant Abt, Prof Sean Carroll, Dr Andrew Garrett, Dr James Hobkirk, and Dr Frank Voncken)

  • Sport and Exercise Sciences, Ulster University (Prof Gareth Davison)

Publications

O’Doherty AF; Jones HS; Sathyapalan T, Ingle L; Carroll S. 'The effects of acute interval exercise and strawberry intake on postprandial lipaemia', Medicine and Science in Sports Science, vol 49, 11, pp 2315-2323 (2017)

Jones HS; Gordon A; Magwenzi S; Naseem K; Atkin SL; Courts FL. 'The dietary flavonoid quercetin ameliorates angiotensin II-induced redox signalling imbalance in a human umbilical vein endothelilal cell model of endothelial dysfunction via ablation of p47phox expression', Molecular Nutrition and Food Research, 60 (4), pp 787-797 (2016)

Magawenzi S; Woodward C; Wraith KS; Abrurima A; Raslan Z; Jones HS; McNeil C; Wheatcroft S; Yuldasheva N; Febbriao M; Kearney M; Naseem K. 'Oxidised LDL activates blood platelets through CD36-NADPH oxidase-mediated inhibition of the cGMP/Protein kinase G signalling cascade', Blood, 125 (17), pp 2693-703 (2015)

Full list

Teaching

Programmes taught on

Modules list

Year 1

  • Insights into biochemistry (biochemistry)

  • Introduction to DNA and chromatography

Year 2
  • Biochemistry and professional skills 1 (biochemistry)

  • Biochemistry and professional skills 2 (biochemistry)

  • Forensic science in practice

Year 3
  • Biochemistry group project (biochemistry)

  • Advanced topics in biochemistry (biochemistry)

  • Reviews in biochemistry (biochemistry)

Year 4
  • Biochemistry of health and disease

Research PhDs

Dr Jones welcomes applications in

  • pharmacological effects of natural products in health and disease states

  • analytical approaches to the measurement of reactive oxygen species and oxidative stress markers

  • novel methods for the synthesis of human circulating metabolites of xenobiotics and natural products     

Completed PhDs

  • Eleanna Chalari (as co-supervisor), The effects of intermittency and acceleration on exercise-induced oxidative stress after high-intensity intermittent exercise (2017)

Current PhD supervisions 

  • Nikki Simpson, Effect of coenzyme Q10 supplementation upon skeletal muscle oxidative signaling in vitro and in vivo (as co-supervisor)

  • Rachel Burke, Nitrate supplementation and vascular function (as co-supervisor)

Professional highlights

Academic qualifications

  • PhD, University of Birmingham, 2006-2010        

  • MRes Molecular Mechanistic Toxicology, University of Birmingham, 2005-2006     

  • BSc (Hons) Medical Biochemistry, University of Birmingham, 2002-2005